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99,167 grants found
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Self-administered microneedle patch for long-acting release of antiretroviral agents
ABSTRACT OF PROPOSED RESEARCH Antiretroviral agents (ARV) have proven successful in preventing new HIV transmission and improving survival and quality of life in people living with...
Controlling and Preventing Asthma Progression and Severity in Kids with Omalizumab Extension (PARK-EXT)
Project Summary/Abstract Asthma is the #1 chronic disease in childhood: prevention is an unmet need and pressing priority. We are conducting the first randomized, double-blind, pla...
Ethanol modulation of a NE-astrocyte-DA arousal pathway
Project Summary Alcohol Use Disorder (AUD) is a highly prevalent public health problem for which there are few effective treatments. Sleep disturbances are highly comorbid with AUD...
Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental Disorders
PROJECT ABSTRACT The millions of brain MRIs acquired each year in clinical settings are a vastly underutilized scientific resource. Meanwhile, brain MRIs collected in research stud...
Influence of an E. coli hyperadherent probiotic on Salmonella intestinal colonization
Project Abstract Salmonellosis continues to be one of the most important causes of food-borne illness in the U.S. Furthermore, multiple-antibiotic resistant Salmonella strains are...
Integrated movement tracking for pediatric OPM-MEG studies of intellectual disability
Abstract This R61/R33 project will develop an advanced technology for non-invasive recording of whole-brain physiology with synchronized video-tracking of movement for use in child...
Respiration and fitness in Bacteroides
PROJECT SUMMARY/ABSTRACT Bacteroidales is the most abundant order of bacteria in the human gut, yet we still know little about energy generating processes of these bacteria and how...
The role of C/EBPß in sepsis associated acute-on-chronic liver failure
PROJECT SUMMARY Acute-on-chronic liver failure (ACLF) is a clinical syndrome in which there is rapid development of liver and multi- organ system failure in a patient with previous...
Material Stiffness Directs Oral Cancer Migration
Project Summary Oral squamous cell carcinoma (OSCC) is the sixth most common epithelial cancer worldwide with 50,000 new cases/year in US. Despite being less frequent, survival rat...
KanSurvive 2.0
Project Summary/Abstract Cancer survivors require long-term and coordinated care to address the physical, emotional, and psychosocial effects of cancer and its treatment. Rural can...
RNA modification and innate immune activation in HIV infection
PROJECT SUMMARY People living with HIV (PLWH) on anti-retroviral therapy (ART) still suffer from HIV-associated non-AIDS complication (HANA) such as neurocognitive disorders. Altho...
A national Asian American cohort for assessing multi-level determinants in cancer etiology: the ASPIRE Cohort
Abstract Asian Americans are the fastest growing and most diverse U.S. racial/ethnic group. They have unique and disparate patterns of cancer, including being the first U.S. racial...
Impact of NAFLD on Metabolic Brain Function via CEST MRI in HIV-Positive Individuals
Liver-related complications continue to pose a significant threat to the health of people living with HIV (PLWH), despite the life-extending benefits of combination antiretroviral...
A Remotely delivered Tai Chi/Qigong Intervention for older people living with HIV: A Randomized Clinical Trial
Project Summary Half of those living with HIV in the United States are over 50-years of age. As people living with HIV (PWH) live longer with the disease, the tradeoff is that they...
Decoding Mechanisms of Nonsense-mediated mRNA Decay through Alternative Splicing
SUMMARY The human genome preserves a strict regulation of gene expression to maintain physiological integrity. RNA processing plays a key central role in this regulation and has dr...
Cilia-mediated mechanisms of viral entry into nasal mucosa
Project Summary Human respiratory tissues have a unique cellular architecture and a mucus-based clearance system that, together, constitute an impressive barrier to viruses that us...
SCH: Pennsylvania Asthma-COPD Syndromic Surveillance (PASS)
PROJECT SUMMARY (See instructions): Fossil-fuel-related outdoor particulate matter, ozone, and first- or second-hand cigarette smoke collectively afflict over 545 million people gl...
Visitation-based obesogenic environment measurement: A novel instrument using Big Data approach
Abstract. Obesity is a predictor of multiple negative health outcomes, including type 2 diabetes, coronary heart disease, hypertension, various cancers, and premature death. Today,...
The role of Nrf2 in T cell function and influenza
Despite considerable efforts toward vaccination, influenza and its complications continue to kill tens of thousands of people annually in the U.S., making it the eighth leading cau...
Mechanisms of CNS myelin targeting
Project Abstract: Efficient vertebrate nervous systems require the precise insulation of central nervous system (CNS) axons by myelinating oligodendrocytes. However, we know very l...