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A novel role for EZH2 in PARP regulation and PARPi-resistance in prostate cancer
Prostate cancer is the leading cause of cancer-related deaths in American men. It is estimated that each year more than 180,000 new prostate cancer patients will be diagnosed, and...
Emotion Reactivity, Cognitive Reappraisal, and Suicidal Ideation In Middle-aged and Older Adults at High Suicide Risk
ABSTRACT The goal of this project is to evaluate the temporal and predictive association of emotion reactivity (ER) and cognitive reappraisal (CR) (a well-studied emotion regulatio...
Host-driven antibody responses against Staphylococcus aureus
ABSTRACT Staphylococcus aureus is a human-adapted pathogen that replicates by asymptomatically colonizing its host. S. aureus is also the causative agent of purulent skin and soft...
Defining Heterogeneous Human Mast Cell Effector Function
Project Summary/Abstract: Mast cells (MCs) expand within the epithelium and sub-epithelium during prevalent and burdensome human mucosal disease, including asthma, nasal polyposis,...
Silencer-enhancer transition dysregulates interleukin-6 in mucosal epithelial cell plasticity
PROJECT SUMMARY/ABSTRACT Respiratory viruses, such as Influenza A virus, rhinovirus (RV), respiratory syncytial virus (RSV) and coronavirus, trigger innate inflammation and lung ti...
Hydrogel-Based Aged Immune Organoids to Study Epigenetics and Trajectory of B Cells
PROJECT SUMMARY Aged individuals, who are often at higher risk of fatality in life-threatening infectious diseases, do not form high- quality antibodies against new infections. Hum...
Elucidating resistance mechanisms and enhancing response to immune checkpoint blockade in central nervous system metastases from breast cancer
PROJECT SUMMARY Metastases to the central nervous system (CNS) are a common complication of breast cancer. Prognosis is typically on the order of a few months. Immunotherapies have...
Control and function of repressive chromatin domains
Project Summary/Abstract The long-term goals of this project are to understand the composition, assembly, and function of specialized chromatin domains. Polycomb Group (PcG) protei...
Very Brief Exposure: Exploratory Development of a Novel Exposure Modality for Social Anxiety Disorder in Transition-Age Youth
As one of the most common and impairing disorders among adolescents, Social Anxiety Disorder (SAD) is helping to drive the ongoing mental health crisis in American youth. After the...
Functional and Mechanistic Studies of the Role of Lp17-encoded Factors in Host Adaptation by the Lyme Disease Spirochete
Summary The ability of Borrelia burgdorferi to cause Lyme disease is highly dependent on its capacity to establish a successful infection upon entering the mammalian host. Moreover...
Parents’ Safety Nets, Child Protective Services Involvement, and Child Outcomes
Project Summary/Abstract Child maltreatment is a serious problem in the U.S. and worldwide. An estimated 1 in 7 children are maltreated each year, and most recent annual U.S. data...
Impact of Zika Virus Infection on Fetal Innate and Adaptive Immunity
PROJECT SUMMARY The objective of this proposal is to define the impact of maternal viral infections and inflammation on immune programming within the fetal brain and lymphoid organ...
Multisystem Stress Response Biotypes: Deriving Novel Physiological and Neural Risk Factors for Anhedonia in Adolescence
PROJECT SUMMARY Anhedonia (ANH), the reduced ability to anticipate or experience pleasure, is a major transdiagnostic contributor to disability, inferior quality of life, and a cor...
Investigating Germline Sex Determination
Investigating Germline Sex Determination Establishing sex-specific germ cell identity is critical for development of sperm and eggs and perpetuation of the species. Cells are initi...
Dissecting Histone H3K4 Methylation Enzymes in Neuroplasticity
Abstract One of the long-held mysteries in chromatin signaling is the excessive number of enzymes that install or remove a single chromatin mark. The most extreme case is histone H...
Molecular mechanisms and evolution of natural telomeric variation
PROJECT SUMMARY This proposal will study the plant monkeyflower (Mimulus) to address why telomere lengths vary between individuals, and how that variation affects an organism’s fit...
CRISPR-TB for pediatric TB diagnosis and treatment response
PROJECT SUMMARY/ABSTRACT Children under 5-years of age account for ~50% of the 1.2 million new cases of pediatric TB each year, but are least likely to be diagnosed, and are at hig...
Improving accessibility of virtual interventions for families of infants with neurogenetic conditions - Resubmission
0BPROJECT SUMMARY/ABSTRACT As efforts to identify rare neurogenetic conditions (NGC) earlier in life increase, there is a growing need for accessible, empirically based interventio...
Systems biology to predict progression and treatment response in M avium complex pulmonary disease
PROJECT SUMMARY Prevalence of pulmonary disease due to non-tuberculous mycobacteria in the United States has doubled in the last 10-years, and Mycobacterium avium pulmonary disease...
Phenotypes REimagined to Define Clinical Treatment and Outcome Research (PREDiCTOR)
PROJECT SUMMARY Psychiatry faces a significant challenge in the absence of objective measures to assess behavior. Clinicians form clinical opinions based largely on their impressio...