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Systematic investigation of disease-associated, regulatory variation; illuminating their prediction, molecular consequences and mechanisms contributing to risk of Parkinson disease (PD)
Summary – This proposal takes crucial next steps towards illuminating the mechanistic impact of regulatory variation underlying common disease risk and progression, focusing on Par...
Cataloging multi-ancestry 'omic readouts of the environmental and genetic determinants of type 2 diabetes
ABSTRACT Our proposal aims to uncover the intricate relationships between environmental, genetic, and 'omic factors in Type 2 Diabetes (T2D) development. Given the limitations...
mobile Cued Adherence Therapy (mCAT): a scalable habit formation intervention to improve blood pressure medication adherence based on a widely used smartphone app
Project Summary/Abstract. Hypertension (high blood pressure) affects 1 in 3 of the over 90 million people currently enrolled in Medicaid, and is a leading cause of cardiovascular d...
Harnessing the Pathogenesis of CMV Against HIV
PROJECT SUMMARY/ABSTRACT CD8+ cytotoxic T lymphocytes (CTLs) play a key role protective role in HIV-1 infection, but cannot fully suppress the virus because they require antigen fo...
The long-term risk of neurosyphilis in people with HIV experiencing syphilis serologic nonresponse or failure
Rates of syphilis in the U.S. have increased each year for the past 20-years and are elevated in people living with HIV (PWH). PWH are at higher risk of syphilis complications incl...
Impact of Neonatal ART and Broadly Neutralizing Antibodies on HIV-1 Reservoirs in Infants: Towards ART-free Remission
HIV-1 infection in infants persists at high rates despite efforts to prevent perinatal transmission. In 2022, an estimated 130,000 new perinatal HIV-1 infections were reported glob...
The proinflammatory functions of granzymes and their impact on endothelial inflammation/injury
Project Summary While antiretroviral therapy successfully suppresses HIV replication, immune activation and inflammation persist, albeit at lower levels, and has been associated to...
Digital Phenotyping of Anxiety and Anxiety-Related Alcohol Comorbidity and Treatment
Project Summary Anxiety and anxiety-related disorders (AARD) are notable risk factors for alcohol use problems (AUP) and their co-occurrence (AARD-AUP) results in tremendous health...
Towards a reliable and valid assessment of preteen suicidal thoughts and behavior
PROJECT SUMMARY/ABSTRACT The preteen years are a critical period in which to study the development of suicidal thoughts and behavior (STB). During this period, youth experience cha...
Establishing Mechanisms of LOX-1-Dependent Immune Regulation During Pneumonia
Abstract Pneumonia is the leading cause of infection-related deaths worldwide, a fact that is set to rise exponentially with the SARS-CoV2 pandemic. Recovery from pneumonia require...
Synthetic glycosaminoglycan mimetics as regulators of megakaryopoiesis and thrombopoiesis
PROJECT SUMMARY Title: Synthetic glycosaminoglycan mimetics as regulators of megakaryopoiesis and thrombopoiesis. Key Words: Platelets, Glycosaminoglycans, thrombopoiesis, G6b-B, N...
Nanomechanics of inner-ear hair-cell transduction
PROJECT SUMMARY Vibrations from sound and mechanical stimuli from head movements are transformed into electrochemical signals for brain processing by inner-ear hair-cell mechanorec...
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions among Latino Immigrant Families
ABSTRACT Latino immigrants experience health inequities that are heightened over time and across generations. In fact, the syndemic (conditions that cluster among marginalized grou...
ZFP36, an RNA Binding Protein that Regulates DNA Repair and Cell Proliferation in PAH
SUMMARY Pulmonary Arterial Hypertension (PAH) is a pulmonary vascular disease characterized by increased pulmonary arterial pressure. PAH patients are young, have poor life quality...
Automated Assessment of Infant Sleep/Wake States, Physical Activity, and Household Noise Using a Multimodal Wearable Device and Deep Learning Models
Sleep and physical activity/sedentary behavior are physiological and behavioral processes that are intricately intertwined. Their Interconnectedness is particularly pronounced duri...
Cultural Consensus Modeling to Identify Culturally Relevant Risk and Protective Factors for Suicide among Sexual Minority Youth
ABSTRACT Sexual minority youth report significantly higher rates of past year suicidal ideation (19.4%-30.3%) and suicide attempts (6.6%-22.7%), as compared with heterosexual stude...
Intrinsic and Extrinsic factors regulating competition for active TGFb promote skin memory CD8 T cell fitness
Abstract Resident memory T cells (Trm) are a recently appreciated subset of memory T cells that maintain long-term residence in barrier tissues. Unlike central memory T cells that...
NKCC1-KCC2 system modulation in rodent models relevant for psychiatric disorders
Summary Excitation/inhibition imbalance is considered a major factor leading to cognitive impairment and social interaction deficits in neurodevelopmental disorders (e.g. schizophr...
Linking mitochondrial and synaptic weakness to schizophrenia
Schizophrenia (SZ) is a heterogenous neurodevelopmental disorder in which the complex and interacting influences of genetics and environment drive neuropathological processes leadi...
RNA splicing factor Raver1 controls cell death, inflammation, and innateimmunity
PROJECT ABSTRACT Cell death pathways play a central role in several biological processes—from programmed cell death during the early stages of development to destroying infected ce...