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Probing the mechanisms that control DNA repair pathway choice.
Project Summary Genome maintenance is essential for accurate cell and tissue function. The underlying repair needs differ based on cell type and differentiation stage. Deciphering...
Implementation of the New Pediatric Obesity Clinical Practice Guideline in Rural Families and Clinics: A Randomized Clinical Trial
PROJECT SUMMARY/ABSTRACT Obesity poses a major health risk, contributing to elevated morbidity and mortality from cancer, cardiovascular disease, and diabetes. Children living in r...
Effectiveness of Concurrent Care to Improve Pediatric and Family Outcomes at End of Life
Title: Effectiveness of Concurrent Care to Improve Pediatric and Family Outcomes at End of Life This grant proposal represents a first competitive renewal (Cycle 2) of a highly pro...
Imaging the Pulmonary Circulation to Aid Personalized Management of Acute Respiratory Distress Syndrome
PROJECT SUMMARY Acute Respiratory distress syndrome (ARDS) is a life-threatening condition caused by widespread pulmonary inflammation leading to lung injury. ARDS has a mortality...
Optimizing Gene Therapy for Respiratory Insufficiency in Duchenne Muscular Dystrophy
PROJECT SUMMARY/ABSTRACT Duchenne muscular dystrophy (DMD) is a devastating X-linked disease with no current cure. DMD is caused by mutations in the gene encoding dystrophin. Dystr...
Unhealthy food and beverage advertising on social media: Examining state policies that restrict adolescents' access to social media
PROJECT SUMMARY/ABSTRACT Advertising of unhealthy foods and beverages to adolescents has been consistently recognized as a prominent negative determinant of child health, shaping r...
Mechanisms of CD8 TRM-mediated protection against respiratory virus transmission
PROJECT SUMMARY / ABSTRACT Respiratory virus infection and intranasal immunization generates antigen-specific T cell and B cell memory throughout the respiratory tract. This includ...
Investigating the Unexpected Nature of Specific Reading Comprehension Deficit
PROJECT SUMMARY/ABSTRACT In the United States, 67% of 4th graders are reading below proficiency, and this trend persists into adolescence (8th grade). As such, the identification a...
Investigation of host glycan requirements for the transmission of influenza viruses at the human-animal interface
Abstract Influenza A viruses (IAV) pose a constant threat to human health through both seasonal epidemics and occasional pandemics, which are often caused by transmission of IAV st...
Feasibility of Medically Tailored Meals for Pediatric Populations at Risk for Disparities in Serious Illness Outcomes due to Inequities in Food-Related Social Drivers of Health
Project Summary/Abstract Food and nutrition insecurity are clinically relevant, actionable social drivers of health (SDOH) disparities in pediatric populations experiencing serious...
Investigating the Feasibility of Combining Mindfulness Intervention and Open-Label Placebo Treatment for Chronic Pain
PROJECT SUMMARY: Chronic pain affects over one third of the U.S. population and is a leading cause of disability. Hence, there is pressing need for developing innovative, safe, and...
Dartmouth Clinical and Translational Science Institute
The COVID-19 pandemic brought into stark relief the many healthcare challenges facing individuals living in rural areas—the compounded needs of an aging population, geographic disp...
Phage-mediated horizontal gene transfer in Borrelia burgdorferi
PROJECT SUMMARY/ABSTRACT Lyme disease is caused by infection with the spirochete Borrelia (Borreliella) burgdorferi. These spirochetes are themselves infected by the phage ϕBB-1. P...
Roles of hypothalamic JMJD3 in the regulation of leptin sensitivity and energy homeostasis
Project Summary/Abstract The prevalence of obesity has reached alarming levels, impacting approximately one-third of the adult population in the United States. This epidemic poses...
Astrocyte-neuron mechanisms of glutamatergic modulation in social novelty recognition
Project Summary Social behavior is a fundamental component of complex behaviors for animals to sustain healthy living patterns. Consequently, deficits or dysfunctional social behav...
Hydrogel Targeting of Organ Specific Gene Therapy
PROJECT SUMMARY/ABSTRACT Gene therapy is a promising therapeutic strategy to treat human diseases. While vectors can be engineered to target specific cells, the blood flow greatly...
Antibody Mediated Immunity Against Brucella
Abstract: No vaccines are currently licensed to prevent human brucellosis and existing vaccines for livestock are not entirely efficacious. In humans and other animals, Brucella ca...
Adenine metabolism in cardiac repair
PROJECT SUMMARY/ABSTRACT The mammalian heart does not robustly regenerate after myocardial infarction and heals via a fibrotic repair response. Scar tissue is non-contractile, incr...
Effectiveness of teen suicide prevention with confidential care: An implementation study across 30 primary care clinics
SUMMARY Suicide among teens is a public health crisis. The Blueprint for Youth Suicide Prevention, developed by NIMH, the American Academy of Pediatrics, and American Foundation fo...
Effects of Changes in Labor and Delivery Nursing Organizational Characteristics on Obstetric Outcomes and Disparities
Effects of Changes in Labor and Delivery Nursing Organizational Characteristics on Obstetric Outcomes and Disparities The rising rates of maternal morbidity and mortality in the Un...