Browse All Grants
99,167 grants found
Showing 4,601 – 4,620 of 99,167 grants
Directly Converted Neurons as a Novel Cellular Model for ALS and FTD
Modeling human adult-onset neurodegenerative diseases has been historically difficult, with current induced pluripotent stem cell (iPSC) models often showing mild phenotypes. While...
Growing Xylazine Supply in NC: A Community-Based Investigation of Exposure and Health Consequences
PROJECT SUMMARY/ABSTRACT We propose a community-based, longitudinal, mixed-methods study to investigate the growing crisis of xylazine exposure among people who use drugs (PWUD) in...
Engineered GABA oxidase for GABA sensing in vivo
Project Summary The goal of this project is to engineer a g-aminobutyric acid (GABA) oxidase suitable for the creation of a high- performance, implantable, electroenzymatic GABA mi...
Vitamin D and Gut Microbiota and Dementia Risk in Older Adults with Chronic HIV infection and Demographically Matched Community Controls
The global burden of Alzheimer’s dementia and related disorders (ADRD) is growing in tandem with the demographic transition toward an aged society where older adults ≥65-years old...
Molecular Mechanisms regulating Primordial Follicle Formation
PROJECT SUMMARY/ABSTRACT Despite its importance to the continuation of species, the differentiation of primordial germ cells into functional oocytes is poorly understood. Primordia...
Next generation metabolic imaging of the effect of exercise on mitochondrial function in Alzheimer's disease
Project Summary/Abstract While heart disease remains as the leading cause of death in the United States, an estimated 6.7 million Americans aged 65 and older are living with Alzhei...
Investigating Neuroenergetic Changes through Diet in Aging and Alzheimer’s Disease (INC-AD)
PROJECT SUMMARY Impaired brain energy metabolism is increasingly recognized as an important target mechanism for Alzheimer’s disease (AD) prevention and treatment. Increasing evide...
An Analysis Of The Multi-Level Factors That Impact Provision Of Emergency Medical Services To Hispanic Older Adults
Project Summary/AbstractHispanics are one of the fastest growing populations of older adults in the United States (U.S.). From 2019 to 2060, thepopulation of Hispanic older adults...
Role of LGR+ connective tissue progenitors in TMJ development
PROJECT SUMMARY According to NIDCR, temporomandibular joint (TMJ) disorders affect up to 12% of the population and are a major priority for further research. The high incidence in...
Computational tools for precision genome editing
PROJECT SUMMARY This project proposes to develop and refine computational tools to advance the safety and efficacy of genome editing, addressing the critical need for precise quant...
Site-randomized Trial of a Novel Social Network Recruitment Intervention to Locate More Undiagnosed Positive Cases of HIV, Increase HIV Testing among Men, and Reduce HIV-related Stigma in South Africa
PROJECT SUMMARY/ABSTRACT In South Africa's large generalized HIV epidemic, male-to-female transmission comprises a large proportion of transmission events, but men are much le...
Vaccine immunity and inflammation in the aging person living with HIV
Persons living with HIV (PLWH) are at increased risk of chronic inflammation and the associated adverse health outcomes. There is considerable evidence that chronic inflammatory co...
Addressing Perinatal Depression and PMTCT Adherence in Malawi: A Couple-based Approach
Project Summary/Abstract Prevention of mother-to-child transmission (PMTCT) of HIV virtually eliminates transmission of HIV from mothers to their infants. However, adherence to PMT...
Registration Development Program for LUCEMYRA (Lofexidine) Label Expansion for Opioid Withdrawal Treatment in Adolescents
PROJECT SUMMARY: An alarming increase in the rate of opioid abuse among the general population has resulted in a public health emergency since 2017. The striking rise in opioid use...
Ketogenic Diet in Weight Recovered Anorexia Nervosa to Target Metabolism and Normalize Persistent Eating Disorder Psychopathology
Project Summary Anorexia nervosa (AN) is a severe psychiatric disorder. However, we lack neurobiological models and interventions to explain and treat the core characteristics of f...
From Gut to Blood: Dissecting the mechanisms of CD4+ T cell pathology in islet autoimmunity across tissue environments.
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Type 1 diabetes (T1D) is an autoimmune disease t...
Novel pseudo-differential methods to drastically increase computational speed and accuracy for biomedical ultrasound imaging and focusing
Project Summary / Abstract The practical contribution of computational mathematics to ultrasound-based biomedical applications hinges on the efficiency and accuracy of algorithms t...
Genetic predisposition and misdiagnosis of cancer in All of Us participants
SUMMARY/ABSTRACT The National Cancer Institute estimates ~40% of persons in the United States will be diagnosed with cancer at some point in their lives (https://www.cancer.gov). W...
Clonal expansion: a marker of disease activity in stage 1 T1D
SUMMARY Type 1 Diabetes (T1D) is an immune mediated disease in which immune cells destroy insulin producing beta cells of the pancreas. Yet, T1D pathogenesis starts even before dam...
Race/ethnicity and Environmental Stressors: POtential drivers of Dementia and stroke inequities RESPOnD
Excess risk for Alzheimer’s disease-related dementias (ADRD) persists among older Black and Latino adults. ADRD prevention research has focused on individual vascular risk factors,...