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99,167 grants found
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Preparation of a Phase I/II safety and efficacy trial for a cholera phage cocktail intervention
Project Summary The World Health Organization (WHO) estimates that approximately 1.3 billion people globally are at risk for cholera, a severe diarrheal disease caused by the bacte...
Developing a novel agonist of CD137 for cancer immunoprevention
PROJECT SUMMARY The primary objective of this proposal is to assess a novel agonist of 4-1BB costimulatory pathway, SA-4-1BBL, as a single agent for cancer immunoprevention in prec...
Molecular Mechanism of an Exporter-like ABC Importer YbtPQ
Bacterial infections pose one of the most significant global public health challenges, exacerbated by the emergence of antibiotic-resistant strains. As a result, treating these inf...
Elucidating the molecular mechanisms of septin-dependent drug response to the antifungal caspofungin in the human pathogen Aspergillus fumigatus
ABSTRACT Aspergillus fumigatus is the main etiological agent of invasive aspergillosis (IA). IA primarily affects immunocompromised patients and carries a mortality rate as high as...
High-risk hepatoblastoma dissemination control by oncogenic NRF2
Hepatoblastoma (HB) is the most common liver tumor in children, believed to have the fastest rising incidence of all pediatric solid tumors. Unfortunately, HB has a poor overall su...
Uterine epithelial ERα regulates preimplantation uterine immunity and sperm fitness
Project Summary/Abstract: Key early pregnancy events include fertilization, embryo development and transport, and embryo implantation. A prerequisite for fertilization in a natural...
Developing Woodchucks Susceptible to Hepatitis B Virus Infection by Modifying the Virus or Host
Abstract Chronic infection with hepatitis B virus (HBV) is a critical public health problem affecting approximately 296 million individuals worldwide and resulting in 820,000 death...
mHealth Intervention to Support Symptom Communication for Children with Cancer
PROJECT SUMMARY Inadequately managed symptoms caused by their disease and its treatment result in unnecessary suffering for children with cancer that interferes with their quality...
Title: Multi-Site Randomized Controlled Trial of a Novel Digital Application (SHIFT) to Improve Outcomes for Hematopoietic Stem Cell Transplant Survivors
PROJECT SUMMARY/ABSTRACT Overview: The goal of this study is to examine the efficacy of a novel digital application (SHIFT) for improving sexual health outcomes, quality of life (Q...
The Role of Aberrant Histone Acetylation in the Pathogenesis of Parkinson’s Disease and Related Synucleinopathies.
The underlying causes of neuronal cell loss in Parkinson's disease (PD) and related synucleinopathies, including Lewy Body Dementia (LBD) and Multiple System Atrophy (MSA), re...
Optimization of novel inhibitors of mycolic acid synthesis as TB drug candidates.
Project Summary Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is responsible for staggering levels of morbidity and mortality, with ~1.7 million deaths and ~10 mil...
Precise field-friendly methods for quantification of antimalarial drugs in dried blood spots
Project Summary/Abstract Quantification of drugs using the dried blood spots (DBS) remains uncommon due to the challenges of variability of DBS samples and correlation of DBS drug...
Role of JMJD4 in Pancreatic Cancer
PROJECT SUMMARY – Role of JMJD4 in Pancreatic Cancer In 2023, nearly 50,000 patients will die from pancreatic cancer in the US. This malignancy has one of the worst survival rates,...
Engineering synthetic feedback control in T cell signaling for anti-tumor immunity
Project Summary Engineered T cells are emerging as promising therapeutic agents against a wide variety of cancers. However, despite remarkable success against blood cancers, these...
ENsuring ACcess to optimal Therapy in CF: ENACT study
Cystic fibrosis (CF) is an autosomal recessive disorder caused by dysfunction of the CF Transmembrane Conductance Regulator (CFTR) channel. The care of patients with CF has rapidly...
Community Reservoirs of Extended-Spectrum Beta-Lactamase-producing and Multi-Drug Resistant Enterobacterales
Project Summary Enterobacterales are increasingly resistant to multiple antibiotics, making them a global epidemic public health threat. Multi-drug resistant Enterobacterales (MDR...
Evolution, transmission, and control of drug-resistant tuberculosis
This proposed research aims to investigate the emergence and transmission of multidrug resistant tuberculosis (MDR-TB) in the Republic of Moldova, which has one of the most severe...
Restoration of ependymal integrity reduces posthemorrhagic hydrocephalus in preterm neonates
Abstract About 27% of premature infants weighing less than 1500 g develop intraventricular hemorrhage (IVH). These infants suffer from post-hemorrhagic hydrocephalus, cerebral pals...
The Role of GLUT1 and Glucose in Intestinal Stem Cell Homeostasis and Regeneration
ABSTRACT. In eukaryotic cells, the facilitative glucose transporters (GLUTs) provide critical metabolic control by regulating glucose uptake rate. In the intestinal epithelial cell...
Chemoenzymatic radiosyntheses of [18F]FDG-derived oligosaccharides for S. aureus detection
PROJECT SUMMARY: The on-demand synthesis of microbe-specific PET radiotracers represents a significant challenge to their clinical translation. To be useful, these tracers must be...