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Mechanisms of Base Excision DNA Repair
Abstract: DNA damage arises spontaneously from endogenous and exogenous sources and multiple DNA repair pathways are required to identify and repair sites of damage. Failure to rep...
Mechanisms of host protection during infection via the mitochondrial unfolded protein response
Project Summary Mitochondria multitask various functions such as generating vast amounts of cellular energy and regulating cell survival. Owing to their numerous cellular functions...
Negative Regulation of Osteoclastogenesis
Many pathological conditions associated with excessive bone loss are characterized by increased generation of osteoclasts, myeloid lineage cells that resorb bone. The long term goa...
CD39 in gamma delta intraepithelial lymphocyte function
PROJECT SUMMARY. Under homeostatic conditions, there is a balance between pro- and anti-inflammatory responses in the intestinal mucosa to provide a rapid response to pathogen whil...
Developing novel MR tools to optimize surgical planning and fetal outcome in TTTS
Project Summary/Abstract Twin-to-Twin Transfusion Syndrome (TTTS) is a serious complication of twin pregnancies, affecting up to 15% of twins sharing the same placenta (monochorion...
Development of 1,2,4-Triazolyl Compounds and their derivatives as a New Treatment for Tuberculosis
PROJECT SUMMARY Mycobacterium tuberculosis (Mtb) caused an estimated 1.6 million deaths in 2021. The emergence of drug- resistant strains has exacerbated the epidemic, often render...
IL-15 Therapy Combined with TGF-Beta Blockade for Sustained HIV Remission
The overall goal of this proposal is to evaluate the safety and therapeutic potential of a novel strategy towards a cure of HIV infection. The proposed treatment combines soluble I...
CREBRF Genomics, Gestational Diabetes, and Early Life Body Size in American Samoa
ABSTRACT: Childhood obesity is a significant public health problem and key risk factor for chronic conditions in adulthood. As such, there is critical need to understand childhood...
Regulation and function of subcellular RNA localization in neural crest cells and their derivatives
PROJECT SUMMARY The long-term objective of this project is to determine the general principles and causal mechanisms underlying subcellular RNA localization, and the physiological...
Impaired Renal Reserve and Preeclampsia
Preeclampsia is one of the most common and serious medical complications of pregnancy. While there are many risk factors for the development of preeclampsia, women with underlying...
Polyploidy and Sex Dimorphism in a Drosophila Tumor Model
Project Summary Ploidy variation is a cancer hallmark and is frequently associated with poor prognosis in high-grade cancers. Such variation can include an increase in chromosome s...
Mechanisms of Enzyme Regulation by Viperin in the Cellular Antiviral Response
Project Summary Eukaryotic cells have developed sophisticated defenses aimed at limiting viral replication and thereby preventing infection from escalating to other cells. This R35...
Deciphering TREM1/2 Function in Primary Brain Cancer Using a New Model of Glioblastoma
Project Summary / Abstract Glioblastoma (GBM) is an incurable primary malignant brain cancer characterized by a high degree of interpatient and intratumoral genomic and cellular he...
Olfactory and gustatory detection of aversive skin compounds by mosquitoes
ABSTRACT Mosquitoes use their olfactory and gustatory systems to find and land on a human host’s skin for a blood meal, and in the process transmit diseases like Dengue to hundreds...
Administrative Core
Administrative Core SUMMARY The Administrative Core’s overall goal is to provide administrative support to ensure the successful accomplishment of our ICEMR Center’s scientific and...
Project-004
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Project-005
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Oxidative Cysteine Modification by Thiol Isomerases in Sickle Cell Disease
Project Summary/Abstract Vaso-occlusive events represent a major clinical burden in sickle cell disease (SCD). Vaso-occlusive events recur in patients despite current treatments, i...
Brief Digitally-Enhanced Intervention for Managing Emotional Pain and Reducing Alcohol Use during Medication for OUD
ABSTRACT Heavy, problematic alcohol use is highly prevalent within individuals receiving medications for opioid use disorder (MOUD) and contributes to increased risk of opioid over...
CHIPP-PrEP: Cabotegravir-Hormone Interrogation of Pharmacokinetics/Pharmacodynamics for HIV Prevention in Cisgender and Transgender Persons
PROJECT SUMMARY____________________________________________________________________ The goal of CHIPP-PrEP: Cabotegravir-Hormone Interrogation of Pharmacokinetics/Pharmacodynamics...