Browse All Grants
99,167 grants found
Showing 5,081 – 5,100 of 99,167 grants
Cystic Fibrosis Gene Therapy with adeno-associated viral vectors
Abstract: We and others have shown that AAV vectors have great potential as gene therapeutic agents (3-5), in particular for CF. Studies originating from our group led to the first...
Establishing novel therapeutic strategies to target RA pannus formation
Rheumatoid arthritis (RA) is the most common autoimmune disease which affects 2.5 million people in the US, many of which are VA military personnel. One in four veterans has arthri...
UNDERSTANDING OF ESSENTIAL GENE FUNCTION IN AGING
PROJECT SUMMARY Functional genomic studies have contributed enormously to our understanding of conserved genetic pathways influencing aging in evolutionarily divergent organisms. T...
C. albicans-intrinsic mechanisms defining gut colonization
Project Summary: The fungus Candida albicans is a frequent commensal of the gastrointestinal (GI) tract but is also an important cause of both mucosal and systemic disease. The GI...
Elucidating the Role of Tryptophan Hydroxylase 1 in Neuroendocrine Prostate Cancer
Project Summary/Abstract: Neuroendocrine prostate cancer (NEPC) is a fatal prostate cancer (PC) subtype with aggressive clinical features and a poor prognosis. Although it rarely o...
Integrated Proteomic and Metabolomic Determinants of Left Atrial Dysfunction
PROJECT SUMMARY Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are prevalent cardiovascular syndromes of aging that frequently co-exist. Unfort...
Molecular Imaging Guidance for Potentiating Chemoimmunotherapy in Pancreatic Cancer using Photodynamic Priming
ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is the 3rd most deadly cancers with a 5-year survival rate of only 3% in patients with metastases. Current efforts to improve outcom...
Adhesome signaling in lung injury and repair
PROJECT SUMMARY Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal fibrotic lung disease. IPF is characterized by fibroblast and myofibroblast foci and excessive accumu...
Disparities in Financial and Clinical Outcomes among Commercially-Insured Cancer Patients following the Affordable Care Act
Project Summary/Abstract Demographic changes in the commercially insured population following implementation of the Affordable Care Act (ACA)—specifically improved enrollment of th...
Double-stranded RNA in neuronal cell death in Alzheimer's and related neurodegenerative diseases
Project Summary Alzheimer's disease (AD) and related neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are characterized...
Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?
Adverse childhood experiences (ACEs), parenting, and social determinants of health (SDH) contribute to early life adversity (ELA), which can disrupt development in the brain, cardi...
The role of diet and aging in photoreceptor homeostasis and visual function decline
PROJECT SUMMARY/ABSTRACT More than half of the elderly population suffer from age-related eye disorders that compromise their ability to perform daily activities. Aging is a signif...
Exploring super charged NK cells as a novel cell-based immune therapy in targeting platinum resistant ovarian cancers
Women diagnosed with high grade serous ovarian cancers (HGSOCs) often suffer from disease relapse that is resistant to platinum-based chemotherapy. Effective treatments are needed...
Mechanism of the adrenal stress response protection against therapy-induced lethal immune activation
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for hematologic malignancies and other diseases, in which the donor's stem cells are...
Thrombopoietin Mimetic Peptides for Treatment of Fractures
SUMMARY Veterans with fractures suffer from injury-associated pain as well as post-operative surgical pain. The occurrence of a fracture contributes to acute pain and is largely ma...
Role of Factor Acetylation in the Regulation of HIV Transcription
PROJECT SUMMARY (See instructions): Fully exploiting the promise of factor acetylation as a relevant drug target in HIV infection has the potential to significantly advance progres...
1/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) – CCC
PROJECT SUMMARY Significance: Prematurity a major health problem in the United States, with more than 385,000 babies born preterm annually. The economic cost is more than $50 billi...
Neuroinflammation disrupts cardio-respiratory circuits and patterns
Inflammation of the central nervous system (CNS) develops in both sepsis (systemic infection) as well as sterile lung injury. The neuro-inflammation mirrors the peripheral inflamma...
Artificial Intelligence Imaging Predictors for Rectal Cancer Management
ABSTRACT: Colorectal cancers are the third most frequently occurring cancer in the military, occurring in up to 8% of Veterans. Veteran rectal cancer patients are often diagnosed e...
CARD9 in Ankylosing Spondylitis
Arthritis is a major health concern to the Veteran population who have 35% incidence rates. Ankylosing spondylitis (AS), a type of inflammatory arthritis that results in chronic ba...