Browse All Grants
99,167 grants found
Showing 4,641 – 4,660 of 99,167 grants
Investigating the bidirectional relationship between circadian rhythms and cannabinoid use
PROJECT SUMMARY/ABSTRACT Cannabis use is on an upward trajectory due to recent decriminalization and legalization. This increased use is associated with numerous health and behavio...
Novel roles for the circadian transcription factor NPAS2 and striatal dopamine D3 receptor signaling in diurnal fentanyl craving and relapse
PROJECT SUMMARY Our proposal is in direct response to NIDA RFA-DA-24-020, “Mechanistic Studies to Investigate the Interrelationship between Sleep and/or Circadian Rhythms and Subst...
Synaptic Resilience to Tau in Alzheimer's Disease
Project Summary Approximately one-third of individuals without dementia at the time of death are found to harbor high levels of Alzheimer’s disease (AD) pathology, including amyloi...
Intersection of GBA and LRRK2 in Lewy Body Dementia
Lewy body dementia (LBD) is the second most common form of neurodegenerative dementia, behind only Alzheimer’s disease (AD). LBD is clinically defined as a dementia that arises pri...
Selective vulnerability and resilience to trans-synaptic pathological tau spreading in Alzheimers disease
PROJECT SUMMARY The incidence of Alzheimer’s disease (AD) is on the rise, and we are in dire need of effective treatments. In AD, the spatiotemporal progression of tau pathology wi...
Cardiac Exosomes in myocardial Ischemic injury
PROJECT SUMMARY / ABSTRACT Ischemic heart disease, the leading cause of mortality worldwide and at $475 billion/year also the costliest disease in the US, is highly heritable. Isch...
Endothelial extracellular vesicles in aging
Project Summary The aging population is rapidly growing. Aging is associated with impaired organ function and repair and increased susceptibility to various chronic diseases. Angio...
Molecularly Dissecting How Obesity-Promoting Diets Activate the Neuronal Protein Aggregation Factor MOAG-4/SERF2
Abstract Obesity is an independent risk factor for Alzheimer's disease (AD). With obesity prevalence at 37% and rising, the urgency to uncouple obesity from AD is pressing. Un...
Orexin (hypocretin) signaling in ventral tegmental area as a common mediator of sleep disturbances and drug demand in cocaine abstinence
Summary/Abstract: Initial cocaine abstinence is associated with severe sleep disturbances. Poor sleep is one of the strongest predictors of return to use (relapse), suggesting pote...
Mechanistic studies of opiate withdrawal-induced sleep disturbances
PROJECT SUMMARY The majority of patients with Opioid Use Disorder (OUD) report sleep problems such as insomnia. Sleep disruption commonly occurs during opiate withdrawal and has be...
Formative work for the development of an intervention to support combined HIV/syphilis self-testing and linkage to prevention and treatment services for transgender women in South Africa
ABSTRACT In South Africa (SA), the country with the world's largest HIV epidemic, ~45.6% of transgender women (TW) may be living with HIV. Of these, estimates show that 1/3 ar...
Epigenetic profiling of HIV-associated neuroinflammation and proviral expression in the brain
Abstract Background: HIV infection in the brain occurs early after transmission and leads to chronic neuroinflammation. Although modern antiretroviral therapy (ART) controls viral...
Optimizing a Just-in-Time Adaptive Intervention to Increase Uptake of Chemsex Harm Reduction Services in MSM: A Micro-randomized Trial
ABSTRACT Chemsex, the use of psychoactive drugs before or during sexual activity, is a growing public health concern due to its association with increased HIV transmission and othe...
Role of mitochondrial/ER contacts in the regulation of mtDNA release from mitochondria, innate immune signaling, and responses to viral infection
PROJECT SUMMARY Innate immunity is critical for human health, allowing cells to detect and combat invasion by pathogens. Mitochondria are essential organelles that play important r...
Modeling biotic and environmental drivers of seasonal West Nile virus transmission
West Nile virus (WNV) is the most prevalent arbovirus in the US and seriously threatens the health of livestock, wildlife (especially birds) and humans. WNV transmission shows clea...
Defining the role of Sf1 in urethral closure
Hypospadias is one of the most common birth defects in the world affecting nearly 1% of newborn boys. Hypospadias is the result of disrupted urethral closure where the urethra exit...
Impact of SARS-CoV-2 on the cerebrovasculature as a risk factor for VCID: Role of Wnt/beta-catenin
Abstract COVID-19 increases the risk of vascular contributions to cognitive impairment and dementia (VCID). VCID is one of the most prevalent forms of dementia, so the potential pu...
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Project Summary This K99/R00 application proposes a comprehensive career development plan and a series of investigations, coupled with an outstanding mentoring committee specifical...
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cells
PROJECT SUMMARY/ABSTRACT Carbon monoxide (CO) inhalation is a leading cause of human poisoning in the United States, resulting in about 50,000 cases and at least 1,500 deaths annua...
Neuroimmune axis contribution to the pathophysiology of pulmonary hypertension
PROJECT SUMMARY/ABSTRACT Pulmonary hypertension (PH) is a progressive disease leading to right heart failure and an unacceptably high mortality rate. Despite major milestones in ou...