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99,167 grants found
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Efficacy and signaling modulation by targeting the sodium site at mu opioid receptor
ABSTRACT Opioids until recently were the drugs of choice to treat moderate to severe chronic pain. Decades of intensive research has led to the pharmacological characterization of...
Determining drivers of mast cell expansion and function during human airway disease
Project Summary/Abstract: Mast cells (MCs) expand within the airway epithelium and sub-epithelium during prevalent and burdensome human respiratory disease, including asthma and na...
Unveiling the Role of UBE2J1 as the E2 Ubiquitin Conjugating Enzyme in Androgen Receptor Degradation
PROJECT SUMMARY Despite the significant clinical success of AR-targeted therapies in the management of prostate cancer (PCa), resistance to these treatments remains a significant c...
Kynurenic Acid and Sleep: Focus on Maternal and Offspring Health
Tryptophan metabolism via the kynurenine pathway (KP) and kynurenic acid (KYNA) accumulation occurs with prenatal insults, including maternal immune activation or excessive stress....
Deltaretrovirus Morphology and Particle Assembly
Project Summary/Abstract The deltaretroviruses represent one of seven genera in the Retroviridae and are recognized as being complex retroviruses that encode for gag, pol and env a...
The Protective Role of Ceremony Against Substance Use for American Indian Adults
PROJECT SUMMARY Alcohol and other drug use inequities have devastating impacts on American Indian (AI) communities. Ojibwe ceremonial leaders assert that drug use continues to take...
Understanding and manipulating biosynthetic mechanisms for formation of terpenes relevant to human health
The Tantillo group applies modern computational chemistry to elucidate and manipulate the mechanisms by which terpenes (natural products derived from isoprene oligomers) and terpen...
Development of Integrated Precision Medicine Models in Adults with Cardiovascular Disease
PROJECT SUMMARY This application aims to use existing data within the All of Us Researcher Workbench to improve our ability to identify cardiovascular disease (CVD) patients treate...
Control of drug-reward behavior and relapse vulnerability via a specialized serotonergic-septohippocampal circuit
Summary/Abstract Recovery likelihood from substance use disorders (SUD) depends, in part, on the vulnerability magnitude for relapse. A major driver of this vulnerability is the in...
Refining and Piloting the R3 Supervision Strategy in Substance Use Disorder Treatment Programs
PROJECT SUMMARY/ABSTRACT Substance use disorders (SUDs) such as addiction to opioids, methamphetamines and alcohol are a significant burden in the US, affecting almost 50 million i...
Perineuronal nets: a new player in postoperative delirium?
Each year, approximately 10 million senior Americans suffer from postoperative delirium, a sudden brain failure that manifests after anesthesia and surgery and is characterized by...
A deep reinforcement learning framework for haplotype assembly
Haplotype assembly is the problem of reconstructing the combination of alleles on the maternally and paternally inherited chromosome copies and is key to our understanding of human...
Harnessing culturally-appropriate, technology-assisted methods to advance suicide prevention among youth in Colombian school settings
Harnessing culturally-appropriate, technology-assisted methods to advance suicide prevention among youth in Colombian school settings PROJECT SUMMARY This study will investigate a...
CD38 intensifies immune activation in women living with HIV (the CIGNAL study)
Project Summary/Abstract Worldwide, 52% of adults infected with HIV are women. Though access to effective antiretroviral therapy (ART) has increased, women living with HIV (WLWH) h...
Intestinal uptake, translocation, biodistribution, and toxicity of ingested environmentally relevant micro-nanoplastics (MNPs) and the role of inflammation using advanced cellular and in vivo models
EXECUTIVE SUMMARY/ABSTRACT After decades of increasing production of and reliance upon plastic materials, six billion metric tons of plastic waste has been deposited in our environ...
Genetically enabling Hydra oligactis for comparative studies in development, regeneration and aging.
PROJECT SUMMARY The small freshwater cnidarian Hydra has played a crucial role in several scientific breakthroughs, most notably being the first animal where regeneration was disco...
Unraveling the tolerogenic potential of lymph node fibroblastic reticular networks in autoimmune diabetes
Project Summary: Type 1 diabetes results from impaired central and peripheral tolerance mechanisms. β-cell antigen-reactive T cells escape negative selection in the thymus and regu...
The impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer's disease (AD) is a debilitating brain disorder characterized by memory loss and cognitive decline, affecting millions worldwide. The intric...
Transcriptomics-based identification of cell type specific host genes and gene networks perturbed by HSV-1 in cerebral organoids.
PROJECT SUMMARY/ABSTRACT Herpesviruses such as herpes simplex virus 1 (HSV-1) had been associated with increased risk for Alzheimer’s Disease (AD) through several seminal clinical,...
Telemedicine-delivered digital cognitive behavioral intervention to decrease post-operative opioid use among patients undergoing total knee and hip arthroplasty
PROJECT SUMMARY: Postoperative opioid prescription is an important contributor to the opioid epidemic, affecting ~4% of >50 million Americans undergoing surgery each year. The d...