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99,167 grants found
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Ultra-Small Epigenetic-Regulating Nanocarrier for Enhanced Synthetic Lethal Therapy
Project Summary: PARP inhibitors-based synthetic lethal therapy, such as BMN673 (Talazoparib), shows great efficacy for BRCA mutated (or homologous recombination repair (HRR)-defic...
Effectiveness of the HPV Vaccine in Immunocompromised Populations
PROJECT SUMMARY/ABSTRACT Immunocompromised individuals—such as people with HIV (PWH), autoimmune conditions, and a history of solid organ or hematopoietic stem cell transplantation...
Development of murine glioblastoma model for oncolytic HSV therapy
The overall goal of this project is to create a murine-models for grade IV brain tumors that will be sensitive to HSV-1 infection and can be utilized to evaluate oncolytic HSV-1 (o...
Intensive longitudinal assessment of human olfaction
Summary Olfactory (i.e., smell) disorders are incredibly impactful. Gas leaks and spoiled food are undetectable dangers. Eating habits and the pleasure from food are compromised as...
Development of novel anticoagulant antidotes using zebrafish
PROJECT SUMMARY/ABSTRACT Superwarfarins are 4-hydroxycoumarin derivatives that are well known to interfere with blood coagulation, specifically through inhibition of vitamin K epox...
Circadian Regulation of Cardiac Electrophysiology
Abstract. Circadian clocks play a fundamental role in aligning physiological and behavioral processes to predictable changes in the daily environment. For decades, circadian signal...
Limiting Dysglycemia Around Physical Activity for People with Type 1 Diabetes Using Activity-Aware Automated Insulin Delivery – the APEX Project.
In this project we aim to transform glycemic control during physical activity (PA) among persons with Type 1 diabetes (PwD) by testing three novel complementary approaches toward a...
Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
PROJECT SUMMARY/ABSTRACT Overview: The goal of this project is to assess the efficacy of a tailored phone-delivered positive psychological intervention (PATH) for improving anxiety...
Defining signatures of epigenetic sensitization to lung cancer in a mouse model
PROJECT SUMMARY Epigenetic perturbations in cancer are widely recognized but poorly understood. A detailed understanding of how latent epigenetic information contributes to tumorig...
Brevetoxins and Emergency Encounters among Children (BEECH)
PROJECT SUMMARY Algal blooms - the rapid growth of photosynthetic organisms in water - endanger human health, but there is a stunning lack of data regarding effects on children. Th...
Optimizing air purification strategies to reduce household PM2.5 exposure in Uganda
PROJECT SUMMARY While control of emissions is the most effective method of reducing air pollution exposure, people living in low and middle-income countries (LMICs) are often expos...
Integrating Genomic Signatures with Functional Analysis of DNA repair
PROJECT SUMMARY Genome instability is the underlying cause of many diseases including premature aging, neurodegeneration, cancer, and immunodeficiency. Genome integrity is maintain...
Estimating Overdiagnosis After Implementation of Lung Cancer Screening in Community-Based Healthcare Systems
PROJECT SUMMARY/ABSTRACT Low-dose computed tomography (LDCT) has been accepted as an efficacious population-based approach for lung cancer screening (LCS) based on findings from th...
3D Printing of Air: An Intangible Ink for Fabrication of Vascularized Tissues
PROJECT SUMMARY/ABSTRACT Three-dimensional (3D) bioprinting has been making a revolutionary impact on building living tissues and organs. Despite several attempts, vascularization...
Cardiomyocyte selective modulation of natriuretic peptide signaling in cardiomyopathy
Project Summary: In the last 30-years there has been a dramatic increase in our understanding of the genetic and non-genetic mechanisms that contribute to the development of cardio...
Parasite variant surface antigen expression and immune gaps in severe malaria
PROJECT SUMMARY Severe malaria kills hundreds of thousands of children across sub-Saharan Africa annually, accounting for most malaria-related deaths globally. We have not yet iden...
GLT-1/EAAT2 signaling as a novel player in myelin repair
Multiple Sclerosis (MS) is a progressive inflammatory demyelinating disease that affects the central nervous system (CNS), and it is considered the most common non-traumatic debili...
Mitigation of erythrocyte adhesion in human malaria
Abstract Malaria is one of the world’s most common and deadly infectious diseases. Approximately 627,000 people, mostly African children, die each year due to complications of mala...
Developing KSHV-Infected Lymphatic Endothelial Cell-Based Models of Kaposi’s Sarcoma
PROJECT SUMMARY Kaposi’s Sarcoma-associated herpesvirus (KSHV) causes the AIDS-defining cancer Kaposi’s Sarcoma (KS). How KSHV infection causes KS is poorly understood, primarily d...
Small molecule inhibitors of Slit2/Robo signaling as novel therapeutics for glioblastoma
PROJECT SUMMARY/ABSTRACT: Glioblastoma (GBM), the most prevalent malignant primary brain tumor, is an extremely aggressive form of diffuse glioma originating from astrocytic lineag...