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99,167 grants found
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Determining the impact of peer-led community-based PrEP delivery among sexual and gender minority youth in Brazil: A randomized controlled trial
SUMMARY/ABSTRACT HIV is declining in many parts of the world, but rising in Latin America, including Brazil. From 2010 to 2019, the number of new HIV infections in Latin America in...
Pushing HIV-1 Vaccine Protection to the Mucosal Barrier
Abstract Most gene-based vaccines are replication-defective mRNA, DNA, or adenovirus (Ad) vaccines. In each case, the vaccine delivers its one copy of an antigen gene and expresses...
Puberty, diabetes, and the kidneys, when eustress becomes distress
PROJECT SUMMARY / ABSTRACT: Diabetic kidney disease (DKD) is a common and serious complication in youth with 2 diabetes (T2D). Epidemiological data implicate puberty as a major acc...
Reducing malaria in pregnancy through focal drug administration in household members: A pilot feasibility trial
PROJECT SUMMARY/ABSTRACT Malaria in pregnancy (MiP) carries substantial - but largely preventable - risks for both the pregnant woman and unborn child. Despite rigorous evidence su...
Computational genomics approaches to study mechanisms and function of mRNA splicing
Project Summary The overarching goal of this project is to understand how RNA splicing is encoded in DNA sequence and how it impacts biological function and to use this knowledge t...
Effect of TRB3 and Leucine Supplement on Beige Fat Formation
Obesity is an alarming signal for the risk of Type 2 diabetes, cardiovascular disease, and metabolic diseases in humans. Obesity results from an energy imbalance, and therefore sti...
Multi-Site Randomized Controlled Trial of a Novel Digital Application (DREAMLAND) to Improve Outcomes for Patients with Acute Myeloid Leukemia
PROJECT SUMMARY/ABSTRACT Overview: The goal of this study is to examine the efficacy of a novel digital application (app) for improving quality of life (QOL) and psychological outc...
Molecular Mechanisms Regulating Uterus Development
Project Abstract Infertility and pregnancy loss are common health disorders affecting women. Our long-term research goal is to define critical physiological and genetic pathways th...
The impact of DNA supercoiling and topoisomerases on neuronal activity-dependent chromatin organization
PROJECT SUMMARY Experience-driven changes to chromatin architecture help activate gene transcription programs that allow animals to learn and develop adaptive behaviors. Yet the fo...
Armed nanobodies as anti-infectives and anti-tumor agents
Summary A nanobody that recognizes immunoglobulin light chains, conjugated to a molecular entity that recognizes a virus-infected or a cancerous cell, is an effective therapeutic:...
Social-Ecological and Individual Determinants of the Course of Suicidal Ideation & Attempt among African Americans from Early Adolescence toYoung Adulthood
Suicide among Black youth has increased rapidly over the last two decades, reaching unprecedented levels. While there have been substantive gains in knowledge related to the etiolo...
Investigating the potential impact of a low-fat high fiber diet in limiting TBI-induced neurodegenerative and inflammatory changes.
Project Summary: The sequelae of traumatic brain injury (TBI) pathology comprises primary injury where impacting force(es) induce physical damage, including the breakdown of the bl...
Engineering of biomaterials with controlled biomolecule delivery for cardiovascular applications
Project Summary Currently, cardiovascular disease ranks as the leading cause of death in the United States. It is projected that by 2035, over 130 million adults in the U.S. will h...
Investigating alveolar macrophages in PLWH as targets for HIV persistence, residual inflammation and immune activation
ABSTRACT HIV cellular reservoirs, residual inflammation and immune activation persist despite antiretroviral therapy (ART) in people living with HIV (PLWH), and are a barrier to er...
Pathogen and immune-topographic mechanisms that underpin Candida auris skin colonization
Project Summary/Abstract: Candida auris is an emerging drug-resistant fungal pathogen that is now endemic to all inhabited continents. C. auris colonizes human skin with extraordin...
Elucidating Sex Differences in Radiation-induced Cardiotoxicity with Cell Village iPSCs
Project Summary Radiation-Induced Cardiotoxicity (RIC) remains a concerning health issue, particularly in accidental radiation exposure scenarios as evident in the Life Span Study...
Enhancing culturally safe healthcare for fasting Muslims during Ramadan
SUMMARY/ABSTRACT A. SECTION HEADER The project's long-term goal is to reduce health complications for diabetic Muslims who fast during Ramadan. This proposal focuses on unders...
Analysis of Bulk Lipid Transport at Membrane Contact Sites
ABSTRACT All eukaryotic cells face the critical problem of regulating the subcellular distribution of lipids. The lipid composition of organelle membranes is distinct, with each me...
Evolutionary Mechanisms of Enhanced Environmental Stress Resistance
PROJECT SUMMARY Cellular responses to environmental stressors (e.g., hypoxia, metals, and oxidants) are essential to animal performance and their dysregulation is associated with b...
Friend of GATA 2 (FOG2) S657G regulates ß1-adrenergic receptor and cardiac work to promote Coronary Microvascular Disease
SUMMARY Coronary Microvascular Disease (CMVD) accounts for 30-50% of ischemic heart disease and leads to angina, myocardial infarction, heart failure with preserved ejection fracti...