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99,167 grants found
Showing 5,041 – 5,060 of 99,167 grants
Mechanisms of DNA methylation signaling and dysregulation in colon cancer
PROJECT SUMMARY Colon cancer is a leading cause of cancer-related death for both men and women in the United States. Abnormal DNA methylation patterning is an epigenetic hallmark o...
Alpha defensins: innate keepers of host-commensal homeostasis
Multiple innate immune mechanisms regulate commensal microbes and promote responses to pathogens. Identification of non-redundant functions of such mechanisms is not a simple task,...
A large-scale quasi-experimental evaluation of added sugar warning labels in restaurants
PROJECT SUMMARY In November 2023, New York City (NYC), NY became the first jurisdiction in the US to adopt an added sugar warning policy, which requires restaurants to display a wa...
Using ecological momentary data to inform a web-intervention for romantic partners concerned about their loved ones drinking
PROJECT SUMMARY Alcohol misuse negatively affects relationships and is significantly correlated with higher rates of relationship conflict, distress, and dissolution as well as oth...
Bach1 as a molecular target in sepsis
ABSTRACT In the US, 1.5 million people are affected by sepsis with a mortality of more than 250,000 annually. Each year over 35,000 Veterans are hospitalized with sepsis, and high...
Targeting the Warburg Effect in Kidney Cancer
Over 79,000 people will develop kidney cancer, also known as renal cell carcinoma (RCC), and almost 14,000 patients will die from this disease in the US this year. Risk factors suc...
Regulation of SWI/SNF chromatin remodeler composition and function.
PROJECT SUMMARY The evolutionarily conserved SWI/SNF chromatin remodeler, exists as distinct polymorphic complexes, BAF, PBAF and ncBAF, each with differing subunit composition. Th...
Vulnerability and Persistence of Neuroinflammation and Behavioral Deficits from Developmental Cannabinoid Exposure
ABSTRACT This proposal will address the critical need to define for cannabinoid exposure: 1) the most sensitive developmental exposure windows; 2) the dose- and sex-dependence of a...
Surveillance of Modifiable Social Determinants of Health for Prioritizing Wraparound Supports
Surveillance of Modifiable Social Determinants of Health for Prioritizing Wraparound Supports 60% of Veterans in Veterans Treatment Courts (VTCs) have a co-occurring mental health...
mHealth-CArdiac REhabilitation for INOCA (INOCA-CARE)
PROJECT SUMMARY. Patients with ischemia with no obstructive coronary artery disease (INOCA) experience debilitating symptoms that include angina, dyspnea, and fatigue. Management o...
Obesity-mediated protection in sepsis
ABSTRACT Sepsis is a major burden to the healthcare system being the most common cause for admission to the intensive care unit and the most expensive condition treated in US hospi...
Formation, metabolism and cell signaling actions of tryptophan catabolism-derived electrophiles
Under steady-state conditions, >90% of tryptophan (Trp) catabolism occurs in the liver via the kynurenine (Kyn) pathway. However, this process has important pathophysiological r...
Defining and Avoiding Molecular Mechanisms of Drug Resistance
Project Summary Defining and Avoiding Molecular Mechanisms of Drug Resistance Drug resistance is a major challenge in modern medicine. Resistance impacts the lives of millions, lim...
New organosulfur-based strategies for efficient construction of carbon-carbon and carbon-heteroatom bonds
Organosulfur compounds have had a profound effect on the improvement of human health and well-being. They comprise a quarter of the most prescribed small molecule drugs, with sulfu...
Machine learning to personalize antidepressant treatment
Half of people starting antidepressant medication experience no significant improvement with the first medication prescribed, leading either to discouragement and dropout or months...
A molecular pathway that links N-glycosylation to birth defects
Project Summary A molecular pathway that links N-glycosylation to birth defects Developmental defects are the leading cause of both fetal loss before birth and infant deaths after...
Stomal Senescence Regulator of Tumor Immunity and Progression
Project Summary The 5-year survival rate for patients diagnosed with pancreatic ductal adenocarcinomas (PDACs) is 11%. This poor outcome is due to multiple factors, including rapid...
Maturation, Germination, and Pathogenesis of Cryptococcus Spores
PROJECT SUMMARY/ABSTRACT Worldwide, over a billion people each year experience high morbidity and/or mortality from the effects of human fungal pathogens. People with AIDS, chemoth...
Central mechanisms of glucocorticoid circadian rhythm dysfunction in breast cancer
Project Summary Breast cancer is still the most common malignancy in women worldwide. Despite the incredible advances made in the past decades towards eliminating breast cancer, ne...
Deimplementation of Inappropriate Feeding Practices in Early Care and Education Settings
Project Summary More than 12 million children in the U.S. consume up to two-thirds of their dietary intake in early care and education (ECE) settings.1,2 Yet, educators in ECE ofte...