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Rapid Point-of-Care Detection of T. pallidum Resistance to Macrolides and Tetracyclines by Multiplexed Loop-mediated amplification (LAMP)
ABSTRACT [30 lines] The continued growth of syphilis cases in the United States is associated with significant maternal-fetal morbidity and mortality, health disparities for racial/...
Modeling Marginal Zone Lymphomagenesis
Project Summary Marginal zone lymphomas (MZL), the second most common subtype of indolent lymphomas, is a B-cell malignancy where the tumor microenvironment plays an important role...
Improving Physical Activity Participation in Latinas with Mindfulness
PROJECT SUMMARY/ABSTRACT Health disparities for Latinas remain a persistent problem leading to increased incidence of chronic disease, comorbidities and premature mortality. The NI...
Discovery of a stem cell governing vertebral physiology
Project Summary Vertebrae and long bones display marked differences across a range of clinical and basic properties, such as their basic architecture, responsiveness to PTH, their...
Targeting base damage repair in BRCA-mutant cancers
PROJECT SUMMARY/ABSTRACT Poly (ADP-ribose) polymerase inhibitors (PARPi) are a mainstay for the chemotherapeutic regimen of BRCA mutant ovarian and breast cancers. Despite initial...
Understanding glial fate restriction in humans
Abstract This proposal aims to determine the mechanisms that lead to the generation of astrocytes in the developing human cortex. Astrocytes are the most abundant cell type in the...
Leveraging glycan-metabolite interactions to shape structure and function of the gut microbiome
SUMMARY. From initially cataloging the microbiome, we can now causally link specific strains and metabolites of the microbiome with protective and pathogenic roles in a broad range...
Uncovering the role of hypothalamic ciliary cAMP signaling in sex-specific control of metabolic homeostasis
Project Summary / Abstract Despite similar obesity rates in both sexes, the underlying biology of excessive weight gain in women and men is believed to differ significantly. Neuron...
The role of colonic tuft cells in microbial detection and mucosal immunity
Project Summary Parasitic worms constitute a major global public health burden, with approximately one-fifth of the human population harboring one or more species within their gast...
Functional synergistic perilaryngeal muscle network using synchronized multi-sensor surface electromyography to improve diagnosis and treatment of voice disorders
Project Summary/Abstract There is a significant gap in understanding and quantifying vocal hyperfunction, a common symptom in patients with phonotraumatic and nonphonotraumatic dys...
PKA-Dependent Autophagy Control in Aspergillus fumigatus Pathogenesis
Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is a leading infectious cause of death in immunocompromised patients. A significant barrier to deciphering...
Mitochondrial Transfer to Treat SBMA Motor Neurons
Project Summary Spinal bulbar muscular atrophy (SBMA) exhibits mitochondrial abnormalities. We and other investigators have shown that mitochondrial dysfunction in SBMA involves bo...
The Golgi complex and HSV entry
Herpes simplex virus (HSV) causes lifelong latent infections in humans.It is responsible for significant disease, ranging from cold sores and genital infections to blindness and fa...
HPV and host factors in juvenile onset recurrent respiratory papillomatosis
ABSTRACT. Patients with juvenile-onset recurrent respiratory papillomatosis (JoRRP) suffer from recurring epithelial papillomas along the respiratory tract caused by low-risk H PV...
Mechanisms of Androgen Receptor Inverse Agonists in Advanced Prostate Cancer
ABSTRACT Nuclear receptors are steroid-dependent transcription factors that confer cell identity and function. They guide development, and maintain homeostasis in adult tissue, suc...
NRF2 suppression of inflammatory signaling and its role in tumor progression
Project Summary/Abstract Tumor metastasis is responsible for the vast majority of deaths from epithelial cancers, including breast cancer. Understanding how cancer cells spread to...
Alternative splicing and isoform expression as mediators for the genetic etiology of breast cancer
ABSTRACT A drawback of genome-wide association studies (GWAS) for breast cancer risk and related phenotypes is their limited insights into genotype-to-phenotype mechanisms for iden...
The resurgence of antibody-drug conjugates via PMPC-polymer engineering
Project Summary: We have patented a novel polymer-based in vivo-delivery platform for therapeutic antibodies using a super- hydrophilic polymer, poly 2-methacryloyloxyethyl phospho...
Hydrogel matrices to study the role of inflammation and biological sex on aortic valve fibrocalcification
ABSTRACT Thirteen percent of adults over 75 suffer from aortic valve stenosis (AVS), a progressive disease that leads to aberrant collagen deposition, leaflet stiffening, and event...
Analysis of cord blood Vd2 T cell differentiation and function using CITE-seq and ATAC-seq
PROJECT SUMMARY Infants are especially susceptible to infectious agents, in particular intracellular pathogens, which require mounting a Th1 response for immune protection. The fac...