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99,167 grants found
Showing 421 – 440 of 99,167 grants
Trained immunity as a link between Inflammatory Arthritis and development of Cardiovascular Disease
SUMMARY Trained immunity describes the relatively new observation that exposure to inflammation alters the innate immune cells, monocytes and neutrophils, to alter their behavior s...
Gene Selection for Newborn Sequencing Studies
PROJECT SUMMARY/ABSTRACT The decreasing cost and increasing robustness of genomic sequencing technologies offer an exceptional opportunity to advance the future of newborn screenin...
The Role of Airway Epithelial Complement in Chronic Beryllium Disease
PROJECT SUMMARY/ABSTRACT Beryllium (Be) is used in several industries and the US is the largest exporter of Be in the world. Despite mitigation strategies, Be exposure at the workp...
PASK-regulated genes and proteins as therapeutic targets for ALS and FTD
Project Summary/Abstract Regulation of autophagy and the nutrient-sensing kinases mTOR and AMPK are not only important in cancer, but have garnered much recent attention in neurode...
Body heat activated, storable, near-infrared, self-illuminating nanoprobes for chemiluminescence imaging of cancer
PROJECT SUMMARY The main treatment of cancer is surgery, which has shown the best overall survival rate compared to radiotherapy and chemotherapy; but after the surgery, detection...
Novel fibril-selective nanobody-based agents targeting intracellular and extracellular α-synuclein aggregates and prion-like propagation induced dementia
Summary Lewy Body Dementias (LBDs) are a series of neurodegenerative disorders characterized by accumulation of misfolded α‐synuclein (αS), including Dementia with Lewy Body (DLB),...
Mechanisms of Islet Failure in CF
PROJECT SUMMARY Diabetes is a major co-morbidity of cystic fibrosis (CF), affecting 20% of adolescents and 40-50% of adults with CF. CF-related diabetes (CFRD) is associated with w...
Couple-based prenatal contraceptive education program for economically marginalized families
Project Summary/Abstract Economically marginalized individuals face multiple barriers to consistent desired contraceptive use. Inconsistent contraceptive use in the postpartum peri...
Optimizing the Assessment of Parenting: A Multi-Method and Multi-Informant Approach
PROJECT SUMMARY Parenting plays a crucial role in youth development, influencing a myriad of health behaviors. As a result, parenting is a common focus of interventions aimed at im...
Towards Foundational 3D In Silico Models of Whole Mouse Embryogenesis
PROJECT SUMMARY A decade ago, with the advent of next-generation sequencing of the human pathogen Mycoplasma genitalium, Karr et al. reported the first whole-cell model that synthe...
Place-Based Influences on Mortality among People Experiencing Homelessness
PROJECT SUMMARY/ABSTRACT Research Challenge: More than 582,000 people in the US experience homelessness each night, and a staggering 1.25 million people enter the shelter system ea...
Understanding data-driven models for neural dynamics
Project Summary/Abstract Recent technical advances have enabled to record the activity of hundreds or thousands of neurons simulta- neously. To extract insight from this deluge of...
Spatial Regulation of Epigenetic Memory
Project Abstract: Faithful epigenetic maintenance of repression is essential to developmental processes and is frequently disrupted in diseases like cancer. Repression is maintaine...
Neural control of rhythmic orofacial movements
Abstract Major efforts to understand how brain circuits activity gives rise to perception, mental experience, and behavior have broadly advanced our understanding of most of the ce...
Synthetic protein mimetics as potential therapeutics for Lewy Body Dementia
Currently, more than 55 million people have dementia worldwide and Lewy Body Dementia (LBD) makes up to 30% of all dementia cases.There are no therapies to cure or slow down/stop t...
Role of CHAMP1, a neurodevelopmental disorder high risk gene, in human brain development and function
PROJECT SUMMARY Nonsense or missense mutations of the CHAMP1 gene, which encodes for a zinc-finger protein involved in the maintenance of kinetochore-microtubule attachment during...
The anatomical and functional study of the thymus - defining the milestones of the thymic aging in the elderly human population
The concept of this program derives from our observations that the involution of the human thymus does not follow linear kinetics and is tailored to each individual. In most humans...
Steering the next generation of NCI-sponsored clinical trials in gastroesophageal cancers
Gastrointestinal cancers, and gastroesophageal adenocarcinomas in particular, are experiencing a clinical renaissance with the approval of recent biomarker-directed therapies. With...
Assay Development and Prognostic Model for Predicting Early Clinical Failure in Follicular Lymphoma
ABSTRACT Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma (NHL) subtype with a highly variable clinical course. While asymptomatic and low-tumor burden pat...
Development of selective GPR34 antagonists for the treatment of neuropathic pain
Neuropathic pain arises from nervous system injuries due to trauma, disease, or neurotoxin exposure afflicts15-20 million people in the U.S is very difficult to treat.1-6 Currently...