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99,167 grants found
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Deciphering how the Cas2 ribonuclease non-canonically controls Legionella pneumophila thermal tolerance and virulence
PROJECT SUMMARY / ABSTRACT Legionella pneumophila (Lp) is the agent of Legionnaires’ disease. In water systems, Lp grows in amoebae and biofilms, and in the lungs, it infects macro...
Melanocyte PDL1 control of UVB-induced IFN-I
This new R01 proposal assembles a team with expertise in tumor immunology and immunotherapy, mouse cancer models, melanoma, IFN-I signals, tumor signaling, single cell spatial omic...
Integrating Breast Cancer and Cardiovascular Disease Risk to Explore Decision-Making for Chemoprevention Among Racially/Ethnically Diverse Women at High Risk for Breast Cancer
Women with high-risk breast lesions, such as atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS), have up to a 4- to 10-fold increased risk of invasive breast cancer (BC...
Targeting Endothelial Epsins to Ameliorate Myocardial Ischemia
PROJECT SUMMARY/ABSTRACT Lack of oxygenation and nutrients that result from narrowed arteries and reduced blood flow debilitates the normal function of the heart, leading to severe...
Deciphering the significance of pathogen genetic variation and evolution
PROJECT SUMMARY Using a combination of genetics and experimental evolution, our team seeks to understand complex epistasis with respect to genetic background in the human pathogen...
Investigating a Novel Inhibitory Receptor in Regulating CAR-T Cell Persistence and Function
ABSTRACT Chimeric antigen receptor (CAR)-engineered T cell therapy is a breakthrough immunotherapy for lymphoma. Nevertheless, 40-60% of responding patients relapse, in part due to...
Neural mechanism of reward processing in autistic adolescents
PROJECT SUMMARY Social deficits are a primary characteristic of autism spectrum disorder (ASD). The social motivation hypothesis posits that these deficits reflect alterations in s...
Role of hypothalamic MAGEL2 in motivation
Prader-Willi Syndrome (PWS) is a neurogenetic disorder caused by the loss of paternal expression of a cluster of genes in the human 15q11-q13 region. Among the genes in the PWS del...
Couples' Communication about Sexuality when Facing Metastatic Breast Cancer
7. PROJECT SUMMARY/ABSTRACT Cancer diagnosis, treatment, and management can challenge romantic relationships. For individuals in committed partnerships, cancer is a dyadic endeavor...
Analysis of CTCF Function in Neurodevelopment
Project Summary/Abstract Neurodevelopmental disorders (NDD) are a broad category of congenital neurological disease characterized by a wide range of cognitive and behavioral impair...
Development and optimization of skeletal muscle delivery vehicles
Project Summary/Abstract Correction of genetic muscle diseases, such as the muscular dystrophies, is a unique problem due to the distribution of muscle throughout the body in inacc...
Targeting Arc to Improve Cognitive Deficits in Psychotic Disorders
PROJECT SUMMARY The degree of cognitive impairment is the best predictor of functional outcomes in schizophrenia, but the efficacious treatment of these deficits remains a signific...
Development of a Bioengineered Therapeutic Device for the Prevention of Lymphedema
ABSTRACT: Lymphedema affects approximately 200 million patients globally, and it is characterized by the accumulation of lymph fluid in soft tissues due to obstructions in the lymp...
Cortical Networks Encoding Higher-Order Memories that Elicit Fear
Project Summary Exposure to traumatic events can result in intrusive fear memories that can be evoked not only by stimuli that were present during the event, but also by stimuli th...
A Novel Janus Bead Blood Assay for Point-of-Care Assessment of HCV Viral Load and Associated Liver Damage
Project Abstract Globally, nearly 300,000 people die from hepatitis C virus (HCV) related liver diseases, most of them in developing nations with poor resources. Until the recent C...
Understanding early developmental trajectories of, and mechanisms underlying, sensory reactivity in infants at familial risk for ASD and ADHD
PROJECT SUMMARY Individuals with autism spectrum disorder (ASD) often show altered responsivity to incoming sensory stimuli (i.e., hyper-reactivity, hypo-reactivity, sensory seekin...
Targeting transcriptional addiction in fusion-driven sarcoma
7. Project Summary/Abstract The overarching goal of this NGC Center is to leverage expertise in small molecule drug discovery, target identification, and protein and IDR biochemist...
Evaluating the role of SPAK and OSR1 kinases in glioblastoma chemotherapy resistance
Project Summary Glioblastoma (GBM) is the most devastating brain neoplasm with high morbidity and mortality. Despite multimodal treatment including surgery, radiotherapy, and chemo...
Designer extracellular vesicles for cancer therapy
SUMMARY This proposal aims to translate our engineered extracellular vesicles (EVs) into an effective cancer therapy. Major barriers to effective chimeric antigen receptor (CAR)-T...
Investigating the impact of chromosomal instability on prostate cancer aggressiveness
PROJECT SUMMARY Prostate cancer (PC) is a leading cause of male cancer-related deaths. Once disseminated PC is incurable as it gradually progresses to all therapeutic options. The...