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Air Pollution-Derived Iron Exposure, Poverty-Related Stress, and Alzheimer's Disease Risk
A hallmark of Alzheimer’s Disease (AD) is regional brain “iron (Fe) overload”. We hypothesize that life- long exposure to inhaled Fe via air pollution (AP) is a contributor to elev...
Musculoskeletal Adaptive Platform Trial (MAPT)
ABSTRACT Over 1 million Americans undergo surgical treatment for a fracture each year. Despite advances in clinical research over the past few decades, poor outcomes remain unaccep...
Induction, fate and function of inflammatory fibroblasts
PROJECT SUMMARY By single cell RNA sequencing we have identified multiple molecular states of fibroblasts that emerge from normal alveolar fibroblasts in response to fibrogenic sti...
Interrogating infant immune responses for diagnosis of congenital syphilis infection
ABSTRACT Syphilis infection remains endemic among adults worldwide. Rates are rising among women of childbearing age in the U.S., resulting in a concomitant increase in congenital...
Optimizing PepTAC structure and amphiphilicity for enhanced target protein degradation
Project Summary This study seeks to advance heterobifunctional degraders that induce targeted protein degradation through the ubiquitin proteasome pathway. Typically, molecular deg...
Mechanisms of Anabolic Resistance in Older Humans
Our preliminary data suggest that inflamed adipose tissue may contribute to blunted exercise response in skeletal muscle of older adults. The objective of this project is to evalua...
Translating glycans into biomarkers
Alterations in glycosylation have been associated with the development and progression of many types of cancers and other chronic and acute diseases. Structural glycan analysis on...
Deep Learning Methods for Improving Gallium 68-Based PET Imaging
Abstract Neuroendocrine tumors (NETs) are a heterogeneous group of tumors with increasing incidence, which are hard to identify in the early stage and repeatedly misdiagnosed, yiel...
Molecular Profiling and Biomarkers of Memory Phenotypes in Temporal Lobe Epilepsy
PROJECT SUMMARY Temporal lobe epilepsy (TLE) is a leading cause of seizure disorders in adults and is associated with high risk of memory deficits that can negatively impact day-to...
Intracellular Collagen Sensing in Pulmonary Fibrosis
PROJECT SUMMARY Despite decades of research, the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) is still not completely understood. As a consequence, IPF causes significant mo...
PET/CT Imaging of Venous Thromboembolism in Pediatric, Adolescent, and Young Adult Oncology
PROJECT SUMMARY The long-term goal of this work is to develop a non-invasive imaging strategy for quantifying chemotherapy- induced vascular toxicity to better understand the poten...
Structure and Function of a Pentameric TRPV3 Channel
Abstract Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily that control diverse physiological functions, and are therefore attractive drug...
Preventing Drug Use Onset and Progression toward Addiction during a CriticalTransition Period: Optimizing an Online Intervention for High School Seniors
PROJECT SUMMARY/ABSTRACT The overall objective of the proposed research is to optimize a readily scalable online behavioral intervention that will prevent and reduce substance use...
Investigating mechanisms of tumor plasticity in human bladder cancer
Project Summary/Abstract The progression of bladder cancer from non-invasive to muscle invasive disease represents a critical step that is associated with adverse clinical outcomes...
Functional Mapping of Chd1-dependent Signaling Network in Synaptic Homeostasis
Abstract Autism Spectrum Disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by significant developmental, intellectual, and behavioral impairments. Pati...
Pediatric POTS: does a periaqueductal gray-vagus nerve interface malfunction explain the natural history with its numerous co-morbidities ?
PROJECT SUMMARY / ABSTRACT Postural tachycardia syndrome (POTS) is a common, disabling disorder among adolescents, interfering with their schoolwork, physical and social developmen...
Fungal-bacterial dynamics driving dysregulated host responses and lethal synergism
Polymicrobial infections involving fungal and bacterial pathogens are increasingly common among hospitalized patients. However, there is a paucity of research focused on studying p...
Cell senescence in aging fracture
Project Summary/Abstract Bone fractures in the elderly are a serious health issue due to high morbidity and mortality. New therapies are needed to reduce treatment time and decreas...
Molecular and Cellular Mechanisms of Cerebellar Dysfunction in Neurodevelopmental disorders
PROJECT SUMMARY Neurodevelopmental disorders (NDDs) encompass a broad constellation of highly prevalent and etiologically heterogeneous disorders that share several key diagnostic...
Hormetic regulation of autophagy in aging
PROJECT SUMMARY Autophagy degrades cytosolic material, such as aggregated proteins, via the formation of autophagosomes that fuse with lysosomes for degradation and is important in...