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99,167 grants found
Showing 4,561 – 4,580 of 99,167 grants
Alpha-Particle Emitter Peptide Receptor Targeted Radionuclide Therapy for Neuroendocrine Tumors
PROJECT SUMMARY/ABSTRACT Peptide receptor radionuclide therapy (PRRT) with [177Lu]DOTATATE improves quality of life and survival in patients with advanced neuroendocrine tumors; ho...
Phenotype-Tailored Lifestyle intervention for Obesity: A Randomized Trial
PROJECT SUMMARY Obesity is a chronic, relapsing, and multifactorial disease, with a prevalence of 42%. Obesity treatment is challenging in clinical practice because of the physiolo...
Homeostatic plasticity in mouse models of Jordan's Syndrome
ABSTRACT Homeostatic plasticity (HP) encompasses a suite of compensatory physiological processes that stabilize neural function. It is widely hypothesized that homeostatic plastici...
Redefining Insomnia: A Comparison of Categorical and Dimensional Approaches
Project Summary Insomnia is the most common sleep disorder and negatively impacts daily functioning, quality of life, and work productivity. Despite the high prevalence of insomnia...
Signals and circuits that regulate developmental timing
PROJECT SUMMARY Deviations from the order or timing of developmental events often result in abnormalities. Understanding how such well-regulated process can remain plastic, that is...
Role of Factor XII in Thrombo-Inflammatory Complications of Sickle Cell Disease
PROJECT SUMMARY - ABSTRACT The overall goal of this proposal is to characterize Factor XII (FXII) functions in sickle cell disease (SCD) and their contribution to venous thrombosis...
Genetics and Axenic Growth of tick-borne E. chaffeensis and A. phagocytophilum
Project Summary/Abstract Human monocytic ehrlichiosis caused by Ehrlichia chaffeensis and human granulocytic anaplasmosis resulting from Anaplasma phagocytophilum are responsible f...
Pharmacogenetic Refinement of the Warfarin Dose Using Machine Learning
Warfarin is an anticoagulant that prevents venous and arterial clots but doubles the risk of major hemorrhage. Over the past decade, warfarin use has caused more medication-related...
Monitoring Listeria in vivo using 18FDG and PET scan
ABSTRACT Recently, our lab developed a novel immune therapeutic approach delivering TT as a neoantigen surrogate selectively into tumors by Listeria infection in vivo, which attrac...
Pixelated scintillators for ultra-high resolution cone-beam CT
PROJECT SUMMARY / ABSTRACTIndirect-detection x-ray Flat Panel Detectors (FPDs) use a scintillator to convert x-rays to light, which is then detected byphotodiodes coupled to readou...
THC titration of high-potency cannabis concentrates: A randomized crossover trial
PROJECT SUMMARY High-potency cannabis use is associated with public health risks, such as cannabis use disorder, psychotic disorders, and impaired cognition. Legal markets in the U...
Immune Functioning and Reward Processing in Autism
Project Summary This exploratory grant seeks to evaluate linkages between social reward processing in autism spectrum disorder (ASD) and systemic inflammation. The social motivatio...
Randomized controlled trial of a choice-driven, interactive, storytelling web-based app to investigate mental health treatment initiation among symptomatic Latinas
Abstract Most symptomatic Latina women do not receive a diagnosis or initiate mental health (MH) treatment (Tx) when warranted. Stigma, cultural concerns, distrust of professionals...
The role of neuronal ensemble Rac1 activity in cocaine seeking behavior
Project summary/abstract Cocaine addiction is a multidimensional psychiatric disorder with pathophysiology that seems to involve abnormally strong learned associations. These types...
Gene regulatory networks controlling smooth muscle phenotype and vasculardisease risk
Building on the extensive genome wide association studies (GWAS) of coronary artery disease (CAD), and single cell characterization of atherosclerosis, we have shown that the smoot...
Oncolytic HSV Immunovirotherapy for brain tumors
Glioblastoma (GBM) is a fatal cancer of the brain showing little change in survival over decades of therapeutic trials. Development of oncolytic viruses (OV) is iterative and exten...
A Schizophrenia Extension Study for the NKI Rockland Sample II project: An Open Resource of Multimodal Brain, Physiology & Behavior from a Community Lifespan Sample
ABSTRACT Schizophrenia (Sz) is a severe mental disorder that affects ~.5% of the population worldwide and is associated with significant increases in both disability and mortality....
Novel applications and translation of [18F]hGTS13, a system xc- specific radiopharmaceutical
ABSTRACT. Ferroptosis is a form of regulated cell death defined by the iron-dependent accumulation of membrane lipid peroxides that results in oxidative damage and plasma membrane...
Polymeric Micelles for Targeted Delivery of Contrast Agents Through the Nose-to-Brain Route in Image-Guided Brain Cancer Surgery
Surgery has a key role in the management of many types of brain cancers. In fact, the completion of surgical resection is a key prognostic factor in brain cancer treatment. This re...
Arsenic Exposure and its Association with Cancers among Residents with Wells in New Mexico's Border Counties
PROJECT SUMMARY. Inorganic arsenic is a known carcinogen and toxic chemical. Arsenic contamination in drinking water is an environmental public health concern in the United States...