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99,167 grants found
Showing 4,901 – 4,920 of 99,167 grants
Statistical Methods for Precision Environmental Health with Mixture Exposures
Project Summary/Abstract Precision environmental health focuses on individual risk assessment to inform targeted disease prevention strate gies. Identifying individuals with incre...
SCH: Synergizing Topological Deep Learning and Spatio-Temporal Causal Inference to Unpack Health
PROJECT SUMMARY (See instructions): This research aims to provide novel statistical and deep learning (DL) tools to address open methodological challenges in understanding and miti...
Mechanisms and Therapeutics for Congenital Aortic Valve Disease
Abstract Diseases affecting the heart valves are among the most common type of cardiovascular medical condition affecting 2.5% of the population in the United States. The aortic va...
Evolution of Salmonella in a cockroach vector
PROJECT SUMMARY Salmonella enterica serovar Typhimurium is a widespread human enteric pathogen that has a broad range of animal hosts and environmental reservoirs. Meanwhile, the G...
Defining the immunogenic landscape of early mosquito-stage P. falciparum to accelerate malaria transmission-blocking vaccine discovery
PROJECT SUMMARY The disease malaria is caused by vector-borne parasites of the genus Plasmodium. With hundreds of millions of infections and over half a million deaths annually, ma...
Systematic CRISPR Analysis of EBV Lymphoma Resistance Pathways to Natural Killer Cell Lysis
Abstract Epstein-Barr virus (EBV) causes lymphomas at greatly increased frequency in people living with HIV/AIDS, including diffuse large B-cell lymphoma, primary CNS lymphoma, Hod...
Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU Y18 Supplement
Project Summary/Abstract The Clinical Trials Unit (CTU) in Botswana conducts research related to adult and pediatric HIV therapeutic strategies; interventions to address HIV-associ...
Epigenetic regulation of transcriptional programming
ABSTRACT Cell type-specific transcriptional programming enables a single fertilized egg to make the remarkable transition to become a multicellular organism. The requisite sequence...
Cell cycle and checkpoint variations in development and disease
Project Summary The Calvi lab investigates the regulation of cell cycle and genome integrity using Drosophila melanogaster as a model system. Our ongoing studies are defining the v...
METTL3 in Cardiac Benefits of Exercise in Diabetes
Summary / Abstract Diabetic cardiomyopathy is a major complication and the leading cause of death and disability in patients with diabetes. Effective treatment to improve outcomes...
Mediator kinase regulation of cardiac transcription
Project Summary/Abstract Hypertension is a common chronic heart condition resulting in cardiac hypertrophy, dysfunction and heart failure. Mediator kinase, Cdk8 expression is incre...
Rewiring Cancer-Induced Abnormalities in the Vascular Barrier
Summary Tumors are known to induce the formation of unique microenvironments in distant organs that facilitate seeding, survival, and growth of metastatic nodules. These sites, kno...
Control of precisely timed gene expression during notochord development by Brachyury
PROJECT SUMMARY/ABSTRACT Precise temporal regulation of stage-specific gene expression is fundamental for the proper development of all organisms. Different molecular mechanisms th...
SARS-CoV-2 and Social Determinants of Health Impact on Inflammation Associated Depression Risk (SSIDR)
PROJECT SUMMARY A Global Burden Disease survey commissioned by the World Health Organization (WHO) estimated a 27.6% increase in cases of major depressive disorder (MDD) during the...
Identification and validation of LPA/LPAR signaling as a target for the treatment of temporomandibular disorder pain
ABSTRACT Current pharmacologic therapies for TMD pain are largely ineffective and plagued with side effects because their mechanisms of action to TMD pain have not been validated....
Multimodal regulation of intracellular lipid surveillance
Project Summary/Abstract Lipid signaling is crucial for regulating organismal physiology and metabolic expenditure, and disturbances in lipid homeostasis can deleteriously impact h...
Development of CNS-Active 5-HT3R Antagonists for the Treatment of Neuropathic Pain
PROJECT SUMMARY/ABSTRACT Neuropathic pain (NeuP) affects 6-8% in the adult population. It leads to substantial functional impairment and has deleterious impact on patients’ quality...
1/2 A Brief Automated Neurocognitive Training to Enhance the Real-World Impact of Ketamine's Rapid Antidepressant Effect
Project Summary. Intravenous ketamine, which displays rapid antidepressant properties, is posited to reverse symptoms by rapidly enhancing neuroplasticity. Although community-based...
Characterization of vsp/vlp system of Borrelia recurrentis
PROJECT SUMMARY Louse-borne relapsing fever (LBRF) is a strictly human disease caused by louse-borne Borrelia recurrentis. To date, LBRF has been a significant burden in several Af...
Therapeutic targeting for translocation renal cell carcinoma
SUMMARY Translocation Renal Cell Carcinoma (tRCC) represents a rare subtype of kidney cancer associated with aggressive behavior and poor clinical outcome. The prevalence of this d...