Browse All Grants
99,167 grants found
Showing 401 – 420 of 99,167 grants
Synchronizing Oscillatory Brain Activity to Treat Post-Stroke Aphasia
PROJECT SUMMARY/ABSTRACT Transcranial alternating current stimulation (tACS) is increasingly used to enhance perceptual and cognitive performance in healthy individuals and in indi...
Visualizing and Manipulating Neuronal ESCRT Dynamics in vivo
PROJECT SUMMARY The aim of this proposal is to elucidate how ESCRT (Endosomal Sorting Complex Required for Transport) machinery is regulated and deployed in neurons. ESCRT is a set...
The Role of KBTBD2 in Bone Development and SHORT Syndrome
PROJECT SUMMARY Childhood growth disorders have significant consequences in adult life, including body size, work and reproductive performance, and the risk of chronic diseases. Ou...
Thalmocortical interactions in taste perception
PROJECT SUMMARY Cortical taste responses reflect sensory stimulation, perception, and behavioral decisions. These responses are the result of interactions among several brain areas...
Molecular Signaling in Dentinogenesis and Dental Caries Risk
ABSTRACT Dental Caries is one of the most common chronic diseases worldwide, and one of the most understudied conditions in patients with rare diseases, critically undervalued in h...
Elucidating the mechanisms of ependymal ciliary signaling
ABSTRACT Ependymal motile cilia are responsible for the coordinated movement of cerebrospinal fluid (CSF) along the ventricle wall. The synchronized activity of ependymal cilia cre...
Algorithmic Analyses of Accelerometry Data to Capture Meaningful Upper Extremity Use and Recovery Following Distal Radius Fracture Repair
Project Summary/Abstract Distal radius fractures (DRF) are the most common upper extremity fracture. They disproportionately affect older women, and the overall incidence is increa...
Investigating the therapeutic potential of maternal breast milk components for preterm white matter injury
SUMMARY White matter injury (WMI) is the most common type of brain injury in premature infants and is associated with adverse neurological outcomes, including motor and cognitive d...
Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia
Project Summary Although mild post-stroke aphasia is often disabling, there are no accepted treatments for this condition. Transcranial Magnetic Stimulation (TMS) in conjunction wi...
Human Craniosynostosis Atlas (HuCA) : Standardizing & Establishing a Public Repository for Genomic and Imaging data
R21: Human Craniosynostosis Atlas (HuCA) : Standardizing & Establishing a Public Repository for Genomic and Imaging data. Project Abstract: Craniosynostosis is a premature fusi...
Clinic-Community Bridge-to-Care Initiative: Trauma and Violence Informed Care (TVIC) with Women Survivors of Intimate Partner Violence (IPV) and Living with HIV/AIDS
Abstract Johns Hopkins John G. Bartlett Specialty Practice (JGBSP) and Johns Hopkins HIV Women's Health Program (JHHWHP) provides comprehensive HIV care and treatment to women...
Dynamic collagen architecture influence on mechanics of dystrophic skeletal muscle
Fibrosis, which is the pathologic accumulation of extracellular matrix (ECM), is one of the main traits of Duchenne muscular dystrophy (DMD) and many other muscle pathologies. Fibr...
Hermanas de Corazón: A Community Health Worker Initiative for improving Heart Health in Migrant Latina Farmworker Women
ABSTRACT Cardiovascular disease (CVD) is the leading cause of death of U.S. women with CVD mortality increasing in reproductive-age women. Rural, migrant Latina farmworker women ha...
Advancing Equity in Rare Disease Genomics
Project Summary Genomic research presents a unique opportunity for molecular diagnosis of individuals with rare disease, which may empower precision therapies to alleviate the indi...
Patterning Mechanisms for Ventricular Septation and Congenital Heart Disease
PROJECT SUMMARY The most common congenital heart disease (CHD) in children involves incomplete formation of the interventricular septum (IVS), which occurs in isolation or as part...
Effect of RCR healing on degenerative shoulder changes and 5y clinical outcomes
Project Summary—Abstract Healing following rotator cuff repair (RCR) remains a significant clinical challenge. While most patients report improvements in clinical outcomes, approxi...
Mechanisms of paired vagus nerve stimulation in human chronic stroke
After stroke, upper extremity (UE) motor impairment is especially disabling and has few effective therapies. Vagus nerve stimulation paired with rehabilitation training (paired VNS...
Exploring the unknown function of LRRC55 in pain
SUMMARY The opioid pandemic highlights the urgent needs to understand pain mechanisms and identify novel, non-opioid therapeutic targets to treat pain. Ion channels involve in almo...
Pediatric acute lymphoblastic leukemia: Improving outcomes through incorporation of novel targeted therapies into treatment for relapsed and newly diagnosed disease
O’Brien R50 Research Specialist (Clinician Scientist) Project Summary/Abstract While many children with acute lymphoblastic leukemia (ALL) are cured with frontline therapy, for tho...
MetaboCore: Needle biopsy assay of drug sensitivity for solid tumors.
Abstract The goal of personalized oncology is to select the most appropriate drug(s) for individual cancers. A number of platforms (e.g., organoids and PDX mice) have been develope...