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99,167 grants found
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Inflammatory Challenge in Human Aggression
Project Summary: While elevations of circulating pro-inflammatory modulators correlate directly with variables of aggression, and direct application of cytokines to specific cortic...
Therapy for long-COVID in a preclinical model
ABSTRACT New SARS-CoV-2 variants and novel coronaviruses will constantly arise and affect large proportions of the worldwide population. Although the current wave of infections wit...
Enhancing insight into placental dysfunction in common obstetric disorders using placental multiomics
Project Summary Adverse obstetrics disorders, including preeclampsia, preterm birth, and fetal growth restriction, are common worldwide. However, they are difficult to study given...
Hox gene regulation of body size and asexual reproduction underlie regenerative abilities
Abstract The ability of certain animals to regenerate their cells and tissues has long been a subject of interest for biologists due to its relevance to animal development and rege...
Role of prefrontal dopamine circuits in threat avoidance learning
PROJECT SUMMARY Ongoing evaluation of environmental cues that predict aversive outcomes enable animals to avoid threats. However, learned avoidance can easily become maladaptive. E...
Circadian regulation of astrocytic adenosine kinase in the irradiated and cancer brain
ABSTRACT Cranial radiotherapy (CRT) for CNS cancers leads to debilitating cognitive decline that is particularly concerning for pediatric and grade II/III brain cancer survivors. C...
Optimized and accessible immuno-PET using lipid nanoparticle-mediated in vivo bioreactor
Immune-mediated positron emission tomography (immunoPET) is an emerging imaging technique that enables non-invasive in vivo pathology assessment, analogous to what is commonly used...
Identification and application of targeting peptides for systemic nanoparticle delivery to osteoarthritic joints
PROJECT SUMMARY Disease-modifying therapies for osteoarthritis (OA) remain a significant clinical challenge. Though numerous promising drug candidates are discovered, they suffer f...
Translating Evidence into Action: Novel modeling approaches to end the syphilis epidemic in the U.S.
PROJECT SUMMARY Syphilis rates in the United States (US) have reached their highest levels in decades, doubling in the past five years alone. In 2021, men who have sex with men (MS...
Engineered Mesenchymal Stromal Cells for Enhanced Immunosuppression
PROJECT SUMMARY Mesenchymal stromal cells (MSCs) have regenerative, immunosuppressive properties, but using MSCs to treat autoimmunity has resulted in mixed clinical results at bes...
Mechanistic analysis of a pathway that integrates allorecognition and altruism in Dictyostelium
Allorecognition is the ability to discriminate self from non-self or kin from non-kin. It is observed in various processes in every life kingdom, including immunity, development, s...
Mechanism and Regulation of Homologous Recombination in Genome Maintenance
Project Summary DNA double-strand break (DSB) is one of the most toxic DNA lesions in cells. DSB causes immediate chromosome breakage and must be repaired before chromosome segrega...
Systems and Network-level Regulation of Cell Death
PROJECT SUMMARY/ABSTRACT Our lab studies mechanisms that control regulated cell death (RCD). Recent studies have uncovered the existence of 15 distinct forms of RCD. These include...
Characterizing the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens
Project Summary Pathogens are one of the strongest selective pressures on the human genome. As modern humans migrated out of Africa, they encountered markedly different pathogenic...
3' RNA modification enzymes regulate tumor angiogenesis in non-small lung cancer
Lung cancer is the leading cause of cancer-related mortality in the United States, and non-small cell lung cancer (NSCLC) comprises over 80 percent of all types of lung cancer. The...
Understanding the role of Hsp70 phosphorylation in proteostasis
Project Summary Hsp70 is vital molecular chaperone that folds a large proportion of the proteome. Research has primarily focused on how Hsp70 function specificity arises through re...
Transforming Urine Output Tracking in Hospitalized Heart Failure Patients
ABSTRACT: Urine and stool output tracking is essential for hospital treatment of diseases related to the heart, lungs, and blood. For patients who can walk, output monitoring curre...
Regional specific metabolism regulates specification of the Spemann Organizer
Project Summary Congenital heart disease is a major cause of illness in newborns and children. While studying Leigh’s syndrome, a mitochondrial metabolism disease caused by LRPPRC...
The involvement of GPR37L1 on a chronic migraine-like state
ABSTRACT GPR37L1 is a recently deorphanized receptor belonging to the larger family of seven transmembrane receptors that couple through G-proteins to regulate numerous biological...
Long-acting Antiviral Treatment for HBV
ABSTRACT The overarching goal of this collaborative and translational research on hepatitis B (HBV) is to discover a safe and effective long-acting antiviral (ARV) therapy that can...