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99,167 grants found
Showing 4,701 – 4,720 of 99,167 grants
Investigating the mechanistic consequences of fentanyl-induced hypoxia and cardiorespiratory collapse
PROJECT SUMMARY Acute exposure to ultrapotent synthetic opioids (UPSO), such as fentanyl, represents a significant public health concern. In the ongoing opioid epidemic, it is esti...
Influence of MHC-II polymorphisms on autoimmune T cell repertoire development and function
Abstract Type 1 diabetes (T1D) results from immune-mediated destruction of islet beta cells within the pancreas, which leads to the inability of the body to produce insulin, dysreg...
Defining the role of Tox3 in congenital cerebellar hypoplasia and ataxia
PROJECT SUMMARY / ABSTRACT The cerebellum is an exquisitely laminated structure regulating balance, voluntary motor coordination and modulating language and cognition through conne...
Chromatin regulation of BDNF in cocaine craving
SUMMARY Cocaine addiction is driven by drug-induced adaptations in the function of mesolimbocortical brain reward circuits. A major unanswered question in the field of addiction bi...
Investigating the function of bacterial cytoskeletal elements in the division and growth of the FtsZ-less Chlamydia
Project Abstract: Investigating the Function of Bacterial Cytoskeletal Elements in the Division and Growth of the FtsZ-less Chlamydia Chlamydia is an obligate intracellular bacteri...
Mechanisms of Cell-type-specific pre-mRNA Splicing
Mechanisms of Cell-type-specific pre-mRNA Splicing Abstract: The overarching goal of this project is to uncover cis- and trans-regulatory mechanisms of pre-mRNA splicing at the cel...
The Role of Gab2-MALT1-mediated cell signaling in venous thrombogenesis
Venous thromboembolism (VTE), which comprises deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cause of vascular death after a heart attack and stro...
Connexin 43: a new player in Duchenne muscular dystrophy associated cardiomyopathy
SUMMARY Duchenne muscular dystrophy (DMD) is incurable. Lack of dystrophin is the culprit. While the ultimate solution to this devastating disease is to restore dystrophin, the sci...
Definitive Evaluation of Gastric Dysrhythmia as a Disease Mechanism by a Novel Body Surface Gastric Mapping Technique
Functional dyspepsia and chronic nausea and vomiting syndromes affect >10% of the population, inducing a vast burden of ill-health and economic harm. Yet despite their enormous...
Optimizing Aerobic Fitness and Functional Response to Exercise in Older Adults.
PROJECT SUMMARY Clinical events and hospitalization can be physically disabling, especially for older adults because of their reduced physiological reserve. Cardiovascular disease...
STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners
PROJECT SUMMARY This NIH Stage 1B study (9) will advance development of an intervention, STELLA-FTD (Support via Technology: Living and Learning with Advancing FTD), that is design...
Dissolved Phase Hyperpolarized Xenon-129 MRI: a novel biomarker to quantify pulmonary pathology in young healthy e-cigarette users
Project Summary Over the past ten years, electronic cigarettes (e-cigarettes) have been commercialized as a “less harmful” alternative to traditional cigarettes. Preclinical models...
Targeting Residual ASCVD Risk by Integrating Genetics and Clinical Data
Patients regularly have myocardial infarctions or strokes, despite being on treatment to lower low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP). This residual ri...
The impact of aging on neutrophil-mediated protection and inflammation in the female genital mucosa
PROJECT SUMMARY Urogenital infections, including sexually transmitted infections and other genitourinary tract infections, are a major source of morbidity and mortality in older wo...
Dissecting the neural circuit mechanisms that generate dopamine neuron activity
Project Summary The midbrain dopamine system plays a crucial role in various brain functions such as learning, motivation, and movement, and its dysregulation has been linked to va...
Improving Perioperative Care for Patients with Opioid Tolerance
In the United States, nearly 1 in 6 adults filled an opioid prescription in the past year and 10 million adults are opioid tolerant. Compared with opioid naïve patients, individual...
Post-translational regulation of hepatic uptake transporters in health and disease
PROJECT SUMMARY Given the growing prevalence of metabolic syndrome, obesity, and nonalcoholic fatty liver disease (NAFLD), we need to know how these disease states affect the funct...
Substrate-mediated collective cell migration incalvarial bone expansion and disease.
Summary Congenital defects affecting the formation of the skull roof, such as craniosynostosis or persistent fontanelles, occur as a result of abnormal calvarial growth and differe...
Unmasking the role of maternal transcript UTRs in reproductive fecundity
Project Summary: My lab is interested in defining how the maternal load is established during oogenesis and decoded af- ter fertilization. We know the identity of the most importan...
Antisocial Behavior in Frontotemporal Dementia: Behavioral Phenotypes, Neural Markers, and Decision-Making Mechanisms
Project Summary: Antisocial behaviors like lying, stealing, reactive aggression, and sexually inappropriate behaviors are common in behavioral variant frontotemporal dementia (bvFT...