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99,167 grants found
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Developing small molecules to engage an analgesic GPCR in pain unpleasantness neural circuits
For millions of patients who suffer from a variety of painful conditions, opioid analgesics can provide decisive pain relief in part by decreasing the aversion normally associated...
Administrative Core
The Administrative Core (AC) will critically contribute to the success of this drug development project, “Developing small molecules to engage an analgesic GPCR in pain unpleasantn...
Data Management Core
The breadth and multidisciplinary nature of this project entails the generation, management, and analysis of numerous distinct data types and workflows. To address this need, the D...
Validation of Therapeutic Target and Underlying Biology
ABSTRACT Research Component (RC) 1 includes the validation of novel therapeutic targets for pain and the study of their biology. In our previous work, we discovered an ensemble of...
Development and Validation of Animal Models and/or Outcome Measures
ABSTRACT Research Component (RC) 2 includes the development and validation of novel animal models that model a specific pain type, and/or the development and validation of novel ou...
Tooling for accurately studying the epigenome along the human pangenome reference
Project Summary/Abstract This proposal will provide the foundational tooling for understanding the function of the pan-genome reference through the accurate annotation of regulator...
Multimodal dendrimer theranostics targeting aggressive subtypes of prostate cancer
PROJECT SUMMARY Our ultimate goal is to develop a practical, theranostic platform for managing PC. Prostate cancer (PC) is the second most common cancer and the fifth most frequent...
State-transition and leukemia potential dynamics to inform disease evolution and adaptive therapy
PROJECT SUMMARY Acute myeloid leukemia (AML) is a group of aggressive and highly heterogeneous malignancies with poor overall survival. Despite advances in identification of molecu...
Building Tools and Community to Make Pangenomes Accessible
PROJECT ABSTRACT The human pangenome encompasses global genetic diversity missing from any single reference genome. This project will develop sequence alignment, population genetic...
Hydrolysis-resistant resin networks for durable and multifunctional dental restorations
Summary: The short average service life and the rising incidence of secondary caries currently hamper the reliability of existing dental composite restorations. This underlines the...
Heavy metals exposure regulates secretory lineage in intestinal injury
PROJECT SUMMARY Over 160,000 abandoned mine waste sites are concentrated in the western United States and continue to degrade the environment with elevated heavy metals penetrating...
Exa-scale tissue readout methods
PROJECT ABSTRACT Our brain is the most complex system under study. It relies on precise wiring and signaling across billions of neurons. Our neurons span centimeters, communicating...
The Multisensory Ontogeny of Social Behavior
Project Summary In many mammalian species, infants rely on parental caregiving to survive the vulnerable phase of early development. Considerable evidence indicates that infants ar...
A machine-learning platform to illuminate the chemical dark matter in mass spectrometry-based metabolomics
7. PROJECT SUMMARY/ABSTRACT–––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– The human body contains thousands of small molecules, and is exp...
A computational model for how risk for anxiety and depression influences affective neurodevelopment
PROJECT SUMMARY Depression and anxiety are associated with alterations in brain networks supporting emotion processing and regulation, including attention (dorsal attention [DAN],...
A hierarchical examination of the neural and computational mechanisms underlying loneliness
Project Summary In May 2023, the Surgeon General declared a public health epidemic of social isolation and loneliness in the United States. Loneliness—the subjective experience of...
The immunosuppressive function of Checkpoint kinase 2 in gliomas
Project Abstract Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate...
Expansion genomics for high-resolution single-cell and spatial epigenomics
Project Summary The diversity of cell states observed across development, aging, and disease is regulated by the epigenome, an intricate medley of chromatin states, chemical modifi...
Impact of Rural Hospital Closures on Cancer Outcomes and Cancer Racial Disparity among Medicare Beneficiaries
PROJECT SUMMARY/ABSTRACT Since 2005, 199 rural hospitals have closed in the US. These closures have resulted in a loss of primary care physicians, surgical services, limited access...
An innovative device for management of neuropathic pain after spinal cord injury
An innovative device for management of neuropathic pain after spinal cord injury Neuropathic pain (NP) after spinal cord injury (SCI) is common and debilitating, and has increasing...