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99,167 grants found
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IMAAP: Development and evaluation of an Interactive Mobile Asthma Action Plan
Project Summary This project will include the development and evaluation of IMAAP, an Interactive Mobile Asthma Action Plan to support asthma self-management and adherence to ‘as n...
Targeting EBV's Deubiquitinating Activity for Therapy
Project Summary/Abstract Epstein-Barr Virus (EBV), a human tumor virus, is the causative agent of mononucleosis and immunoblastic lymphomas. EBV is strongly associated with Burkitt...
Antigen specificity of plasma cells in Hidradenitis suppurativa skin lesions
Project Summary Hidradenitis suppurativa (HS) is a chronic inflammatory dermatosis that causes recurrent scarring abscesses and tunnels in the groin, axillae, and perineum. It affe...
Multivalent Small Circular mRNA Vaccines for Melanoma Combination Immunotherapy
Abstract Melanoma is the most serious type of skin cancer. Although immune checkpoint blockade (ICB) therapy has benefited many melanoma patients, most patients do not respond to c...
Macropinocytosis Inhibition as a Glutamine Mimetic Sensitization Strategy in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) cells depend on glutamine to meet their unique metabolic needs. Glutamine fuels a wide array of biosynthetic pathways; howev...
Defining the neovaginal microbiome after gender affirming vaginoplasty
Project Summary It is estimated that up to 0.6% of the US population is transgender, which describes someone whose gender identity is incompatible with their sex assigned at birth....
Dissecting and Targeting MAST1 Signaling in chemoresistant Cancers
PROJECT SUMMARY Platinum drugs such as cisplatin serve as a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome-wide RNAi screen, we identi...
Ceramides in Diastolic Heart Failure
SUMMARY This proposal explores the hypothesis that very long chain ceramides serve as a causal mediator in the structural and functional changes which underlie diastolic heart fail...
SCH: Improving Early Prediction and Decision-Making for Sepsis with Human-AI Collaboration
Early prediction and timely decision-making of acute diseases are critical to enabling early intervention and improving clinical outcomes (for example, a sepsis patient may benefit...
The Impact of Natural Disasters on Child Health
PROJECT SUMMARY/ABSTRACT Climate change is increasing the frequency, intensity, and human toll of extreme weather events such as floods and hurricanes. Children living in low and m...
Coordinating and Data Sharing Center - R&D of Vaccines and Antibodies for Pandemic Preparedness (ReVAMPP)
0BPROJECT SUMMARY/ABSTRACT The global pandemic caused by SARS-CoV-2 highlighted the continual threat of emerging and re-emerging pandemic-potential pathogens and the critical value...
Development of a Universal Vaccine Against Leptospirosis
PROJECT SUMMARY Leptospirosis, an emerging infectious disease, is a leading zoonotic cause of morbidity and mortality worldwide, conveying the greatest burden to subsistence farmer...
Evaluation of the AMPK-BACH1-NRF2 Axis as a Therapeutic Target for Inherited DCM
Dilated cardiomyopathy (DCM)-associated heart failure is a leading cause of death. About a third of all DCM is caused by variants in genes controlling heart muscle structure and/or...
Characterizing the early childhood neurodevelopmental impact of infants exposed to maternal SARS-CoV-2 infection during pregnancy
Project Abstract Pregnant people are uniquely susceptible to SARS-CoV-2 infection, with risks of severe maternal COVID-19 illness and obstetric complications. However, far less is...
Identifying and modulating pathologic T cells that govern oral mucosal immune related adverse events from immune checkpoint blockade
Immune related adverse events (irAEs) secondary to checkpoint blockade inhibition (CBI) or other immune modulatory therapy for cancer, including head and neck cancers, are a signif...
S1PR1-targeted PET imaging to predict and monitor response to HER2-targeting antibody-drug conjugates
PROJECT SUMMARY/ABSTRACT – In patients with gastric cancers who are clinically classified as HER2- positive, antibody-drug conjugates (ADC) prolong progression-free and overall sur...
Autonomic Reactivity to Restore a Dysregulated Brain-Gut Axis via Targeted Therapy
PROJECT SUMMARY/ABSTRACT Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a...
Improving Traumatic Stress in Black Women Experiencing Homelessness: Evaluation of a Stakeholder Engaged Intervention
PROJECT SUMMARY/ABSTRACT Homelessness and associated traumas disproportionately impact Black women. While women experiencing homelessness (WEH) universally face traumatic stress, B...
In vitro approaches to study human cerebellar development
PROJECT SUMMARY The human cerebellum despite its small size relative to the cerebral cortex, contains nearly 80% of all neurons in the brain. While it is classically associated wit...
Brainstem microRNA dysregulation in the pathogenesis of sudden infant death syndrome (SIDS)
PROJECT SUMMARY Despite fewer deaths as a result of the Safe Sleep campaign, the Sudden Infant Death Syndrome (SIDS) remains the leading cause of post-neonatal infant mortality in...