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Isolation of broadly protective monoclonal antibodies for Crimean Congo Hemorrhagic Fever
Background/Rationale: Crimean-Congo Hemorrhagic Fever (CCHF) is the most widely distributed tick-borne viral hemorrhagic fever infection in the world. CCHF is potentially fatal and...
Foxp2 genetic control of sex differences in amygdala-driven social behavior
Project Summary During adolescence the brain undergoes dramatic changes that coincide with a major transition in social- emotional behaviors and is a time of enhanced vulnerability...
Decoding NSUN2-mediated translational control of pluripotent stem cells
SUMMARY A hallmark of both embryonic and adult stem cells is their dependence on low translation rates to maintain an active self-renewal and undifferentiated state independent of...
PrEP My Way: A hybrid type 1 clinical effectiveness-implementation trial to promote PrEP persistence among young Kenyan women
PROJECT SUMMARY. Significance: Young women account for 63% of all new HIV infections in sub-Saharan Africa and are thus a high priority population for pre-exposure prophylaxis (PrE...
Harnessing iron acquisition to hinder enterobacterial pathogenesis
PROJECT SUMMARY The primary objective of this application is to investigate siderophore-based immunization and antibiotic delivery strategies designed to inhibit the growth of Esch...
HIV-1 Fusion Peptide-directed Vaccine Design Using Virus-like Particles
PROJECT SUMMARY There is an unmet need in the HIV vaccine field for immunogens that consistently elicit potent serum antibodies that neutralize a broad spectrum of HIV-1 variants i...
Metabolic hormones and their involvement in the positive and negative effects of maternal exercise and obesity on synaptic development
PROJECT SUMMARY Mental health disorders are the leading cause of disability in the U.S., affecting approximately 1 in 5 people. While the causes are likely multifactorial, hippocam...
HBV cccDNA transcriptional silencing with and without HIV
Hepatitis B virus (HBV) infects >300 million people chronically and is the leading cause of end-stage liver disease and hepatocellular carcinoma (HCC), resulting in ~1 million d...
The Role of RERE and SPEN in the development of 1p36 Deletion-Related Congenital Heart Defects
ABSTRACT Congenital heart defects (CHDs) are seen in ~70% of individuals with 1p36 deletion syndrome and are a major cause of morbidity and mortality. RERE and SPEN are nuclear rec...
Structural Mechanisms of Polycystic Kidney Disease Proteins
Project Summary The human polycystin family of membrane proteins consists of versatile cellular censors classified as PKD1-like 11-transmembrane (TM)-spanning receptors (PKD1, PKD1...
Viral and Host Dynamics during Pediatric COVID-19 and Respiratory Virus Co-Infection
PROJECT SUMMARY Children infected with SARS-CoV-2 are frequently reported to have co-infection with other respiratory viruses, including respiratory syncytial virus, human rhinovir...
The Gut Microbiome and Acute Muscle Loss in Sepsis
PROJECT SUMMARY/ABSTRACT Sepsis causes profound changes in host metabolism, including acute and persistent muscle loss. Among critically ill patients, body composition (including l...
Enhanced problem-solving therapy and HIV engagement support to improve perinatal mental health and HIV outcomes in Malawi: A randomized controlled trial
ABSTRACT In sub-Saharan Africa, universal access to antiretroviral therapy (ART) for pregnant and breastfeeding persons, known as Option B+, has rapidly expanded ART access in low...
Melanocortin 4 receptor agonists to treat sleep disordered breathing in obesity
Obesity hypoventilation syndrome (OHS) is a severe form of sleep disordered breathing (SDB) characterized by daytime hypercapnia and hypoventilation during sleep. OHS is driven by...
Genetic dissection of defensin signaling in urinary tract infections
PROJECT SUMMARY Urinary tract infections (UTIs) are commonly caused by uropathogenic Escherichia coli (UPEC) and affect millions of patients, especially elderly women. Antibiotics...
Multi-omic and biological factors associated with lifespan and healthspan across NHP clades
There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging and develop new biochemical and omic methods to describe biological a...
Discovery of fused heterocyclic pyrazine based novel anti-mitotic agents for metastatic melanoma
PROJECT SUMMARY/ABSTRACT. Malignant melanoma is known to be the most aggressive and deadliest form of skin cancer. Prognosis is poor in the advanced metastatic stage with less than...
Ultrasensitive detection of Mycobacterium tuberculosis infection
PROJECT SUMMARY Tuberculosis (TB) afflicts nearly one-third of the world’s population, but progress in development of interventions is hamstrung by the slow growth rate of Mycobact...
Mechanism of neutrophil dysfunction by Plasmodium falciparum secreted histidine-rich protein II
Mechanism of neutrophil dysfunction by Plasmodium falciparum secreted histidine-rich protein II People with malaria infection caused by Plasmodium falciparum are significantly more...
The Development of Novel Disinfectants to Overcome Bacterial Resistance
Project Summary Bacterial infections cause a tremendous burden to human health, and our first line of defense – amphiphilic disinfectants and antiseptics – rely on century-old tech...