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Mechanisms of signaling interaction between endocardium and myocardium
Communication between the myocardium and endocardium, separated by a layer of cardiac jelly, is essential for heart morphogenesis, especially trabecular formation. Trabeculae are s...
Preparing for Obesity Treatment Optimization: A Mixed Methods Study with Transition-Age Autistic Youth
PROJECT SUMMARY/ABSTRACT Obesity can pose a lifelong threat to health and quality of life for many autistic people. Across the lifespan in autism, obesity prevalence is increased r...
Therapeutics that Correct the Underlying Cause of Smith-Magenis Syndrome (SMS)
Project Abstract Smith-Magenis syndrome (SMS) is an autosomal dominant neurodevelopmental disorder characterized by the deletion of one Rai1 allele (Retinoic Acid Induced-1). As a...
Executive Function Intervention for Young Children with Down Syndrome
Abstract Down syndrome (DS) is associated with executive function (EF) challenges throughout the lifespan. Although early intervention has the potential for positive downstream eff...
Alterations to endothelial membrane composition and structure as a driver of the endotheliopathy of trauma
Project Abstract Severe hemorrhage is a life-threatening condition that often occurs in trauma. Hemorrhagic shock and the hypotension and tissue ischemia that results is associated...
School Environment as a Social Driver of Youth Mental Health Trajectories in Mwanza, Tanzania
SUMMARY. Mental health problems are a leading cause of disability among children worldwide and in Tanzania where research has documented high rates of youth depression, anxiety, an...
The effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvessels
Combined antiretroviral therapy (cART) suppresses HIV replication, but 30-60% of infected patients suffer from severe HIV-1 associated neurocognitive disorders (HAND). However, the...
Optimizing the diagnostic approach to cephalosporin allergy testing (DACAT Trial)
PROJECT SUMMARY In the United States, beta-lactam antibiotics are the leading cause of allergic reactions. Cephalosporin antibiotics, in particular, are the most common cause of dr...
Validation of electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention
PROJECT SUMMARY Sustained attention, the ability to focus on an activity or stimulus over time, is impaired in many brain disorders. Targeting attentional deficits for treatment is...
Molecular interactions and regulatory events in telomere maintenance
PROJECT SUMMARY/ABSTRACT All genetic information is stored in DNA that is intricately wrapped by proteins to form chromosomes. Telomeres are the nucleoprotein complexes that cap an...
3D wearable NIR spectral tomography for early prediction of breast cancer’s residual cancer burden after neoadjuvant chemotherapy
Prediction of Residual Cancer Burden (RCB) early in treatment can enhance long-term survival outcomes for breast cancer patients undergoing neoadjuvant chemotherapy (NAC) and their...
Machine Learning Models for Studying Protein Interactions in the Context of Immune Receptors
Project Summary / Abstract Protein interactions are the fundamental basis of all cellular processes. Proteins interact with each other to form complexes that carry out a wide range...
The role of hepatic Endoplasmic Reticulum architecture in metabolic homeostasis and disease
ABSTRACT:Metabolic dysfunction Associated Fatty Liver Disease (MAFLD) is the most common chronic liver disease, yet treatment options are limited. Within hepatocytes, the endoplasm...
Molecular Functions of BRCA2 and RAD51 Paralogs in Homologous Recombination and Chromosome Maintenance
Project Summary/Abstract The broad objective of this proposal is to understand the molecular mechanism of homologous recombination (HR) in humans, and to understand how the consequ...
Intracellular Vitamin D to Combat Instant Blood-Mediated Inflammatory Reaction
PROJECT/SUMMARY ABSTRACT The objective of this proposal is to assess a nanotherapeutic for the treatment of islet transplantation associated instant-blood-mediated inflammatory rea...
ELUCIDATING MECHANISMS OF THORACIC AORTOPATHY VIA COMPUTATIONAL MODELING
PROJECT SUMMARY Thoracic aortopathy – aneurysm, dissection, and rupture – is increasingly responsible for morbidity and mortality in younger (having genetically predisposed lesions...
Assessing Urban-Rural Environmental Stress Inequities in ADRD through Ecological Momentary Assessment
This study aims to identify and understand the role of environmental stressors in the development of Alzheimer’s Disease-Related Dementias (ADRD) and related health inequities acro...
A QUANTITATIVE, PREDICTIVE MODEL OF VASCULAR REMODELING IN HEALTH AND DISEASE
Summary The vascular system constantly remodels in response to tissue growth or changes in metabolism to efficiently deliver nutrients and oxygen to tissues. Remodeling encompasses...
Role of disparities and aging biomarkers in accelerated cardiac aging among adolescent and young adult cancer survivors
PROJECT SUMMARY AND ABSTRACT Cancer in adolescents and young adults (AYA) is defined as a diagnosis in individuals aged 15-39-years and is diagnosed in approximately 90,000 AYAs ea...
Improved 3D EPI for Pre-Surgical Mapping of Epilepsy
Project Summary In pediatric epilepsy patients with drug-resistant seizures, surgical resection is the most effective treatment option. The goal of resective surgery is to maximize...