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Administrative Core
SUMMARY, ADMINISTRATION CORE CORE A, CORE LEAD: ALAN TALL Cardiovascular disease, including atherosclerosis, is a major cause of morbidity and mortality in the United States and ar...
Bioinformatics and Biostatistics
Cardiovascular diseases, including atherosclerosis, are a major cause of death globally. Lipid-lowering therapies and interventions lower the risk of major adverse clinical events...
Mouse and Human Atherosclerotic Tissue
Project Summary/Abstract As the Mouse and Human Atherosclerosis Tissue Core, Core C will provide a high level of harmonized service for murine and human atherosclerotic lesion anal...
Inflammatory crosstalk between macrophages and stromal cells in clonal hematopoiesis
Clonal hematopoiesis (CH) arises from somatic mutations such as in JAK2 or TET2 that provide a fitness advantage to hematopoietic stem cells and outgrowth of clones of blood cells....
Macrophage Metabolic Pathways and Cellular Crosstalk in Atherosclerosis Regression
In human atherosclerosis, a positive-feedback cycle in lesional macrophages (Ms) involving efferocytosis (clearance of apoptotic cells [ACs]) and inflammation resolution is impair...
Harnessing molecular breaks on macrophage efferocytosis in atherosclerosis
Lipid-lowering approaches reduce atherosclerotic cardiovascular disease (ACVD), but significant residual risk remains. Macrophage (Mφ) accumulation and defective phagocytic clearan...
Elucidating mechanisms that differentiate between uptake of toxic heavy metals and beneficial micronutrients in food crops
PROJECT SUMMARY Cadmium (Cd) is an important contaminant that threatens human health, as well as agricultural productivity and biodiversity. In the United States, the largest sourc...
Roles of Placental Mitochondria in the Vicious Cycle of Diabetes and Pregnancy
PROPOSAL ABSTRACT Type II diabetes mellitus (T2D) with increasing prevalence represents a major burden for health and care system and individuals. However, the root cause of T2D ha...
Transcription Factor Discovery in the Opportunistic Pathogen Pseudomonas aeruginosa
Project Summary Pseudomonas aeruginosa is a gram-negative, aerobic/facultatively anaerobic, rod-shaped bacterium that is commonly found in freshwater environments. However, P. aeru...
Determining the molecular basis for extreme virus stability, a structure-guided approach
PROJECT SUMMARY In the long-term we aim to understand the genetic, biochemical and structural basis for extreme virus function and stability. Sulfolobus Spindle-shaped Virus 1 (SSV...
De Novo Synthesis of Collagen-Like Polymers for Biomedical Applications
Project Summary Collagen has been used for biomedical applications for many decades due to its unsurpassed biocompatibility and chemically tunable mechanical properties. There is a...
Brain Vascular Signatures in Drug-induced Recurrent Hypoglycemia and Associated Cognitive Dysfunction
ABSTRACT Type 2 diabetes mellitus (T2DM) poses a serious global health issue, affecting millions globally, with a concerning rise in younger age groups. T2DM patients often suffer...
The Impact of Nf1 Mutation on Oligodendrocyte Development and Fine Motor Learning
PROJECT SUMMARY/ABSTRACT Neurofibromatosis type 1 (NF1) is a common genetic disease caused by mutations in the gene NF1. Most NF1 pediatric patients present with diverse neurologic...
Substance Use and Perceived Discrimination Based on Socioeconomic Status Among Adolescents
Adolescents low in socioeconomic status (SES) are nearly twice as likely to smoke cigarettes or vape and are more likely to use alcohol, cannabis, and illicit drugs than high-SES a...
Decoding the cellular and molecular mechanisms of epileptogenesis and disease progression in mTORopathies
ABSTRACT mTORopathies, such as focal cortical dysplasia type II (FCDII), is the most common underlying pathology in children with drug-resistant epilepsies. However, the underlying...
Developing robust anti-Obesity Medication ImplemeNtatiOn approaches to maximize population health (the DOMINO study)
NOTE: You must submit in Word format, not PDF, for eRA to update all the systems.The 2021 Food and Drug Administration (FDA) approval of the glucagon-like peptide 1 (GLP-1) recepto...
Mechanism of the Human Telomere C-Strand Fill-In Machinery Assembly and Activation at Chromosome Ends
Project Summary/Abstract Telomeres are specialized nucleoprotein structures that protect chromosome ends and confer genome stability in eukaryotic cells. Without telomeres, chromos...
Defining KSHV LANA functions in viral pathogenesis and immune evasion
PROJECT SUMMARY Gammaherpesviruses (GHVs) are DNA tumor viruses that establish lifelong, chronic infections of host lymphocytes. The expression of viral gene products that manipula...
Chemical tools for modulating the fetal hemoglobin inducer BCL11A
Project Summary/Abstract Proximity-based protein modulators such as proteolysis targeting chimeras (PROTACs) and molecular glues represent a new therapeutic modality because they c...
Improved detection of coronary artery disease in atrial fibrillation patients using ungated perfusion MRI methods
Summary Coronary artery disease (CAD) is a major healthcare problem that affects over 20 million Americans and costs an estimated $82.8 billion each year. Atrial Fibrillation (AFIB...