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99,167 grants found
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Scalable multi-ancestry functional genomics of blood traits and cardiovascular disease
PROJECT SUMMARY Cardiovascular disease (CVD) is the most common cause of mortality in the world. Genome-wide association studies (GWAS) have successfully identified numerous geneti...
Reparative functions of human airspace macrophage subsets
PROJECT SUMMARY For lung health to be restored after inflammation, dead cells must be removed from the airspaces and the alveolar epithelium must be repaired. Airspace macrophages...
Investigating Pathways from Adverse Pregnancy Outcomes to Alzheimer's Disease and Related Dementias: the nuMoM2b-Brain Study
PROJECT SUMMARY/ABSTRACT Placentally-mediated adverse pregnancy outcomes (APO), including hypertensive disorders of pregnancy, preterm birth, and fetal growth restriction, may play...
Targeting age-related endosome dysfunction to treat cognitive decline and Alzheimer's disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with a growing humanitarian and economic burden. Advanced age is the greatest risk factor for AD so the long- te...
Adipocyte cytokine signaling as a coordinator of adipose tissue function
Adipose tissue inflammation directly contributes to the overall inflammatory state in obesity, with immune cells being intimately involved regulating adipocyte function and vice ve...
Multimodal Characterization of Cerebral Reorganization in Children with Unilateral Cerebral Palsy
PROJECT SUMMARY Cerebral palsy is the most common pediatric movement disorder and is caused by damage to brain areas during development. Children with unilateral cerebral palsy (UC...
Advanced multiplexing technologies with innovative Dual-Channel Dark-FRET biosensors for dynamic monitoring of alpha-synuclein pathophysiology: From cellular to in vivo models
ABSTRACT: Alpha-synuclein (aSyn) accumulation and misfolding is implicated in the pathogenesis of Parkinson's Disease (PD) and related synucleinopathies. These disorders inclu...
tRNA-derived short and long RNAs in aging
ABSTRACT Some of the most novel insights in aging have come from studies in model organisms like S. cerevisiae. While a lot has been done about gene (mRNA) expression changes that...
Targeting FGFR Alterations in Gastroesophageal Cancer
PROJECT SUMMARY Gastroesophageal adenocarcinoma (GEA) is the 4th leading cause of cancer deaths worldwide with a median survival of 6.2 months for patients who present with metasta...
Cellular and Molecular Mechanisms Underlying Merkel Cell Loss and Regeneration
Summary The mechanosensory Merkel cells (MCs) are crucial for encoding the sense of light touch. Recent studies have shown that MCs also significantly regulate alloknesis, the itch...
Microbial regulation of intestinal epithelial gene expression
Abstract The intestinal epithelium serves essential functions of dietary nutrient absorption and defense against microbial infections through the coordinated regulation of gene exp...
Dual p300 and p53 reactivation in HPV+ head and neck cancer
Project Summary Incidence of HPV+ OPC has been increasing for several decades and this upward trend is expected to continue until at least 2060. Current first-line modalities to ma...
Effect of obesity and diabetes in regulating pulmonary and extra-pulmonary anti-viral immune responses
ABSTRACT: Diabetes, particularly type 2 diabetes (T2D), is associated with hyperglycemia (Hg) and obesity (Ob). Hg/Ob is associated with greater severity of disease and mortality i...
Mechanisms of epithelial-mesenchymal crosstalk in intrahepatic biliary formation
Project summary Currently, there is no cure for intrahepatic bile duct (IHBD) paucity except for liver transplantation. IHBD paucity causes accumulation of pathologic bile within t...
Patch-based deep scRNA-Seq to understand axon repair in the mammalian spinal cord
PROJECT SUMMARY / ABSTRACT Traumatic spinal cord injury is a devastating condition that affect about 302,000 people in the United States, with 18,000 new cases each year. The limit...
X chromosome dosage compensation and the regulation of the feto-maternal interface
PROJECT SUMMARY The goal of this proposal is to investigate how gene expression dosage on the X chromosomes is regulated during embryonic and extraembryonic development and how its...
Lymphatic drainage dysfunction in chronic hypertension
Abstract Malfunction of the brain’s waste clearing glymphatic system has been shown to play a key role in cerebral small vessel disease the most common cause of vascular cognitive...
ATG16L1 isoforms and CRC health disparities
Compared to non-Hispanic Whites (NHW), African Americans (AAs) are 20% more likely to get colorectal cancer (CRC) and 40% more likely to die from CRC. The negative impacts of healt...
Surgeons as High-Performance Athletes: Applying Player Development Strategies from Professional Sport to Enhance Surgical Performance
General thoracic and adult cardiac (“cardiothoracic”) surgical procedures are among the most frequently performed high-risk inpatient procedures. Despite technological advances and...
Developing single nuclei tRNA-seq to profile tRNA diversity at the single cell level
Project Summary/Abstract Transfer RNA (tRNA) biogenesis is essential for determining the pool of tRNAs that set the translational state of cells, and defects in the tRNA biogenesis...