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99,167 grants found
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Kinase Signaling in Epidermal Homeostasis and Early Neoplasia
PROJECT SUMMARY Kinases are essential to development and deregulation of their activity contributes to cancer progression in multiple human malignancies. We recently demonstrated t...
A Mechanoimmunological Basis for Metastatic Site Preference
Summary Antitumor immunosurveillance by cytotoxic lymphocytes is generally conceived as a biochemical process in which tumor specific markers are recognized by activating receptors...
Colorectal Cancer Screening with Optical Coherence Tomography
The overall incidence rate of colorectal cancer (CRC) has declined over the past two decades largely due to population-based colonoscopic screening for and removal of precursor ade...
Evaluating Over Constraint of the Patella following MPFL Reconstruction as a Contributing Factor to Progressive Cartilage Degradation
Project Summary/Abstract Lateral patellar dislocation is a common traumatic injury for young, active subjects. Approximately 50% of patients progress to symptomatic patellofemoral...
Expanding Genetic Understanding of Depression, Anxiety, and their Treatments
ABSTRACT Major depressive disorder (MDD) and anxiety disorders (ANX) are genetically related traits that cause very substantial morbidity and mortality worldwide. The large, divers...
Novel PET Imaging to Guide Therapy in Hepatocellular Carcinoma
PROJECT SUMMARY/ABSTRACT: Novel PET Imaging to Guide Therapy in Hepatocellular Carcinoma Liver cancer is the third leading cause of cancer death worldwide, with hepatocellular carc...
Yale Diagnostic Center of Excellence for Undiagnosed Diseases
SUMMARYUndiagnosed disease remains a major burden for millions of Americans and their families. Here, we propose the Yale Diagnostic Center of Excellence (YDCoE) as a new site for...
Non-invasive MRI mapping of BBB water exchange rate and permeability
Project Summary/Abstract The blood-brain barrier (BBB) plays a crucial role in protecting the central nervous system (CNS) from harmful substances such as plasma proteins and inorg...
Indiana Collaborative for Undiagnosed Rare Disease
SUMMARYA rare disease is a condition that affects fewer than 200,000 people in the United States or 1 in 2,000 individuals in the general population. There are approximately 7000 d...
Cellular diversity in the superior olivary complex underlying timing- and intensity-based sound localization
Project abstract The superior olivary complex (SOC) in the brainstem of mammals integrates information from the two ears enabling sound localization. This ability underlies selecti...
Randomized controlled trial of FoRtitude: Targeted eHealth intervention to reduce fear of recurrence among breast cancer survivors in community oncology settings
PROJECT SUMMARY Fear of recurrence (FoR) is a pervasive, distressing concern among breast cancer survivors (BCS) that persists for years after cancer treatment. Long-term survivors...
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor Progression
PROJECT SUMMARY: 30 lines. The canonical phosphoinositide (PI) 3-kinase (PI3K)/Akt signaling pathway uses free membrane PI lipid to regulate cell growth and is frequently hyperacti...
Modulation of Ca2+ -activated K+ channels by CFTR Correctors
Cystic fibrosis (CF) results from mutations in the CFTR Cl- channel resulting in diminished transepithelial Cl- secretion. The most common CFTR mutation, F508del, results in a chan...
Intersecting clinical, genomic, and experimental investigation to understand the mechanisms and impact of coronary artery patterning
PROJECT SUMMARY/ABSTRACT Coronary artery disease (CAD) remains a leading cause of death despite the availability of lifesaving pharma- cological and mechanical interventions. Compl...
The Role of Copper in Choroid Plexus
PROJECT SUMMARY Copper (Cu) has a critical and multifaceted role in the development and function of mammalian brain. Cu misbalance is observed in many disorders affecting the centr...
Intelligent and Personalized Online Adaptive Proton Therapy
Project Summary/Abstract The Bragg peak serves as the foundation for proton radiotherapy (RT), providing particular benefit to reducetreatment toxicity and improve quality of life...
Overcoming epigenetic barriers to somatic cell reprogramming by the XPC DNA repair complex
PROJECT SUMMARY/ABSTRACT. Thymine DNA glycosylase (TDG) is a key enzyme in somatic cell reprogramming. TDG catalyzes DNA demethylation and reactivation of specific sets of genes to...
The Role of Red Blood Cell in Stroke-Related Hyperglycemia
Project Summary/Abstract Acute hyperglycemia following an ischemic stroke is a significant contributor to poor clinical outcome, even though it is temporary. While intensive insuli...
CD200R blockade for cancer immunotherapy
PROJECT SUMMARY Immunotherapies based on the blockade of immune checkpoints have revolutionized cancer treatment in recent years. Today, immune checkpoint inhibitors in development...
α9α10 Nicotinic Acetylcholine Receptors in neuropathic pain
ABSTRACT Chronic pain represents a serious and growing health concern that affects at least one in five American adults. Despite the high risk of tolerance, physical dependence, an...