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99,167 grants found
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Characteristics and Determinants of Post-COVID Neurocognitive Dysfunction
Neurologic symptoms are among the most common post-acute sequelae of COVID-19 (PASC). Recent studies show that there is a very high rate of neurocognitive changes among Veterans su...
Oncostatin M Receptor in Pancreatic Adenocarcinoma
Pancreatic ductal adenocarcinoma, the most common form of pancreatic cancer, carries a 5-year mortality rate of 89%. Incidence and mortality from PDAC is rising, such that PDAC wil...
A validated mouse model of brown fat targeting
Abstract/Project Summary Mice and human physiology are deeply affected by brown fat through its control of metabolic homeostasis and production of signaling molecules. As such, bro...
Capturing and characterizing the variability in physical therapy dose after orthopedic multi-level surgery in ambulatory children with Cerebral Palsy
Project Summary Ambulatory children with cerebral palsy (CP) can have profound impairments of the lower extremities including physical deformities, loss of motor function, and resu...
A Novel Vaccine Adjuvant KOR-selective Small Molecule Agonist
A Novel Vaccine Adjuvant KOR-selective Small Molecule Agonist ABSTRACT Discovering safe and effective adjuvants that are crucial for vaccine efficacy is a key challenge. The skin i...
Disruption of the Cardiac-Coronary Axis as a Mechanism of HFpEF
Heart failure is the leading cause of mortality, and about 6.2 million adults in the United States have heart failure. Heart failure with preserved ejection fraction (HFpEF) has ty...
Regulatory mechanisms of hematopoietic stem cell functions post-transplant
Abstract Hematopoietic stem cells (HSC) sustain the production of all blood and immune cells throughout life by differentiating into all blood lineages and regenerate long-lived HS...
Molecular mechanism of the visual disorders caused by G90D and G90V rhodopsin mutations
PROJECT SUMMARY/ABSTRACT Vision begins in photoreceptor cells with light activation of the visual pigment, rhodopsin, which triggers a transduction cascade to produce the cellular...
Secondary distribution of HIV self-testing by FSW, pre-exposure prophylaxis (PrEP) starter packs and brief counseling to promote PrEP initiation and persistence among high-risk men in Uganda
PROJECT SUMMARY/ABSTRACT Current estimates project that roughly one in six new HIV infections in East and Southern Africa, where the majority of all incident HIV infections occur,...
Mechanosensitive Ion Channels Modulation by Membrane Composition
Project Summary Our current research focuses on investigating the mechanisms by which fatty acids (the building blocks of the plasma membrane) modulate the function of mechanosensi...
Expanding Translational Science in Arkansas
PROJECT SUMMARY Arkansas is a small and rural state with significant health disparities. The Translational Research Institute (TRI) at the University of Arkansas for Medical Scienc...
SUMOylation regulation of ribosome biogenesis
Project Summary Ribosome biogenesis, a complex and coordinated cellular process for making the ribosome in the nucleolus, is essential for cell growth and proliferation. Defects in...
CTSA UM1 Program at Wake Forest
PROJECT SUMMARY/ABSTRACT The emergence of large integrated health systems linked by common informatics platforms offers an unprecedented opportunity to study the impact of new ther...
Stanford Center for Clinical and Translational Research and Education
ABSTRACT The mission of the Stanford CTSA is to transform clinical, translational, and science of translation research and education (CTSRE) at Stanford and across the CTSA consort...
New Methods for Nitrogen and Oxygen Heterocycle Synthesis
Project Summary/Abstract The efficient production of small organic molecules and chemical processes impacts pharmaceutical research, both drug discovery and process chemistry. Chir...
Mechanisms of vesicle trafficking and kinesin regulation
PROJECT SUMMARY Nearly every aspect of cellular function—from development to metabolism and signaling—requires that membrane proteins be targeted to the correct location in the cel...
Structure and Dynamics of Telomeres and Telomerase
Project Summary Telomeres are essential structures located at the ends of linear chromosomes that protect genomic integrity by preventing chromosomal fusion, degradation, and activ...
Actin Cytoskeleton Network Self-Organization
PROJECT ABSTRACT Cells assemble functionally diverse actin cytoskeleton networks with distinct architectures and dynamics to drive fundamental processes such as polarization, motil...
Genome-wide assessment of transcriptional state history
PROJECT SUMMARY The accurate description of cellular states—be it on the genomic, transcriptomic, or proteomic level—has been a major driver in the disentanglement of nature’s myst...
Cellular and Molecular Mechanisms of Atherosclerosis
Atherosclerotic cardiovascular disease (CVD) remains the leading cause of death worldwide and substantial residual CVD risk persists despite effective LDL-cholesterol (LDL-C) lower...