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99,167 grants found
Showing 5,061 – 5,080 of 99,167 grants
Imaging Feedback for Histotripsy Renal Tumor Ablation
PROJECT SUMMARY: Renal cell carcinoma (RCC) is the sixth most common cancer in the United States, with ~ 82k new diagnoses estimated for 2023. Surgery is the preferred option for i...
Non-canonical Mechanisms and Unconventional Approaches to Activate AMPK and Glucose Uptake in the Skeletal Muscle of Older Rats
AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine kinase with many important effects, including putative anti-aging actions. AMPK plays a key role in the c...
Innate Immune Regulation of Powassan Virus Neurovirulence
Powassan virus (POWV) is a neurovirulent tick-borne flavivirus (FV) emerging in the N.E. US. POWV is present in tick saliva, injected into the skin during a 15-minute tick bite and...
Nitroimidazole susceptibility and mechanisms of resistance in Mycoplasma genitalium
PROJECT SUMMARY Mycoplasma genitalium is a sexually transmitted bacterial pathogen that frequently causes genital tract syndromes including urethritis in men and cervicitis, pelvic...
Age related loss of immune resilience during response to severe respiratory viral infections
Abstract. The clinical responses to respiratory viruses are very heterogenous as recently demonstrated by the COVID-19 pandemic with most aggressive clinical courses among elders,...
A murine model of Lyme neuroborreliosis
PROJECT SUMMARY Lyme disease (LD), the most prevalent tick-borne illness in the US (~300,000-475,000 annual cases), is caused by spirochetes of Borreliella burgdorferi (Bb) sensu l...
Predicting point-of-care outcomes for text message crisis interventions in teens
Project Summary/Abstract Over the last decade, suicidal ideation and suicide death have increased significantly across all age groups, but have shown the most dramatic rise in teen...
RNA-mediated endotheliopathy in diabetic vasculopathy
Project Summary More than 10% of the global adult population currently lives with diabetes mellitus (DM) and are experiencing or at higher risk for various diabetic vasculopathies...
Panretinal Circular Ranging OCT for Retinoblastoma
PROJECT SUMMARY Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. Although retinoblastoma is an aggressive cancer, early diagnosis and treatment m...
Next-Generation MEG Imaging for Quantifying Cortical-Subcortical Dynamics in the Context of HIV and Cannabis Use
Project Summary/Abstract Persons with HIV (PWH) living in the western world have a life expectancy near that of the general population, but remain at a significantly elevated risk...
Evaluating a novel policy to increase access to nicotine replacement therapy in community retailers
ABSTRACT There is a strong rationale to prioritize tobacco control policy interventions in communities at high risk for tobacco product exposure, lower access to pharmacies, and as...
Advancing MRI with an open inhomogeneous B0 magnet
Project Summary/Abstract The aim of this proposal is to enhance the technical development of an open MRI system that can be integrated into an exam table in a doctor's office,...
Exploring the epigenetic control of pancreatic cancer subtypes
PROJECT SUMMARY (from parent grant) Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer-related mortality in the United States. Unfortunately, both genomic and tran...
Text and Talk: A multi-level intervention to increase provider HPV vaccine recommendation effectiveness
PROJECT SUMMARY Understanding the factors related to for whom and why evidence-based human papillomavirus (HPV) vaccine implementation strategies are effective and sustainable will...
Elucidating underlying mechanisms in RIPK2-mediated toxicity following exposure to radiation
Radiation exposure can have detrimental effects to human health. Exposure to high doses of radiation can provoke acute radiation syndrome within days and often results in death of...
TweenVax: A comprehensive practice-, provider-, and parent/patient-level intervention to improve adolescent HPV vaccination.
PROJECT SUMMARY/ABSTRACT Persistent human papillomavirus (HPV) infection is responsible for over 30,000 new cases of cancer annually in the United States (US). HPV infection can be...
Determining the efficacy of psychedelic agents reversing depression-relevant amotivated behaviors with concomittant EEG biomarkers.
Project Summary Major depressive disorder (MDD) is a common and burdensome psychiatric disorder. Unfortunately, current depression treatments suffer from numerous weaknesses, inclu...
Addressing racial disparities in opioid overdose deaths using an open source peer recovery coach training and multimodal mobile health platform
PROJECT SUMMARY Black and Latinx people who use opioids (PWUO) bear a disproportionate burden of opioid-related overdose deaths. Racial disparities among PWUO are exacerbated by pe...
A novel, glutathione-dependent metabolic pathway drives metastatic outgrowth in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer-related death in the US, for which treatment remains basically unchanged in the past three decades. Although pat...
Intraretinal stimulation for high acuity artificial vision
Prosthetic electrical stimulation of inner retinal neurons can restore a sense of vision in patients with outer retinal degeneration, but implant patients to date report artificial...