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99,167 grants found
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Integrating Reading and Attention Practices to Maximize Learning for Students with Co-Occurring Difficulties
Project Summary/Abstract Despite decades of research on reading disabilities, the efficacy of existing interventions for improving reading in upper elementary students (Grades 3 –...
Exopolysaccharide regulation in Aggregatibacter actinomycetemcomitans
ABSTRACT A hallmark of the oral bacterium Aggregatibacter actinomycetemcomitans’ biology and infectivity are its ability to form tenacious biofilms. Biofilm formation in the organi...
Examining the impact of state laws on intimate partner violence
Intimate partner violence (IPV) is common with over 7% of U.S. women reporting physical or sexual violence, and/or staking in the past year. Moreover, nearly 10% of pregnant people...
Concurrent eradication of pathogenic plasma cells and their precursors in systemic lupus erythematosus
PROJECT SUMMARY Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. 90% of patients with SLE are women between the ages of 15 and 44. SLE is characterized by a hype...
Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer
PROJECT SUMMARY/ABSTRACT Our team’s long-term goal is to promote the health and well-being of “metavivors,” a growing population of individuals living long-term with metastatic can...
Determine the Role of Histone Methyltransferase ASH1L in Metastatic Prostate Cancer
Metastasis is the major cause of cancer mortality. Effective therapies are urgently needed for patients with metastatic diseases. Increasing evidence suggests that interactions bet...
A Randomized Trial of Chatbot for Prenatal Genetic Counseling
PROJECT SUMMARY Current recommendations from the American College of Obstetricians and Gynecologists (ACOG) call for all pregnant people to be offered screening and diagnostic test...
Dietary alteration of n-6 and n-3 fatty acids for chronic low back pain
ABSTRACT The NIH has declared that developing new non-addictive treatments for chronic pain is one of its top priorities. Certain polyunsaturated fatty acids are precursors to oxyl...
Mechanisms of Motor Superperformance
MECHANISMS OF MOTOR SUPERPERFORMANCE: ABSTRACT Clinical experience and world population-level data indicate that most neurological disability stems from motor dysfunction. Yet, spo...
Enabling comprehensive and user-friendly circular RNA analyses with circtools.cloud
Project Summary/Abstract Circular RNAs (circRNAs) have been studied for only one decade but have been implicated in many different disease settings such as cancer, neurological, an...
Molecular mechanisms in sweat gland innervation
PROJECT SUMMARY Eccrine sweat glands are the most abundant glands in human skin and are essential for thermoregulation and water balance. Patients with severe burn injuries and con...
Circulating metabolites as novel risk biomarkers for gastric cancer: a large multi-center prospective investigation
ABSTRACT Gastric cancer is one of the most common and deadly cancers globally, accounting for over one million new cancer diagnoses and 783,000 deaths in 2018. Infection of Helicob...
A Novel Personalized Flow Modeling Paradigm for Fetal Aorta and Its Validation with Fetal Cardiac MRI
Congenital heart disease (CHD) is the most common birth defect and a leading cause of death and chronic illness in newborns, infants, and children. Prenatal screening and identific...
Extraction and summarization of evidence-based medicine
Project Summary/Abstract Evidence-based medicine (EBM) requires collecting and ranking relevant evidence according to its epistemological strength, aiming to identify the most suit...
Leveraging cell-derived bioparticles for macromolecular delivery
7. PROJECT SUMMARY/ABSTRACT Many emerging therapeutic strategies employ macromolecules, like proteins or RNAs, to manipulate intracellular contents and processes, thus mitigating d...
Response and resistance to chimeric antigen receptor T cell therapy in human solid tumors using spatial multi-omics
Project Summary Engineered T cells that express a chimeric antigen receptor (CAR) specific to tumor antigens have shown exceptional efficacy in hematologic malignancies. However, t...
The Behavioral Cost of Carbon
PROJECT SUMMARY The objective of this project is to generate the first empirical estimate of the behavioral cost of carbon – the human health-related behavioral impacts imposed by...
Juggling Roles: A Study of Diverse Neonatal Intensive Care Unit Parents and Their Work-Family Transition
PROJECT SUMMARY / ABSTRACT Preterm infants are at a heightened risk for developing neuromotor, cognitive, and psychiatric disorders that persist through adulthood. Infants born ver...
Predictive modeling of viral RNA cellular behavior
PROJECT SUMMARY/ABSTRACT Modern biomedical science enjoys an unprecedented ability to identify and describe viral pathogenic mechanisms, as well as characterize the biomolecular co...
Virginia Accountable Health Equity and Action Dashboard (VA-AHEAD): Community Framing of Equity Data to Support Clinical and Translational Science
VIRGINIA ACCOUNTABLE HEALTH EQUITY AND ACTION DASHBOARD: COMMUNITY FRAMING OF EQUITY DATA TO SUPPORT CLINICAL TRANSLATIONAL SCIENCE PROJECT SUMMARY Disease burden, healthcare deliv...