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99,167 grants found
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Financial Hardship among LGBTQ+ Cancer Survivors and Caregivers: Prevalence, Determinants, and Access to Care
Abstract Significance: Lesbian, gay, bisexual, transgender and other sexual and gender minority (LGBTQ+) populations make up a substantial proportion of the United States (US) popu...
Associations between neighborhood environments across the life course and Alzheimer's disease and related dementia outcomes among Hispanic older adults born in and outside the US
PROJECT SUMMARY Hispanic older adults are 1.5 times more likely to develop Alzheimer’s disease and related dementias (ADRD) compared to White older adults. Social and built environ...
Comparison of behaviorally-based remote approaches to optimize weight loss and identification of factors which characterize treatment response
PROJECT SUMMARY In-person behavioral weight loss (WL) programs are the gold standard of obesity treatment, but remote-based interventions are becoming increasingly utilized as they...
Treating Complex Sentences in Children with DLD
Abstract Children increasingly confront complex sentences as they progress through the school years. Sentence structures including passives and relative clauses are specifically me...
Machine Learning Based Analysis of Longitudinal Changes in the Congenital Heart Disease Electrocardiogram
PROJECT SUMMARY Delayed intervention for congenital heart defect residua and sequelae can lead to heart failure and end-organ damage. Identifying the optimal time for intervention...
Regulation of Neonatal Lung Inflammation by Novel Innate Immune Mechanisms
Abstract Prematurity-related chronic respiratory disease, including bronchopulmonary dysplasia (BPD), is associated with high morbidity, healthcare use, and expenditures. Inflammat...
Elucidating T Cell Ferroptosis in Renal Medullary Carcinoma: 3D Genome Architecture Rewiring and Therapeutic Alleviation
Project Summary The three-dimensional (3D) chromatin architecture in mammals represents a remarkable yet not fully understood biological process. The high-throughput chromosome con...
Expansion and application of synthetic biology tools for natural products discovery from myxobacteria
Project Summary Natural products produced by bacteria are a critical resource for discovery of new therapeutics. Synthetic biology approaches such as heterologous expression of bio...
Acupuncture for Medicare Beneficiaries with Chronic Low Back Pain: Access, Utilization, and Outcomes
SUMMARY In 2020, following a thorough assessment of the scientific evidence on acupuncture, the Centers for Medicare & Medicaid Services (CMS) issued the decision to initiate c...
Primary Care Referrals to a Remotely Delivered Physical Activity Intervention for Latina Teens
PROJECT SUMMARY Latina adolescents report especially low activity,2,3 being less than half as likely to meet physical activity guidelines as Latino boys. Compared to non-Latino Whi...
The function role of salivary piRNAs in oral wound healing
PROJECT SUMMARY/ABSTRACT The oral mucosa is constantly exposed to a bacteria-rich environment coupled with continual physical trauma. For patients, chronic oral wounds aren't...
Circuit Defects Underlying Deficits in Social Touch in Fragile X Syndrome
ABSTRACT Sensory hypersensitivity and the resulting avoidance behaviors represent a major challenge for most individuals with Fragile X syndrome (FXS) and for many autistic people....
Investigating and targeting the translational landscape of DBA
In ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes, such as limb and craniofacial defects as well as bone marrow failure. A key exa...
Released peptidoglycan fragments are a biomarker for early stages of syphilis
ABSTRACT. Syphilis is a sexually transmitted bacterial infection that has plagued human health for nearly five centuries. Over the past 30-years, syphilis cases have skyrocketed, w...
Parallel-group randomized controlled trial of Pioglitazone versus empagliflozin for T3cDM: The PEP-DM Trial
ABSTRACT Chronic pancreatitis (CP) and recurrent acute pancreatitis (RAP) continue to increase worldwide and in the U.S. and are associated with Diabetes Mellitus (CP-DM). Observat...
4D virtual Catheter (4D vCath) for multi-factorial hemodynamics in pulmonary hypertension
SUMMARY: Pulmonary Hypertension (PH) is a severe and life-threatening disease that increases mortality rates by 7-fold. Pulmonary Arterial Hypertension (PAH, WHO Group 1) is the mo...
Investigating how SUT-6/NIPP1 regulates pathological tau
Background: Alzheimer’s disease and other neurodegenerative diseases with accumulation of pathological tau protein, termed tauopathies, are increasing in prevalence and burden to t...
Medicare Advantage versus Traditional Medicare for Dual Eligible Beneficiaries
Project Summary/Abstract Dual-eligible Medicare and Medicaid beneficiaries (“duals”) frequently have complex clinical and social needs. Compared with non-duals, dual beneficiaries...
Modulating cysteine metabolism to induce cell death in small cell lung cancer
SUMMARY Small cell lung cancer (SCLC) is a fatal form of lung cancer whose development is closely associated with tobacco smoking. Patients with SCLC have a median overall survival...
Sensorimotor Basis of Speech Motor Learning and Retention
Project Summary / Abstract This project will test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not o...