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Multiscale Computational Modeling to Design Patterned Tissue Assembloids for Biomanufacturing
PROJECT SUMMARY The mass production of tissues and organs is the ultimate goal of biomanufacturing, but this goal will not be achieved without the assistance of engineering design...
Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolism
Abstract We have previously shown that metformin, a biguanide commonly used for the treatment of type 2 diabetes, has robust protective effects against cigarette smoke (CS)- induce...
Defining the host and pathogen determinants of peptidoglycan induced pathophysiology in Lyme disease
ABSTRACT Accounting for ten times more cases than all of vector-borne diseases combined in the United States, Lyme disease is an escalating and pervasive problem. Upon infection wi...
The role of tyrosine metabolism in tuberculosis pathogenesis
ABSTRACT Tuberculosis (TB) is a leading cause of death globally. It remains unclear why only a small number of Mycobacterium tuberculosis (Mtb)-infected individuals progress to TB...
HPV, HIV and Oral Microbiota Interplay in Nigerian Youth (HOMINY)
PROJECT SUMMARY Despite antiretroviral therapy, people living with HIV (PLWH) have an increased risk of acquiring oral HPV and ultimately developing HPV-associated oral and orophar...
Self-Management and Glycemic Control in Adult Haitian Immigrants with Type 2 Diabetes
Morbidity and mortality rates from type 2 diabetes (T2D) are high and continue to increase, with only 32% of adults who have T2D meeting targets for glycosylated hemoglobin (A1c)....
LURN II: Enhanced Characterization of Patients with LUTS Using Biopsychosocial Approaches
ABSTRACT This application is in response to PA-20-272: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional). Sum...
Age-associated Innate Immune Dysfunction in Chronic Rhinosinusitis
Project Summary Chronic rhinosinusitis (CRS) is a common inflammatory disease that affects a large portion of the U.S. population, resulting in poor quality of life for those affec...
The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC)-Supplement
ABSTRACT Acute kidney injury (AKI) and chronic kidney disease (CKD) are “interconnected” syndromes in which each influences the other. CKD is a risk factor for AKI and AKI contribu...
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health
Project Abstract Exposure to environmental chemical mixtures may increase the risk of cardiometabolic disease. Of particular concern are prenatal exposure to perfluoroalkyl substan...
Regulation of Synaptic Vesicle Dynamics in the Auditory System
Project Summary/Abstract The ability to localize sound sources and detect temporal features of sound is fundamental to hearing. Encoding this information within the first few audit...
Combining Serotonergic Neural Progenitor Transplantation and Exercise to Improve Cardiac Disorders and Autonomic Dysreflexia After Spinal Cord Injury
Project summary Disruption of supraspinal regulation causes reduced sympathetic and unopposed parasympathetic activity, leading to cardiac and hemodynamic disorders after high-leve...
The Pathophysiology of Type 1 Versus Type 2 Mutant Calreticulin-Drivenmyeloproliferative Neoplasms
Project Summary Myeloproliferative neoplasms (MPNs) include primary myelofibrosis (PMF; characterized by the over- proliferation of megakaryocytes and granulocytes with abnormal co...
Cell-free hemoglobin-oxidized LDL-LOX-1 axis and microvascular hyperpermeability during sepsis
Sepsis, a dysregulated host response to infection with high morbidity and mortality, is characterized by a systemic inflammatory response and widespread vascular hyperpermeability...
Leveraging host-imposed metal starvation to elucidate the molecular and environmental factors that dictate metal utilization by the iron/manganese superoxide dismutase superfamily
Project Summary/Abstract: Superoxide is a toxic molecule that all organisms exposed to oxygen must cope with. This is particularly true for pathogenic microbes, as the host harness...
Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function
The NINDS Landis Award for Outstanding Mentorship is an incredible and humbling opportunity to supplement training-related activities ongoing through Dr. Corina Bondi’s R01 parent...
Imaging early development of human neural circuits
Imaging early development of human neural circuits The overall objective of this research is to create new imaging technology that dramatically improves our ability to analyze the...
Mechanism of macrophage efflux system in Mycobacterium tuberculosis pathogenesis
Project Summary Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB), a serious lung disease that affects over one third of the global population and results in ~1.5 million...
PKD3 and Valvular Heart Disease
Valvular Heart Disease (VHD) encompasses a number of common cardiovascular conditions that account for 10% to 20% of all cardiac surgical procedures in the United States. A better...
Telomerase Reverse Transcriptase in Aortic Valve Calcification
PROJECT SUMMARY Calcific aortic valve disease is a common disorder that causes substantial medical care costs and health burden. The only current therapy is aortic valve replacemen...