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Characterizing Intersectional Geospatial Stigma and Affirmation Landscapes and Their Influence on Black and Latino Bisexual Men At Risk for Substance Abuse and HIV
PROJECT SUMMARY Guided by Fundamental Cause Theory with innovative methodologies, this proposal examines the impact of geospatial intersectional stigma and affirmation on substance...
Towards a harm reduction approach to perinatal cannabis use
PROJECT SUMMARY/ABSTRACT In the United States (US), it is recommended to not use cannabis during pregnancy or while breastfeeding (referred to as “perinatal cannabis use”) because...
Tailoring Diabetes Support to Social Contexts for Adults Living with Type 2 Diabetes
PROJECT SUMMARY Among adults with type 2 diabetes (T2D), daily diabetes self-management occurs in social contexts with close family and friends (herein, “family”). We recently deve...
Role of Frontal Cortex in Self-Control
Project Summary Behavioral control is a fundamental component of executive control and requires the ability to suppress actions, thoughts, and desires. Deficits in behavioral contr...
Regulation and maintenance of thiyl radicals in enzyme catalysis and protein degradation
Project Summary Thiyl radicals lie at a perilous nexus between essential biological function as cofactors in enzyme catalysis and toxic products of oxidative stress. As a cofactor,...
Transcriptional regulation of Myelopoiesis
Abstract Myeloid cells are amongst the first responders to pathogenic insults, but there remains a substantial knowledge gap concerning mechanisms that control their development in...
Pharmacomicrobiomics: The Frontier of Interindividual Variability in Drug Response
PROJECT SUMMARY Many medications for diverse indications are modified by intestinal bacteria, positioning them as an emerging and significant driver of overall drug response (effic...
Advancing Community Connections and Calculating Risk to Optimize Stroke Survivorship (ACROSS)
The risk and burden of stroke are disparately experienced by racially and ethnically minoritized populations and socioeconomically disadvantaged groups; these disparities are subst...
Structural and functional investigations of bacterial fibrillar adhesins
PROJECT SUMMARY The ability of bacteria to adhere to each other and both biotic and abiotic surfaces is key to their ability to cause infection and persist in the environment. Bact...
Combating Chronic Liver Diseases via Understanding and Engineering Cell Competition and Fitness
Summary: Cell competition removes mutated cells and enables robust tissue development, eliminates oncogenic cells in adulthood, as well as damaged cells during aging. We identified...
Translation Fidelity in Hematopoietic Stem Cell Aging and Longevity
ABSTRACT Hematopoietic stem cells (HSCs) regenerate blood and immune cells throughout life. However, aging HSCs exhibit reduced self-renewal activity, diminished regenerative capac...
Interrogating the relationship between translational dynamics and non-canonical antigen presentation in lung cancer
ABSTRACT Antigen presentation is a fundamental component of cancer immunity. The primary cytotoxic effectors of cancer immunity are CD8+ T cells, which recognize peptide antigens p...
Gene Therapy for ALPK3 Cardiomyopathy Using MiniALPK3
PROJECT SUMMARY Alpha Protein Kinase 3 (ALPK3) is an atypical protein kinase belonging to the alpha (α)-kinase family. Loss-of- function mutations in ALPK3 result in human cardiomy...
Beyond discovery: bat behavior and virus shedding as drivers of spillover risk
PROJECT SUMMARY The COVID-19 pandemic has reinforced the significance of emerging infectious diseases for human health and security. Bats have been associated with high-profile vir...
Nutrient-driven bacterial physiology in recalcitrant infections.
Project Summary We currently lack effective therapies for treating chronic infections because most antibiotics were screened for their ability to kill fast-growing, planktonic bact...
Mechanosensing in lung fibrosis
Project Summary Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease that results in lung scarring and breathing difficulty with a median survival of 2-5-years fol...
Epidemiologic study of microplastic pollution in bronchoalveolar lavage fluid and its association with lung cancer
ABSTRACT An estimated 400 metric tons of plastic are produced each year worldwide and less than 10% is recycled. Microplastics (MPs) defined as particles
Defining the Quantitative Functional Mechanisms that Underly Gut Microbiome-Diet Interactions Contributing to Human Energy Balance
Project Summary The obesity epidemic continues to afflict populations globally. The literature is replete with observational studies purporting a role of the gut microbiome in body...
Non-conventional signaling by α5 integrin in blood and endothelial cells
SUMMARY – Integrins interact with their ligands to induce intracellular signals that mediate cellular activities such as cell adhesion, spreading, and migration, which are the esse...
WASp signaling in T-cell lymphomas
ABSTRACT Title: WASp signaling in T-cell lymphomas Peripheral T-cell lymphomas (PTCL) are aggressive disorders, with less than 50% overall survival after 2-3-years of diagnosis. Th...