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99,167 grants found
Showing 4,221 – 4,240 of 99,167 grants
Immunogenetics of COVID-19 Immune Response
PROJECT SUMMARY/ABSTRACT This application is a request for funding of a vaccine immunogenetics research program focused on identifying critical genetic and phenotypic determinants...
The Role of Modular Super-Enhancers in the Developing Murine and Human Retina
PROJECT SUMMARY During retinal development, thousands of genes change in their expression as multipotent retinal progenitor cells produce each of the 7 classes of cell types in an...
Improving prognosis prediction and therapy selection for cutaneous squamous cell carcinomas using artificial intelligence
PROJECT SUMMARY Cutaneous squamous cell carcinoma (cSCC) is a highly-prevalent form of skin cancer with an estimated 1.8M new diagnoses annually in the United States alone. While t...
Behavioral and circuit manipulations of directional tuning in Subiculum
PROJECT SUMMARY/ABSTRACT Defining the forms of neural representation and temporal dynamics of neuron ensembles in the hippocampus and related neocortical regions such as retrosplen...
The Influence of Child-Produced Speech on Infant Language Development
Project Summary Early language skills have been linked to experience with language in the real world. However, the majority of this research has focused on infant’s experiences wit...
The cell-specific neurodegenerative potential of mitochondria post-traumatic brain injury
Project Summary/Abstract This project responds to PAR-24-022 for the Trailblazer Award for new and early-stage investigators. It will test the hypothesis that injury-induced cell-s...
Alternative splicing and expression of transposable elements in aging skeletal muscle
Project Summary/Abstract Aging is associated with decline in skeletal muscle function even in healthy individuals, and the molecular mechanisms underlying this aging process are in...
Distinct NMDA receptor signaling domains regulate hippocampal network dynamics
PROJECT SUMMARY/ABSTRACT Schizophrenia is characterized by discordant thought processes, perceptions, emotional responsiveness, and social interactions impacting up to 0.7 % of the...
A Novel Mouse Model for Spontaneous and Age-Related Choroidal Neovascularization
Abstract Choroidal capillaries are normally kept behind the retina by the retinal pigment epithelium (RPE), a monolayer of cells located between the retinal parenchyma and choroida...
Identifying first-line treatment failure for earlier referral to alternative treatments in depression
Project Abstract Because not all patients with major depressive disorder (MDD) respond to standard treatments, alternative therapies such as transcranial magnetic stimulation (TMS)...
Game-based Mobile-Health Quantification of Upper-Limb Motor Performance in Children with Hemiparetic Cerebral Palsy
PROJECT SUMMARY The main goal of this research project is to test and validate a mobile health (mHealth) application to quantify upper limb motor performance in children with hemip...
Cell type specific analysis of Src kinase-NMDA receptor complexes in schizophrenia
PROJECT SUMMARY Recent evidence from genetics, neuroimaging and postmortem studies collectively points to synaptic pathways as a locus of pathophysiologic mechanisms of schizophren...
Integrating Climate Impacts into a Community Health Assessment for Rural Communities
PROJECT SUMMARY The science is overwhelming that our planet is changing, and these climatic changes are exerting catastrophic pressures on local communities, with little time to re...
Ubiquitination of Mitochondrial Proteins in Alzheimer's Disease
PROJECT SUMMARY/ABSTRACT Extensive studies have observed impaired mitochondria in patients and animal models of Alzheimer’s disease (AD). Specifically, a large body of research has...
Unraveling the Interplay Between Self-Organization and Antimicrobial Resistance Evolution Across Spatial Scales
Title: Unraveling the Interplay Between Self-Organization and Antimicrobial Resistance Evolution Across Spatial Scales The rise of antimicrobial resistance (AMR) is a serious threa...
Interrogating the Spatial and Functional Relevance of Microbes in Pancreatic Cancer and Metastasis
Abstract/ Summary Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive malignancies, with more than 50% of patients with pancreatic cancer presenting with...
Olfactory neuromodulation: genes, cells, and behavior
PROJECT SUMMARY Day/night cycles profoundly impact animals’ physiology and behavior to allow adaptation to rhythmic environmental cues. Daily rhythmic behaviors are believed to be...
Integrated epidemiology of systemic and plaque-specific immunologic features of human atherosclerosis
SUMMARY - Subclinical atherosclerotic cardiovascular disease (ASCVD) occurs in more than half of adults over 50 and progresses in many to clinical ASCVD events such as myocardial i...
Chemical biological analysis of RAF Kinases
Abstract The serine/threonine Raf Kinases function as downstream modulators of RAS GTPase-driven signaling and are key drivers of many oncogenic signaling networks. Despite extensi...
Assessing Neuronal Vulnerability in the Entorhinal Cortex due to Alzheimer's Disease Pathology
PROJECT SUMMARY Understanding how specific neurons in a selectively vulnerable region such as the EC are affected is critical to unraveling the mechanisms underlying Alzheimer'...