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99,167 grants found
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Solutions for Organizing, Sharing and Making Discoveries from iEEG Data
Project Summary/Abstract Direct recording of neural activity from the human brain using implanted electrodes (intracranial EEG, iEEG) is a fast-growing and high-impact technique in...
Identifying cellular proteins associated with AAV genomes
PROJECT SUMMARY Recombinant adeno-associated virus (rAAV) vectors have demonstrated efficient gene transduction in preclinical gene therapy studies and are approved for clinical us...
Targeting Metabolic Vulnerabilities of Triple Negative Breast Cancer Stem Cells
PROJECT SUMMARY/ABSTRACT Triple negative breast cancer (TNBC) is the most aggressive subtype with increased propensity for metastasis and few treatment options. Mounting evidence s...
Targeted Degradation of EGFR and HER2 in NSCLC
Project Summary/Abstract Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), is an oncogenic driver that is frequently overexpressed or mutated in non-small...
Superior Colliculus Pathways for Defensive Behavior and Emotional Arousal
ABSTRACT Alterations in brain circuits underlying defensive behavior are thought to substantially contribute to the dysfunction present in anxiety disorders, which frequently emerg...
Lung Cancer Screening: Cumulative Risk and Multilevel Impact of False Positive Findings
ABSTRACT The National Lung Screening Trial demonstrated the efficacy of lung cancer screening (LCS) with low-dose computed tomography in reducing 5-year lung cancer mortality by 20...
A clinical decision tool to optimize the selection of antibiotics for patients with rifampicin-resistant Tuberculosis
PROJECT SUMMARY/ABSTRACT Tuberculosis (TB) remains a major public health concern worldwide with more than 1.4 million estimated deaths in 2022. Despite recent declines in global TB...
Dynamics of Bone ECM Assembly and Resorption
Osteoporosis, a disease of reduced bone density that leads to bone fragility, is a major clinical problem and is primarily a disease of remodeling imbalance in which bone resorptio...
Development of CapCell Scope for Metabolic Imaging of Tissue Heterogeneity and Therapy Response
Targeting and quantifying metabolic changes non-invasively is a powerful approach to facilitate diagnosis and evaluate therapeutic response. Cellular metabolism involves a vital ne...
Elucidating the innate and adaptive immune mechanism differences during viral myocarditis between pediatric and adult populations: role of sex, age and hormone status
PROJECT SUMMARY Myocarditis is a leading cause of sudden death in children and young adults but is understudied, especially in children. Viral myocarditis, inflammation of the hear...
Role of Lung Repair and Regeneration Pathways in Tuberculosis
PROJECT SUMMARY Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb), infects one-fourth of the world’s population. Majority of the infected ind...
5-base HiFi sequencing to advance the understanding of genetic determinants of pregnancy loss
SUMMARY Our program will develop a comprehensive genomic resource to characterize novel causes of unexplained recurrent pregnancy loss (RPL). We access large clinical service for R...
The Doxy-PEP Impact Study: a multi-city US longitudinal cohort to evaluate doxy-PEP field effectiveness, investigate associated antimicrobial resistance, and establish doxy-PEP to need ratios
Sexually transmitted infections (STIs) continue to rise in the US and globally, disproportionately affecting men who have sex with men (MSM) and transgender women (TW), with the hi...
Delineating the viro-immunological factors contributing to transient HIV control during consecutive analytical treatment interruptions
Project Summary During effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) persists in memory T cells and the virus from this cellular reservoir rebounds whe...
MARCH Proteins, Members of a Host Protein Family that Targets HIV
Project Summary/ Abstract Membrane Associated RING CH (MARCH) proteins are RING E3 ubiquitin ligases that are implicated in the regulation of membrane receptors. This family of ubi...
Biogenesis and function of retrotransposon-derived circular DNA
ABSTRACT Retrotransposons are highly enriched in animal genome. Their activation can rewrite the host genetic information and fundamentally impact host biology. While developmental...
Whole-body-level metabolic flux quantitation by machine learning
Project Summary Systemic diseases such as diabetes mellitus and metabolic syndrome affect multiple organs of the body. While the human body is naturally capable of self-healing, it...
Investigation of Human Gut-Derived Mesenchymal Stem Cells for Cellular Therapy
Project Summary/Abstract: Cell therapy is an innovative and non-toxic regenerative approach for the treatment of inflammatory and degenerative disorders. Mesenchymal Stromal/Stem C...
Novel antifungal agents against coccidioidomycosis
PROJECT SUMMARY. Fungal infections caused by dimorphic fungi Coccidioides immitis and Coccidioides posadasii are endemic to the southwestern parts of the United States and the sele...
miRNA buffering mechanisms and phenotypic variability in genetic syndromes
PROJECT SUMMARY The developing embryo has the remarkable ability to buffer insults, ensuring normal development in the face of genetic and environmental influences. But when these...