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99,167 grants found
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Synthetic lethal targeting of KRAS/KEAP1 co-mutant non-small cell lung cancer
Abstract Activating KRAS mutations occur in 20-40% of non-small cell lung cancers (NSCLCs). About 20% of the KRAS mutation tumors have co-occurring mutations of KEAP1 that are resi...
Point-of-care Nucleic Acid Amplification Test for pangenomic Hepatitis C diagnosis in outpatient clinics
ABSTRACT Hepatitis C virus (HCV) infection is a widely prevalent bloodborne infection, with approximately 71 million global (2.4 million in USA) chronic infections worldwide. HCV i...
Defining West Nile virus infection of the lymphatics using single cell techniques
ABSTRACT Mosquito- and tick-borne neurotropic arboviruses cause annual epidemics of virus-induced encephalitis throughout the world and are considered some of the most rapidly spre...
p16INK4a+ fibroblasts regulate epithelial regeneration after injury in lung alveoli through the SASP
PROJECT SUMMARY ABSTRACT Cellular Senescence is as an acquired state cells enter in response to environmental stressors or tumor evasion. Senescent cells cease their proliferative...
Decoding glioma evolution and progression by multi-dimensional single-cell profiling
PROJECT SUMMARY / ABSTRACT Research Plan: Tumor evolution is a fundamental obstacle to cancer treatment, as malignant cells adapt to treatment and change during progression. Unders...
Neurodevelopmental effects of flame retardant exposure
Project Summary Rates of neurodevelopmental disorders (NDDs) with socioemotional deficits are rapidly rising, including general and social anxiety disorders (ADs, more common in wo...
Use of alpha-frequency deep transcranial interference stimulation (tIS) to understand and modify temporal dynamics of face emotion recognition and social/affective function.
A critical aspect of social cognition is the ability to infer emotion based upon facial expression, termed face emotion recognition (FER). We have recently shown that FER deficits...
IL-17-epithelial cells interaction in organ damaging infections
ABSTRACT The di-morphic commensal fungus Candida albicans causes severe bloodstream infection known as disseminated candidiasis (candidiasis). Candidiasis is the 3rd most common no...
Closed-Loop Deep Brain Stimulation for Controlling Abnormal Neural Synchronization and Oscillations
Project Summary/Abstract Neurophysiological and mental ailments such as epilepsy, Parkinson’s disease (PD), schizophrenia, and Alzheimer’s disease affect millions of lives and cost...
Testing an mHealth Digital Dashboard to improve Quality of Delivery of Evidence-based Interventions that Promote Family Mental Health and Functioning in Rwanda.A Hybrid Type 3 Study.
PROJECT SUMMARY Globally, mental disorders are the second largest contributor to the burden of disease in adults. In settings disrupted by war and civil unrest, violence and loss c...
14-3-3-zeta regulation of islet health
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Pancreatic islet dysfunction is central to type...
Adapting flow cytometry methods for early detection of acute hematologic malignancies in Kenya including the improvement of sample flow processes and technical training of personnel
The ability to diagnose and classify leukemias and lymphomas (LLs), in children and young adults is limited in Kenya and most of Sub-Saharan Africa. LLs represent nearly half the c...
Profiling malarial lipid biosynthesis and key acyl-coenzyme A synthetase activities with fatty acid alkynes
ABSTRACT Malaria is a major public health burden, causing over a half million deaths and two hundred million clinical episodes annually. During the pathogenic, asexual erythrocytic...
Mechanisms of CD4 autoreactivity after checkpoint inhibition
ABSTRACT The use of checkpoint inhibitors has altered the treatment landscape in oncology, leading to cures in previously untreatable diseases. Checkpoint inhibitors block the func...
The Maui Wildfire Exposure Cohort Study on Community Health and Resilience
PROJECT SUMMARY/ABSTRACT In August 2023, the unprecedented Maui wildfires, Hawaii's worst natural disaster, aggravated existing socioeconomic and health disparities among Maui...
3D bioengineered microfluidic platform for research on Ewing sarcoma bone metastasis
Ewing sarcoma (ES) is a pediatric malignancy, which carries adverse prognosis in its metastatic form. Bone metastases, although less common, associate with the worst clinical outco...
Tumor and Host Immune signatures associated with health disparities in outcomes following GD2 immunotherapy in neuroblastoma
PROJECT SUMMARY Neuroblastoma (NB) is the most common extracranial solid tumor of childhood that leads to a disproportionate number of childhood cancer deaths and an even more disp...
Targeting the ROR2/p-GSK3bS9 pathway to suppress metastasis in SMARCA4-deficient lung adenocarcinoma
Metastatic lung cancer kills >160,000 people in the US annually, and 10%-50% of patients with surgically resected lung cancer will develop distant metastasis. There remains an u...
Incidental diagnosis of clonal hematopoiesis among healthy, unrelated, hematopoietic stem cell donors: A feasibility study of psychosocial, ethical, and clinical issues
Abstract The overall goal of this line of research is to examine the psychosocial, ethical, and clinical implications of incidental medical findings of clonal hematopoiesis (CH) in...
Redox Regulation of Sarcoidosis Granulomas and Fibrosis
PROJECT SUMMARY Sarcoidosis is a pulmonary and systemic granulomatous disease of unknown cause. To better understand disease mechanisms, we have recently established a novel ex viv...