Browse All Grants
99,167 grants found
Showing 4,661 – 4,680 of 99,167 grants
Extensive drug histories result in compulsive appetite: functional identification of punishment-reactive neural network re-organization in the rostromedial tegmental nucleus
PROJECT SUMMARY Binge-eating disorder (BED) and bulimia nervosa (BN) are potentially life-threatening eating disorders that share behavioral and brain similarities, genetic risk fa...
The Functional Role of Dusp4 in Skeletal Muscle
PROJECT SUMMARY/ABSTRACT Skeletal muscle shows amazing plasticity and has the capacity to continuously regulate its size in response to external cues such as mechanical load, neura...
Immune control by GBPL proteins in Arabidopsis
Project Summary Every living organism possesses a defense system crucial for distinguishing self from potentially harmful foreign invaders. This defense system is essential for sur...
Inferring causality with spatiotemporally stochastic optogenetics
Project Summary Different cognitive behaviors appear to engage distinct activity patters across brain-wide circuits. This distributed nature poses a big challenge to understanding...
Mechanistic Insights into Single-Strand Break Repair Within Chromatin
Project Summary With cells constantly encountering DNA damaging agents, mechanisms for prompt DNA repair are crucial for maintaining genomic stability. Aberrations and mutations in...
VOLTAGE-SENSING MECHANISMS OF ION CHANNELS IN DYNAMIC LIPID MEMBRANES
PROJECT SUMMARY/ABSTRACT Ion channels in the voltage-gated ion channel (VGIC) superfamily play pivotal roles in virtually all physiological processes. This proposal delves into ess...
Using Novel Labeling to Improve Public Understanding of Nicotine in Electronic Nicotine Delivery Systems (ENDS): Nicotine Concentration and Nicotine Flux
Project Summary Use of Electronic Nicotine Delivery Systems (ENDS) can have positive and negative effects on public health. Ideally, people who smoke would switch to ENDS, and vuln...
Brainstem mechanisms of opioid-induced respiratory depression
Project Summary Opioid overdoses continue to rise at an alarming rate in the US. Respiratory failure is the cause of death from opioid overdose. Yet, the mechanisms by which respir...
Molecular regulation of β2 integrin activation in neutrophil adhesion and inflammation
Abstract Cardiovascular disease (CVD) kills one in four of the people who die annually in the United States and is a major disease burden worldwide. Inflammation is the main underl...
Molecular mechanisms of Eph receptor signaling
PROJECT SUMMARY The survival of every multicellular organism relies on effective cell-cell communication. Despite the diversity of signals that cells need to communicate to their n...
Effects of polyamines on chromatin function
PROJECT SUMMARY The traditional view of cellular metabolism is that metabolic reactions exist to maximize catabolic (energy generation) or anabolic (growth) states. Over the past d...
Towards the Design of Programmable, Isoform-Selective Proteome Editing System
Abstract The proposed work in this MIRA application focuses on my long-term goal to create programmable toolkits for proteome editing. Inspired by research into developing broad-ta...
Cellular and Behavioral Function of Astrocytic Dopamine Signaling
Abstract It has long been known that that astrocytes in the nucleus accumbens (NAc) and other motivation-regulatory brain regions express dopamine receptors, but the cellular and b...
Biophysics and Cell Biology of Meso-scale Gap Closure
PROJECT SUMMARY Background: Gap closure is a critical step in wound healing and the maintenance of tissue homeostasis during embryogenesis. Current studies of gap closure focus on...
Improving sepsis care with AI-based clinical decision support
Project Summary Sepsis is a syndrome characterizied by a dysregulated host immune response to an infection that leads to organ dysfunction. Because sepsis is among the leading caus...
Development and Applications of Reactions to Enable Molecular Rigidification
PROJECT SUMMARY Rigidity is an important property of molecules that increases the likelihood of their success as drugs. Our goal with support of this MIRA grant is to develop react...
Expanding the chemical probe development paradigm toward underexplored targets
SUMMARY/ABSTRACT Despite advances in high-throughput screening technologies, initial hits require extensive optimization by medicinal chemistry to yield molecules with the potency...
Role of Liver Kinase B1 in the decreased angiogenesis in bronchopulmonary dysplasia
PROJECT SUMMARY Bronchopulmonary dysplasia (BPD) is the most common complication of premature birth and increases the risk of mortality, long-term medical needs, and neuro-developm...
Characterizing the effect of transcription-replication conflicts on transcription and co-transcriptional processes
PROJECT SUMMARY Coordination between the replication and transcription process is one of the major challenges that cells face duringproliferation. As both replication and transcrip...
Employment Insecurity and Substance Use in U.S. Adults
PROJECT SUMMARY Employment insecurity (EI; unemployment or underemployment) may escalate substance use as a maladaptive coping mechanism for distress. The COVID-19 pandemic trigger...