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99,167 grants found
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Deciphering the Thalamic Reticular Functions of Phospholamban
PROJECT SUMMARY The thalamic reticular nucleus (TRN) is a poorly understood structure of the mammalian forebrain that is deeply involved in regulating complex behaviors such as sen...
Cholinergic interneuron regulation of opioid-related behaviors
Project Summary Opioid use disorder (OUD) is a debilitating and life-long addictive disease with significant public health costs. OUD is characterized by various symptoms, includin...
Kidney Disease Aging Research Collaborative (KDARC) Research Infrastructure to Advance the Science of Geriatric Nephrology
ABSTRACT Kidney Disease Aging Research Collaborative (KDARC) will address a fundamental challenge in nephrology by establishing infrastructure to support sustainable interdisciplin...
Molecular Dissection of Alcohol Use Disorder Through Targeted Brain Multi-omics
PROJECT SUMMARY This proposal brings together experts in the genomics of neuropsychiatric disorders and translational neuroscience to investigate the molecular pathology of alcohol...
Cross-species conservation of inhibitory cell type contributions to visual cortical function
Project Summary The function of the nervous system is dependent on complex interactions between networks of neurons composed of multiple neuron types. Understanding how these netwo...
MAEVE: Microbiota mediated flavonoid metabolites for cognitive health
ABSTRACT Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimer's disease (AD). The lack of effec...
Short Sleep Duration as a Predictor of Methamphetamine Intake: Role of Orexin Mechanisms
Project Summary_________________________________________________________________________ Insufficient sleep predicts substance use and associated psychosocial problems, and puts in...
Using behavioral economic domains to characterize cannabis use trajectories among young adults: A prospective mixed-methods investigation
PROJECT SUMMARY Young adulthood (ages 18-25) is a critical developmental period during which individuals often escalate or mature out of substance use. Indeed, young adults (YA) us...
Multifaceted Characterization of Early Human Brain Development
Multifaceted Characterization of Early Human Brain Development Abstract In the first few years of life, the human brain develops dynamically in both structure and function. Many ne...
Sleep Variability and Cardiometabolic Health Among Women
Project Summary Cardiovascular disease (CVD) mortality has declined significantly over the past two decades, but there has been a recent rise in CVD deaths among younger women (age...
Geriatric assessment domains in relation to treatment outcomes among older adults with colorectal cancer
PROJECT ABSTRACT. About 75% of the newly diagnosed colorectal cancer patients are ≥70-years old and have the lowest 5-year relative survival (61%) due to comorbidity and frailty. C...
NOTCH3 ECD as a Serum Biomarker for Pulmonary Arterial Hypertension
PROJECT SUMMARY/ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive and incurable disease involving pathological signaling between pulmonary arterial smooth muscle cell...
ACCESS: Advancing Contraceptive Equity and Service Uptake through Telemedicine in the US Safety-Net, 2019-2025
PROJECT SUMMARY ACCESS: Advancing Contraceptive Equity and Service Uptake through Telemedicine in the US Safety-Net, 2019-2025 Unintended pregnancy is a key indicator of health ine...
Mitochondrial DNA in extracellular vesicles for early detection and recurrence prediction in triple negative breast cancer racial disparity
PROJECT SUMMARY Highly recurrent and metastatic triple-negative breast cancer (TNBC) is predominant among young African American (AA) compared to European American (EA) women. Alth...
Population-Based Assessment of the Health Effects of Climate Exposure Using Hyperlocal Predictive Models
` Project Summary We aim to develop a daily temperature model on 30m road segments for all roads in the contiguous United States from 2000 to 2020. We will use satellite data, land...
Kidney transplant Preemptive therapy or Prophylaxis (KPoP) for CMV Preventionin D+R- Recipients
In kidney transplant recipients (KTR), cytomegalovirus (CMV) increases short- and long-term morbidity, mortality, and allograft failure, mainly due to limitations in current preven...
Cross talk between keratinocytes and skin-resident T-cells influences HSV recurrence
PROJECT SUMMARY/ABSTRACT Keratinocytes, the major building block of skin epidermis, are the primary target of herpes simplex virus (HSV) infection as well as the mediator of local...
Death of a loved one: Prevalence, risk, and protective factors for prolonged grief disorder
Bereavement is highly prevalent among older adults, a rapidly growing demographic of the US population that is projected to double by 2050. Estimates suggest that 3%- 10% of bereav...
Circulating tumor cell profiling for genomic contributors to racial disparity in metastatic prostate cancer
PROJECT SUMMARY/ABSTRACT In the United States, prostate cancer is the most prevalent malignancy, with disproportionately higher incidence and mortality rates among black men than t...
Linking mania/hypomania with abnormal reward expectancy- and approach-related neural network activity and dopamine release
ABSTRACT. Mania/hypomania, the defining symptom of Bipolar Disorder (BD), is extremely disabling, leading to significantly impaired health and psychosocial function. Yet, current t...