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99,167 grants found
Showing 4,941 – 4,960 of 99,167 grants
Harnessing the potential of pharmacological small molecules to amplify VSV-based oncolytic viral therapy
Abstract Malignant cutaneous melanoma is the most lethal form of all skin cancers causing 10,000 deaths annually in the United States and 200,000 globally and remains a major oncol...
Immunosurveillance of breast glands with oncogenic germline mutations
Project Summary/Abstract The overarching goal of the proposed research is to realize the immune system's potential for breast cancer prevention in BRCA mutation carriers. Immu...
Development of novel TGR inhibitors for the treatment of schistosomiasis
PROJECT SUMMARY/ABSTRACT Schistosome parasites infect 200 million people, resulting in significant morbidity and more than 200,000 deaths annually. Schistosomiasis control strategi...
Implementation of Comprehensive Survivorship Care Intervention Across FQHC-Based Primary Care Practices
Implementation of a Comprehensive Survivorship Care Intervention Across FQHC-Based Primary Care Practices PROJECT SUMMARY Cancer survivorship challenges adversely contribute to can...
Staphylococcus aureus and eicosanoid dysregulation as drivers of inflammation in aspirin-exacerbated respiratory disease
PROJECT SUMMARY Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by asthma, nasal polypo- sis, and acute respiratory reactions to known cyclooxyg...
Novel treatments of fracture repair and bone pain
SUMMARY Chronic pain and disability after bone fracture in the aged population are common. Approaches to pain management following orthopaedic surgery often include the use of opio...
Novel Hamster Models of Chikungunya Viral Arthritis
PROJECT SUMMARY Chikungunya virus (CHIKV), a mosquito-borne RNA virus, causes chikungunya fever (CHIKF), typically accompanied by severe, debilitating and often chronic arthralgia....
Inhalational therapy with spectinamides within new regimens of TB therapy
To cure and control Tuberculosis (TB) disease we need shorter, simpler and safer therapies. The goal is to develop therapies of low pill burden; of shorter duration (ideally 2-3 mo...
Persistence of HIV-specific CD8+ T cell responses after long-term ART in early treated Thai children
PROJECT SUMMARY Early initiation of antiretroviral therapy (ART) in perinatally infected infants diagnosed with HIV helps to reduce morbidity and mortality, but it is not sufficien...
Neutrophil subpopulations and NETosis in HIV-1 pathogenesis
Despite the success of antiretroviral therapy (ART), cardiovascular (CVD), liver (LD), and other chronic diseases increasingly replace AIDS-related complications as the most common...
Mechanisms of genetic variants in TH2 autoimmunity
PROJECT SUMMARY Monogenic autoimmune diseases, while rare, offer a unique opportunity to develop models that enable a more mechanistic understanding of the disease process, in part...
Engineering mRNA encapsulated extracellular vesicles for in vivo chimeric antigen receptor macrophage therapy for glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is the most common and lethal primary central nervous system cancer in adults, where treatments are ineffective and often debilitating. Unlike ma...
Testing the role of belief updating in persecutory delusions
Persecutory delusions, or the strongly held belief that others intend me harm, are distressing and disabling transdiagnostic symptoms. They are the most common manifestation of del...
The Regulatory R-loops in Pluripotency, Early Development, and Tissue Homeostasis
PROJECT SUMMARY R-loops are three-stranded nucleic acid structures composed of an RNA-DNA hybrid and a free single-stranded DNA. The opened DNA strands may lead to DNA damage; thus...
Deconvolving the language of protein binding
Project Summary/Abstract The ability for transcription factors to achieve specificity in the nucleus is critical for proper gene regulation. Mis-targeting of protein binding can di...
Sex differences in circadian output signaling
PROJECT SUMMARY/ABSTRACT Circadian rhythms are the backing track to the symphony of life. Circadian rhythms not only allow organisms to coordinate their behavior and physiology wit...
IRES-mediated translation: mechanisms and applications in mRNA therapeutics
SUMMARY Protein synthesis is primarily regulated at the initiation stage, allowing rapid and reversible control of gene expression. Whereas cellular mRNAs require a 5′ cap to initi...
Neuroprotective lipid mediators target penumbra in experimental ischemic stroke
Abstract Ischemic stroke is a leading cause of long-term disability in both genders and lacks effective therapeutic options. We propose to study elovanoids (ELVs), which are stereo...
Neuro-Immune mechanisms against skin-penetrating helminths
Neuro-immune mechanisms against skin-penetrating helminths Summary Diverse helminth species establish host infection through direct skin penetration, but the mechanisms of cutaneou...
Electrical Signaling in Dendritic Branches
Spiny projection neurons (SPNs) carry much of the weight of the basal ganglia (BG) information processing. One cell type (dSPNs) contributes to the Direct BG, while the other cell...