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99,167 grants found
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Within-Year Debt Fluctuations, Stress, and Health
PROJECT SUMMARY Lower-income Americans increasingly rely on a range of unsecured debt sources (e.g., credit cards, payday loans) to help manage expenses, likely contributing to fre...
Helpline Delivery of Brief Interventions for Postpartum Heavy Episodic Drinking
Abstract The proposed R34 will develop and test digital helpline intervention components aimed at reducing heavy episodic drinking (HED) during the first 3 months postpartum. HED i...
Pathogenic mechanisms of TMJ osteophyte formation
Abstract The temporomandibular joint (TMJ) controls the movement of the jaw but is susceptible to acquired diseases, including osteoarthritis (OA). Osteophytes, referred to as fibr...
SILOS: Structural Inequities across Layers Of Social-Context as Drivers of HIV and Substance Use
PROJECT SUMMARY Racial, ethnic, and sexual and gender minority populations are disproportionately impacted by HIV and substance use, with Black men who have sex with men (BMSM) and...
'Omics predictors of Sickle Cell Severity and Survival
ABSTRACT Sickle cell disease (SCD) results in premature aging and early mortality. Although we (using >15-years follow up [f/u]) and others have shown that life expectancy in SC...
Imaging of cerebral microvascular pulsatility in cerebral small vessel disease
PROJECT SUMMARY/ABSTRACT Cerebral small vessel disease (cSVD) is a major public health challenge, responsible for approximately 30% of strokes and at least 40% of dementia cases. c...
Investigating Endocytic Mechanisms in Lysosome Rich Enterocytes
ABSTRACT Nutrient absorption in the neonatal mammalian gut relies on intracellular digestion by a population of enterocytes known as vacuolated or neonatal enterocytes. Recently, w...
Disability Perspectives on the Adverse Health Effects of Medical Ableism
PROJECT SUMMARY A growing body of research shows that ableist attitudes and beliefs are widespread among healthcare providers and that many healthcare settings still lack necessary...
Mechanisms of serotonin and serotonin receptor biology in normal and glaucomatous retinas
PROJECT SUMMARY Glaucoma is a progressive disease of retinal ganglion cells (RGCs) and their axons. Some evidence suggests that oral SSRIs (selective serotonin reuptake inhibitors)...
Defining the Neuro-Immune and Placental Profile of a Dual-Hit Toll-like Receptor 7 and Stressor Mouse Model
Project Summary Maternal infection during pregnancy increases the risk of neuropsychiatric disorders. Although maternal immune activation during pregnancy is a strong risk factor f...
Gene-environment Interplay Among Modifiable Factors for AD/ADRD: Risk and Resilience Across the Lifespan
Project Summary/Abstract The proposed project will leverage 16 twin samples from the Interplay of Genes and Environments across Studies (IGEMS) Consortium, and incorporate four add...
Environmental Exposome as a Driver of Race/Ethnicity Differences in Alzheimer's Disease
Project Summary This project seeks to examine the role of the exposome as a significant risk factor for Alzheimer's disease (AD) among non-Hispanic whites, African Americans a...
Community-driven drug prevention implementation strategies for Native Hawaiian and Pacific Islander youth in rural Hawai'i
PROJECT SUMMARY/ABSTRACT I am an implementation scientist, youth substance use and mental health services researcher, clinical psychologist, and descendant of Okinawan-Japanese imm...
Examining the relationship between blood-based mitochondrial bioenergetic capacity in frozen samples, socioeconomic position, and physical functioning
Physical function in older age is among the best predictors of independence and disability. Social determinants of health (SDOH) play a critical role in shaping physical function....
College Health Provider Attitudes and Practices Regarding HPV Vaccine
Program Director/Principal Investigator (Last, First, Middle): Liebermann, Erica Project Summary/Abstract Human papillomavirus (HPV) is the most common sexually transmitted infecti...
Peer Behavioral Activation Utilization to Address Structural Racism and Discrimination and Improve HIV Outcomes in High-Risk, Substance-Using Populations- PUSH
Background. Substance use continues to be a major driver of HIV acquisition and has been associated with suboptimal ART adherence, treatment interruption, and inability to achieve...
Functional Networks of White Matter in Alzheimer's Disease and their Associations with Cognitive Decline
Alzheimer's disease (AD) is a neurodegenerative disorder that affects a patient’s memory, language, and executive function. AD affects one in nine (>10%) in the US aged 65-...
TNFR2 blockade prevention of STI infertility
Project Summary Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection worldwide, and public health measures including test-and-treat strategies hav...
The role of limbal fibroblasts for the maintenance of limbal stem cells
Project Summary / Abstract Corneal epithelium is maintained by stem cells residing in the limbus, the area between the cornea and conjunctiva. These stem cells are known as limbal...
Ultrasound for bedside characterization of swallowing biomechanical impairments and biofeedback
Project Summary/Abstract Older adults are at risk for developing swallowing disorders (dysphagia) due to advancing age coupled with complicating comorbid diseases. Dysphagia is def...