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99,167 grants found
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Chromatin remodeling factor CHD7 regulates cardiac and craniofacial lymphatic vessel development
Project Summary The anterior second heart field (SHF) cells are a population of late differentiating cardiovascular progenitor cells that contribute to myocardial cells, smooth musc...
Dissecting Hepatitis B Vaccine Adjuvant Effects on Immune Responses and the HIV Reservoir in PLWH
Project Summary Hepatitis B virus (HBV) is a leading cause of cirrhosis and liver cancer globally, resulting in over 800,000 deaths annually. Approximately 10% of people living wit...
Regulation of metabolic diseases by Clostridium immunis
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Visceral adiposity is a key risk factor for the...
Center for Clinical and Translational Sciences
PROJECT SUMMARY/ ABSTRACT Since its inception in 2006, our CCTS has assembled a well-integrated, and high-impact network in Texas including 6 academic institutions: The University...
The paradox of flavivirus antigenic non-reciprocity
Project Summary Exposure to one flavivirus can elicit immune responses that cross-react with genetically related viruses, in complex relationships with a variety of impacts on subs...
Characterizing Antiviral Washout and Viral Rebound during Analytic Treatment Interruption Studies
Project Summary/Abstract Quantifying when antiviral activity of antiretroviral therapy (ART) or novel broadly neutralizing antibodies (bnAbs) wane in people with HIV during treatme...
Role of reactive oxygen species in controlling T. gondii acute infection
PROJECT SUMMARY / ABSTRACT Toxoplasma gondii is a protozoan parasite that infects approximately one-third of humans worldwide and causes toxoplasmosis, a neglected infectious disea...
Implementing A Secure Firearm Storage Program in Illinois Health Centers in Partnership with AllianceChicago and the Illinois Primary Health Care Association
Firearms are now the leading cause of death for young people in the United States, with stark inequities for young people from minoritized communities (e.g., race, ethnicity, LGTBQ...
An Env apex-focused HIV-1 vaccine strategy
PROJECT SUMMARY What is the shortest path from the human antibody repertoire to sera that protects from an HIV-1 challenge? We propose here that this pathway starts from B-cell rec...
Deep sequencing of the HIV latent reservoir to discern mechanisms of clonal proliferation and HIV persistence
PROJECT SUMMARY/ABSTRACT The HIV latent reservoir (LR) is the major barrier to cure of HIV. The persistence of the LR in blood and tissues in people living with HIV (PLWH) during A...
Studying the modulators and the physiological functions of RNA tailing in the C. elegans oocyte
ABSTRACT The decreasing quality of oocytes, associated with maternal age, is a major component of reduced fertility in older women. Many molecular markers are observed in deteriora...
Role of PCIF1 in Regulating Host-HIV interactions
PROJECT SUMMARY RNA modification is an emerging concept because a diverse set of modified nucleotides are found in mRNA sequences. The m6A modification is catalyzed by RNA methyltr...
Regulation of fertility and reproduction by codon usage: a Drosophila model
Specialized cellular identity requires unique protein expression control. Such expression control in gametes and reproductive neurons ensures fertility. By studying cell- and tissu...
Causes and Consequences of DNA Replication Stress in the Mammalian Preimplantation Embryo
Project Summary/Abstract The genome of the early embryo provides the genetic information of the adult and thereby determines the health of a person. Surprisingly, though an intact...
Epigenetic Mechanisms in Developmental Programming of Hepatic Lipid Dysfunction by Maternal Hypercholesterolemia
Project Summary/Abstract: Maternal hypercholesterolemia (MHC) is a pathological condition of exaggerated maternal serum cholesterol during gestation. Although there is a normal ris...
Optical Genome Mapping As a Novel Diagnostic Approach in Pediatric Brain Tumors
ABSTRACT One of the greatest advances in pediatric brain tumor management has been the incorporation of tumor molecular findings in the diagnosis, prognostic stratification, and tr...
Risk factors for and consequences of endometriosis among Black women
PROJECT SUMMARY Endometriosis is a common and debilitating gynecologic disorder characterized by the presence of endometrial-like tissue outside of the uterus. It burdens approxima...
Identifying factors associated with prostate cancer progression and survival in African American men: The RESPOND Cohort
African American (AA) men have a >80% higher incidence and are more than twice as likely to die from prostate cancer (PCa) than white men. The reasons for the high burden relati...
Calprotectin and Antibiotic Activities at the Infection Interface
Calprotectin is the most abundant protein in neutrophils. Our surprising discovery that calprotectin can bind and hydrolyze multiple β-lactam antibiotics forms the basis of this pr...
Vaccine- and infection-derived correlates of protection for cholera
PROJECT SUMMARY Vibrio cholerae causes 3 million cases of cholera and 100,000 deaths annually. It also causes large and deadly epidemics of disease in areas affected by climate and...