Browse All Grants
99,167 grants found
Showing 4,081 – 4,100 of 99,167 grants
CROSSTALK BETWEEN GUT MICROBIOTA AND HEPATOCELLULAR CARCINOMA INDUCED BY METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE
Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered a world-wide public health problem caused by metabolic syndrome. It is estimated that 30% of the worl...
LRRC57 modulates neurotrophic growth factor signaling in synaptic function and behavior
Abstract Our understanding of the biology of neuropsychiatric disease is still in the early stages. Genome-wide association studies have identified multiple genomic loci associated...
Examining the Feasibility and Effectiveness of an mHealth Solution Designed to Enhance Clinical Outcomes Among Patients Attending Physical Therapy for Musculoskeletal Pain
Musculoskeletal (MSK) pain is a major burden on the US population, representing the leading cause of disability and non-cancer reason for opioids prescriptions, as well as the top...
Conditional knock-in of Gnb3/Gngt2 in mouse rod photoreceptors
ABSTRACT. The G-protein Gb3 subunit encoded by the gene GNB3, is the protein present in multiple tissues and cell types, including retinal cone photoreceptors, as part of the Gabg...
Pleiotropic pathways of extracellular calcium sensing
Summary The human calcium-sensing receptor (CaSR) detects fluctuations in the circulating Ca2+ concentration and maintains extracellular Ca2+ homeostasis by regulating parathyroid...
Sleep to Reduce Incident Depression Effectively in Peripartum - (STRIDE P)
Project Abstract. Perinatal depression (PND) affects nearly 20% of pregnant and postpartum women, with estimates soaring above 30% during the COVID-19 pandemic. Prospective data sh...
Rapid and Robust Pediatric MRI
Project Abstract Motivation: This is a successor application of our successful project, Rapid Robust Pediatric MRI, R01 EB009690. MRI offers superb soft tissue contrast for childre...
An axolotl embryogenesis single-cell reference atlas to enable lineage-based developmental and regenerative studies
PROJECT SUMMARY Human patients who lose limbs due to injury or disease are faced with profound challenges for the rest of their lives. Prostheses, while increasingly sophisticated,...
Dysregulation of uterine fluid movement as a mechanism of contraception
Project Summary / Abstract Timely and coordinated hormonal levels are essential for establishing a natural early pregnancy. Therefore, hormonal contraceptives have been employed as...
Development of aerosol fluorescence spectrometer for measuring multiple physicochemical properties of respiratory and drug particles in situ
The key physicochemical properties of phase state, viscosity, and pH of aerosols and droplets impact both the transmission of respiratory viruses and the efficacy of drug delivery...
Hybrid Effectiveness-Implementation Trial to Evaluate a Scalable, Peer-Delivered Intervention for Depression among People with Substance Use Disorder in a Certified Community Behavioral Health Clinic
Low-income, racial/ethnic minoritized individuals, especially people of color living in impoverished communities, have limited access to evidence-based interventions (EBIs) for men...
Enhancing Breastfeeding Outcomes through Digital Phenotyping
Project Summary/Abstract: This research proposal responds to the pressing need for comprehensive understanding and targeted support in breastfeeding outcomes, an area significantly...
Suicidal Behavior among Adolescents Experiencing Homelessness in the US during the COVID-19 Pandemic
PROJECT SUMMARY Suicide is a major public health problem in the U.S., ranking as the second leading cause of death among teens, with a rate of 7.1 per 100,000 population in this ag...
Development of a novel model to study the effects of LINE-1 retrotransposons in disease and normal physiology using nanobodies
LINE-1 retrotransposons encode a multicistronic enzymatic complex with three open reading frames. Thousands of copies of LINE-1 are embedded throughout the genome, and the enzyme a...
Development of human taste organoid models
The sense of taste is mediated by taste buds on the tongue. Each bud is a heterogeneous collection of taste receptor cells (TRCs), and all TRCs, which transduce sweet, bitter, salt...
Nonresponse of Patient-reported Outcomes in Routine Cancer Care
PROJECT SUMMARY/ABSTRACT Patient-reported outcome (PRO) measures, or PROMs, are powerful tools in cancer care to enhance clinician- patient communication, identify problematic symp...
Functional characterization of clinically-identified coding variants in the transcription factor gene ZEB2
Project Summary/Abstract Mutations in the ZEB2 transcription factor (TF) gene are the cause of Mowat-Wilson syndrome (MOWS), an intellectual and developmental disability (IDD). Whi...
Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program for Low-Income Young Adolescents
PROJECT SUMMARY Levels of adolescent anxiety, depression, and suicidality have been steadily rising over the last decade and have reached record levels in the wake of the COVID pan...
A randomized controlled trial of a preventive behavioral intervention for young adults with psychotic experiences
Project Summary Psychiatric illnesses affect millions of Americans and can be associated with substantial emotional and financial hardship for both those who are affected and their...
Impact of ATP-binding cassette A3 (ABCA3) mutations on alveolar type 2 cell function and genetic complementation
Summary/Abstract Pulmonary surfactant is comprised of phospholipids and protein components and helps prevent lung collapse by lowering surface tension in alveolar lining fluid. ATP...