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99,167 grants found
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Sex Difference in the Integration of Visual Social Stimulus and Emotional Auditory Stimulus
Project Summary Human mimicry, referred to as synchronization or the "chameleon effect," involves unconsciously imitating gestures, behaviors, facial expressions, speech...
Clinical Interpretation of PROMs in Care of Knee Osteoarthritis and TJR
This research will define and validate guidelines for interpretation of commonly used patient-reported outcome measures (PROMs) for pain and physical function domains among patient...
Mechanisms of Variability in the Analgesic Response to Ibuprofen Following Third Molar Extraction
PROJECT SUMMARY/ABSTRACT Nonopioid analgesics are highly effective for pain management following most dental procedures, but data suggest that prescription of opioids by dental cli...
Conjugated bile acids as nutritionally re-programmable antihypertensive metabolites
Project Summary Hypertension is the single prominent risk factor of epidemic proportions leading to cardiovascular disease and stroke, which comprise the top two reasons for mortal...
A role for pharmaceutical control of protease-activated receptor-2 for the treatment of asthma
PROJECT ABSTRACT Asthma is a heterogenous disease that impacts ~10% of the US population. It presents as a syndrome of non- specific airway hyperresponsiveness, inflammation and in...
Description of HIV social behavior using a phylogenetic model of structured co-evolution
PROJECT SUMMARY Chronic viral and bacterial infections are characterized by pathogens that are difficult to control by the host immune system and therapeutic interventions. Evasion...
Defining the Role of Viral Infections and Autoantibodies in Chronic Obstructive Pulmonary Disease Progression
PROJECT SUMMARY Multiple lines of evidence point to the role of adaptive immunity as response to viral infections and/or as misdirected autoimmune response in subjects with COPD an...
Capsid-engineered AAV vectors with Brec1-based gene therapeutics for inactivating the HIV reservoir
Abstract/Summary People living with HIV (PLWH) continue to harbor virus-infected cells despite suppression by antiretroviral therapy. These reservoir cells are the source of virus...
Institute for Clinical and Translational Science
Our goal is to build the UCI CTSA Hub as an innovative, nimble, and dynamic virtual laboratory that can implement NCATS’s bold vision for translational science. Fueled by unprecede...
Development of Allogeneic CAR T Cell Therapy for a Functional Cure of HIV Infection
Contact PD/PI: Allen, Todd M. Abstract: Antiretroviral therapy (ART) dramatically reduces HIV-associated morbidity and mortality (1). However, it is not a practical cure as eradica...
Functional Genomics Across an Ethnically and Racially Diverse Endometriosis Population
ABSTRACT Around 10% of reproductive-age women have endometriosis, although prevalence is thought to differ by ancestry, with rates the highest in Asians where around 15% of women a...
Chemical labeling strategies using biomolecule-compatible, nonaqueous media
2023. NIH MIRA project summary abstract Title: Chemical labeling strategies using biomolecule-compatible, nonaqueous media Abstract: Among many classes of chemical tools devised to...
Hypothalamic activity and collective mouse behavior in lab cages vs outdoor colonies
Project Summary Some of the most interesting and important aspects of behavior and brain function arise from social interactions. The dynamics of dyads or larger groups of animals...
Zinc Finger Protein 949 as a Potential Transcriptional Suppressor of Adipocyte Hypertrophy - Resubmission - 1
PROJECT SUMMARY Background: The cellular events that cause adipocytes to accumulate excessive amounts of triglycerides (hypertrophy), a key characteristic of obesity, remain largel...
Variant to Function Mapping of B-ALL Risk Loci
ABSTRACT Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and arises predominantly from developing B-cell precursors. B-cell ALL (B-ALL) remains a leading...
Sinus Disease in Young Children with Cystic Fibrosis
PROJECT SUMMARY/ABSTRACT Cystic fibrosis (CF) is a chronic, multi-organ process characterized by inspissated secretions that adversely impact the upper and lower airway, gastrointe...
Macrophage-fibroblast interaction is required for asbestos-induced toxicity
All organ tissues contain fibroblasts and macrophages. Emerging evidence indicates that direct interaction between fibroblasts and macrophages occur to maintain homeostasis as well...
Peptidergic Neuromodulation of the Cerebellum
ABSTRACT The cerebellum is involved in refining motor and cognitive-affective processes in diverse complex behaviors that engage neuromodulatory systems. However, how neuromodulati...
Characterization of Diverse Pediatric Cancers in LMIC Using Low-Cost Nanopore Sequencing
Project Summary / Abstract Virtually fatal 60-years ago, pediatric cancers are now curable for 85% of children who have access to contemporary treatments and robust supportive care...
Nuclear-Metabolic Interplay in Down syndrome
Abstract Down syndrome (DS) is a complex genetic disorder with significant physical, cognitive, and behavioral manifestations. Individuals with DS are also more likely to develop c...