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99,167 grants found
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Assay Development, Screening and Early Optimization
ABSTRACT Research Component (RC) 3 includes the 1) development of new in vitro and/or ex vivo assays, and 2) screening and/or rational design efforts to identify and characterize n...
Discovery and/or Validation of Pharmacodynamic Markers
ABSTRACT Research Component (RC) 4 includes the development of pharmacodynamic (PD) markers that indicate the molecular target engagement of the pain assets, typically representing...
CCL2/CCR2 modulates HIV-associated ischemic stroke by regulating blood brain barrier monocyte recruitment
ABSTRACT HIV infection results in increased susceptibility to ischemic stroke by enhancing the injury volume and decreasing post-stroke recovery. Stroke is the second leading cause...
Improved delivery of bNAbs for targeting CNS infection in infants
PROJECT SUMMARY Despite the tremendous success of the combination antiretroviral therapy (cART), the persistence of HIV reservoirs remains as the major obstacle to achieve HIV cure...
Genetic and social determinants of pharmacological health outcomes in ancestrally diverse populations (Warren)
PROJECT SUMMARY/ABSTRACT Pharmacogenomics has the potential to dramatically improve health care outcomes, but is currently failing on diversity among its research participants. As...
Epigenetic biomarkers of preeclampsia risk among mothers with chronic hypertension
ABSTRACT Preeclampsia (preE) is a potentially fatal complication of pregnancy that affects 2-8% of pregnancies worldwide. Preeclampsia is characterized by hypertension and proteinu...
Defining the cellular dynamics that orchestrate alveolar epithelial cell repair behaviors in live mammal
PROJECT SUMMARY The mammalian lung has the capacity to repair itself following various injuries. Alveolar repair is a dynamic and coordinated process whereby stem/progenitor cells...
Understanding the biology of disparity-associated genomically stable gastric tumors
PROJECT SUMMARY Gastric cancer (GC) has a high mortality rate in Latinos. This is likely the result of multi-level social determinants of health and population-specific factors. Ou...
Supporting pregnant patients as they face a changing landscape of prenatal genetic tests and post-diagnosis options
ABSTRACT Prenatal genetic screening tests and diagnostic tests (PS&D) contribute to optimal fetal/neonatal outcomes through the delivery of high-quality prenatal care. While PS...
Fight Fatigue: A progressive muscle relaxation and walking intervention to reduce fatigue in adults with ESKD
Project SummaryIn this R34 application, we propose to conduct an early phase clinical trial of a mind-body intervention to promote whole person health—specifically, to develop and...
Cross-brain, multi-region interactions in decision formation and decision commitment
Project Summary/Abstract The brain is composed of many densely interconnected regions, in constant communication and interaction with each other; cognition and behavior emerge from...
Development and Validation of a Mouse Model of Intervertebral Disc Degeneration-Induced Low Back Pain to Facilitate Non-Addictive Analgesic Discovery
PROJECT SUMMARY / ABSTRACT Low back pain (LBP) is a leading cause of disability worldwide with an estimated 40% of LBP attributed to degenerating intervertebral discs (IVD), freque...
Molecular Mechanism of Folding of Nsp12 and Assembly of the SARS-CoV-2 RNA Polymerase Complex by the Cytosolic Chaperonin CCT
PROJECT SUMMARY The COVID-19 pandemic created the greatest infectious threat to global health in 100-years, and monumental efforts have been made by the scientific community to com...
IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain after Surgery
Chronic postsurgical pain (CPSP) is a major healthcare burden, affecting nearly 20% of patients undergoing major surgery.CPSP is associated with diminished quality of life, mood di...
Utilizing Bioprinted Human Stem Cells for Molecular Screening via Multi-Material Strategies
Abstract Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are fundamentally characterized by neuronal damage and cell death. Development of adul...
Cell-cell signaling and pattern formation in yeast
Project Summary / Abstract Pattern formation, the spatial organization of cells of different types, is central to the development and function of metazoans. Pattern formation also...
Microglial TREM2 Mediates Hippocampal Synaptic and Cognitive Sequela of Early Deprivation and Enrichment
PROJECT SUMMARY/ABSTRACT Childhood neglect accounts for 60% of all early life adversities and is associated with profound cortical thinning, hyperactivity, and cognitive deficits t...
Molecular mechanisms of oral deficiencies in Down syndrome
Project summary Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (Hsa21) and is the most common genetic cause of intellectual disability. DS predispose...
Type 2 Diabetes Mellitus and Vascular Contributions to Cognitive Impairment and Dementia (T2DM-VCID)
Project Summary/Abstract A significant gap in understanding is how suboptimal control of hyperglycemia from type 2 diabetes (T2DM) and prediabetes, particularly in young adults (18...
Risk Factors for End-Stage Glenohumeral Osteoarthritis
Project Summary/Abstract Glenohumeral osteoarthritis (OA) can be as debilitating as hip or knee OA, and in the US, shoulder arthroplasty rates for OA are rising more rapidly than h...