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99,167 grants found
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15-PGDH-Mediated Eicosanoid Degradation in Cardiac Fibrosis and Heart Failure
Project Summary/Abstract Fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in tissue scarring and organ dysfunction. In the heart, fibrotic remodeli...
Neural circuit basis of safety learning
ABSTRACT Learning about and using environmental cues for safety is critical for survival and mental wellbeing. Current research on safety signals identifies the basolateral amygdala...
Role of hippocampal HCN Channels in social avoidance
Contact PD/PI: Kim, Chung Sub Abstract Social stress in humans increases the risk of mental health problems. Individuals who experience physical and/or emotional bullying display a...
Air Pollution Exposure and Risk for Cerebral Palsy - A Statewide Study
PROJECT SUMMARY/ABSTRACT Cerebral palsy (CP) is the most common life-long neuromotor physical mobility. CP affects about1 in 345 newborns each year condition that permanently affec...
Impact of early childhood malaria prevention on malaria risk at school entry (ERASE)
Project Summary The World Health Organization (WHO) recommends two key interventions to protect young children in sub-Saharan Africa from Plasmodium falciparum (Pf) malaria morbidi...
Structural mapping of an immunodominant antigenic site on the norovirus capsid
PROJECT SUMMARY Noroviruses are a top cause of acute gastroenteritis globally, and no approved norovirus vaccine exists. The norovirus capsid protein plays key roles in virus attac...
microRNA regulation of NMNAT-mediated Neuroprotection against Peripheral Neuropathy and Chronic Pain
PROJECT SUMMARY Peripheral neuropathy and neuropathy pain can be caused by a myriad of genetic and environment factors as well as therapeutic or recreational drug use. Chemotherapy...
Quantifying genomic and pharmacometabolomic differences in antiretroviral exposure in MACS/WIHS Combined Cohort Study
PROJECT SUMMARY/ABSTRACT A key challenge in medicine is identifying individuals who will benefit the most from treatment. Despite the effectiveness of combination antiretroviral th...
Feasibility and Efficacy of Ambulance-Based mhealth for Pediatric Emergencies (FEAMER) Trial
Introduction: The overall goal of our research project is to reduce the mortality and morbidity of children with acute and emergency illnesses by improving care during ambulance tr...
Neural and computational mechanisms of motivation and cognitive control
PROJECT SUMMARY/ABSTRACT Most daily tasks demand cognitive control, but people vary in their motivation to meet the control demands required of those tasks. Motivational impairment...
When alternative splicing meets cytoskeleton organization, local translation, and transcription regulation
ABSTRACT / SUMMARY Alternative splicing is an RNA processing mechanism that explains how single genes can produce more than one transcript. Alternative splicing is a rule rather th...
Disentangling the role of culture, life stage, and information design to facilitate equity in data report back
Project Summary/Abstract The environmental justice (EJ) framework highlights the social, political, and economic assumptions contributing to and producing unequal protection in EJ...
The effects of immunosuppression on SARS-CoV-2 persistence, virus genetic diversity and clinical outcomes of COVID-19
ABSTRACT One of the biggest challenges for the development of Coronavirus Disease 2019 (COVID-19) vaccines and therapeutics is the emergence of SARS-CoV-2 variants with immune-esca...
Procession to IND of a capsid mutated AAV8 codon optimized NAGLU vector for treatment of Sanfilippo Syndrome type B
Procession to IND of a capsid mutated AAV8 codon optimized NAGLU vector for treatment of Sanfilippo Syndrome type B. Project Summary The AAVtcm8-coNAGLU vector is able to correct t...
Cortical information loss in diffuse low-grade glioma infiltrated cortex
Project Summary/ Abstract. Glioma, the most common primary brain tumor in adults, is a major cause of neurological morbidity and mortality, with no effective therapies. Low-grade g...
Genetic and neural mechanisms of paternal care behavior
Project Summary/Abstract: The degree to which behavioral variation is shaped by experiences or determined by heritability has long captivated biologists and non-biologists alike. I...
A population-based computational approach for arrhythmia prediction and therapy
PROJECT SUMMARY Sudden cardiac death is primarily caused by ventricular arrhythmias, accounting for nearly half of all cardiovascular disease deaths in the US. However, most of the...
Mechanisms of efficient control of Mycobacterium tuberculosis in the lungs prior to granuloma
PROJECT SUMMARY/ABSTRACT. Novel vaccination strategies are necessary to contain the TB pandemic, as the currently licensed anti-tubercular vaccine, Bacille Calmette-Guerin (BCG), h...
High dimensional motor coding and motor dysfunction in Rett syndrome
Project Summary/Abstract The broad, long-term goals of the proposed research are to better understand the neural underpinnings of healthy motor function and motor dysfunction in Re...
Illuminating the role of historical structural racism in the neighborhood exposome and modern-day child mental health
ABSTRACT Disadvantaged neighborhoods are important predictors of internalizing and externalizing behaviors (INT/EXT) in children, including depression, anxiety, ADHD, and conduct p...