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99,167 grants found
Showing 4,141 – 4,160 of 99,167 grants
Assessing the Effects of EHR Optimization Interventions in Primary Care
ABSTRACT Fifteen years after passage of the HITECH Act resulted in investment of billions of dollars into electronic health record (EHR) adoption, physicians and health system lead...
Mechanisms of Cholinergic Signaling in the Inferior Colliculus
Our long-term goal is to determine how cholinergic signaling drives adaptive sound processing in the auditory midbrain and how this computational flexibility is altered in auditory...
Harnessing DNA methylation in peripheral blood for improved colorectal cancer prevention
PROJECT SUMMARY / ABSTRACT DNA methylation (DNAm) aberrancies are hallmarks of colorectal cancer (CRC) and substantially outnumber somatic mutations. So far, most DNAm studies have...
Epigenetic mechanisms controlling single-stranded DNA lesion sensitivity and mutagenesis
Project Summary: Our long-term objective is to define the epigenetic mechanisms that ensure accurate genome maintenance, and to exploit these findings to improve human health. Sing...
Caspase-8 mediated control of CNS infection
PROJECT SUMMARY The brain is a unique environment in the context of infection. Many brain cells are long-lived and irreplaceable. To combat central nervous system (CNS) infection,...
Mechanisms of DUX4-induced misregulation of RNA processing and quality control
PROJECT SUMMARY Facioscapulohumeral muscular dystrophy (FSHD) is a devastating muscle disease caused by the inappropriate expression of an early embryonic transcription factor, DUX...
Multi-omic approaches to identify novel biomarkers for the diagnosis of syphilis in pregnancy and assessment of treatment response
ABSTRACT Congenital syphilis (CS) rates are rising exponentially in the United State. Syphilis in pregnancy is associated with miscarriage, stillbirth, early infant death, low birt...
Development of "Face-Forward-Web": A novel web-based program targeting pain-related outcomes among patients with heterogeneous chronic orofacial pain
PROJECT SUMMARY Background: Chronic orofacial pain (COP) conditions are common, costly, and debilitating. These conditions are unified by high levels of pain-related activity limit...
Characterization of the nascent retinal proteome regulating Hippo signaling during damage
PROJECT SUMMARY/ABSTRACT Retinal degenerative diseases such as age-related macular degeneration and glaucoma, as well as traumaticinjury, typically lead to loss of retinal neurons...
Mount Sinai Center for Undiagnosed Diseases
We propose an Undiagnosed Diseases Network (UDN) Diagnostic Center of Excellence (DCoE) at the Mount Sinai Health System (MSHS) and the Icahn School of Medicine at Mount Sinai (ISM...
Geographic Variations in Health Care: Overcoming Bias, Expanding Generalizability, and Improving Relevance
PROJECT SUMMARY A substantial amount of research over the past 50-years involving Medicare and other health insurance claims data has focused on evaluating variation in health care...
Southern California Undiagnosed Disease Network
PROJECT SUMMARYRare diseases have a negative impact on the quality of life of patients, who are left on the road of a psychologically challenging, expensive and uncertain diagnosti...
CPMV-Polymer Devices to Enhance the Outcomes of Intratumoral Immunotherapy
CPMV-Polymer Devices to Enhance the Outcomes of Intratumoral Immunotherapy Steinmetz (PI) and her colleagues have developed a plant virus nanoparticle immunotherapy that activates...
Calcium imaging-based insights and guidance of deep brain stimulation to enhance chronic, post-stroke rehabilitation in a rodent model of ischemia
Project Summary Current post-stroke rehabilitation treatments assist only ~50% of patients, resulting in an urgent need to develop new therapies for the millions of individuals who...
Addressing the Research Gap in Mitochondrial Myopathy with Validated Outcome Measures and Natural History
ABSTRACT Primary Mitochondrial disease (PMD) is a clinically heterogeneous group of >350 gene disorders due to pathogenic or likely pathogenic variants in either nuclear DNA or...
Sensory-evoked adenosine release in cortical plasticity
Abstract Neural circuits in sensory cortices are plastic, i.e., their properties change as new environmental information is integrated based on its behavioral value. The capacity o...
Modular Toolbox of Protein and Lipid Hybrid Biomaterials for siRNA Delivery
ABSTRACT/PROJECT DESCRIPTION: Technologies for gene delivery are desperately needed to address a wide array of pathological processes in the various tissues of the body. In particu...
COPD GWAS Functional Variant Identification in Airway Epithelial Cells using Deep Learning Splicing Models
Project Summary: Chronic obstructive pulmonary disease (COPD) is a debilitating disease for which new, disease-modifying treatments are desperately needed. Since drug targets suppo...
Individualized Mechanisms of Neural Plasticity and Response to Interventions in Neonates
Psychiatric disorders affect up to 30% of all youth prior to age 18, can be highly impairing, and up to 50% of affected children remain symptomatic despite the best available treat...
Increasing Diversity, Diagnostic Yield, and Efficiency in Clinical Evaluations of Rare Disorders
The University of Alabama at Birmingham (UAB) Undiagnosed Diseases Program (UAB UDP) was established as a fee-for-service clinical program in 2013 with support by UAB Medicine.The...