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99,167 grants found
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Modeling Causal Effects of Components of Bundled Interventions with Application to a Multilevel Dental Caries Clinical Trial
This proposal seeks to develop new statistical methods applicable to studies of bundled interventions. Randomized clinical trials, including in dental research, often focus on mult...
Point-of-Care Brain Magnetic Resonance Imaging in Children with Head Trauma (BRAINCHILD)
PROJECT SUMMARY/ABSTRACT Traumatic brain injury (TBI) is a predominant cause of disability and death among children, leading to over 800,000 emergency department (ED) visits and 6,...
mHealth Intervention to Increase Uptake of Contraception and PrEP Among Female University Students in Zambia
Project Summary/Abstract HIV infection and unintended pregnancy are highly prevalent, life-altering events among adolescent girls and young women in low- and middle-income countrie...
Development of N-acyl fluspirilene mediated proteasome enhancement for the treatment of neurodegenerative diseases
Abstract. Currently there are limited therapeutic treatments to slow, prevent, or cure neurodegenerative diseases such as Alzheimer’s Disease or Alzheimer’s-related Dementias. Inst...
Tracking the Development and Influence of Post-Stroke Sensory Reweighting on Walking and Balance Outcomes
PROJECT SUMMARY Walking and balance impairment resulting from stroke significantly reduces functional walking independence, increases fall risk, and is a rising public health issue...
Circulating factors as a mechanism of improvements in vascular endothelial function with inorganic nitrate in patients with chronic kidney disease
PROJECT SUMMARY Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Vascular endothelial dysfunction is a key antecedent to CV...
Ribozyme-mediated killing of cells harboring cancer driver mutations
Project Summary: The strategy of selective killing cancer cells while sparing healthy cells holds great promise for cancer therapy, but its effective implementation remains a formi...
Measuring Brain Health Using Low-Field Portable MRI
PROJECT SUMMARY/ABSTRACT White matter hyperintensity (WMH) seen on MRI of the brain is an important biomarker of elevated risk for stroke and Alzheimer's disease and related d...
Evaluation of Uterine Fibroids by Contrast Enhanced Ultrasound (CEUS) and Subharmonic-Aided Pressure Estimation (SHAPE) Pre and Post Uterine Artery Embolization (UAE)
Uterine fibroids affect approximately 30% of all women in the United States or about 45 million individuals. The clinical diagnosis of uterine fibroids is two to three times more c...
Regulation of Muscle Stem Cells by Netrin Signaling
Skeletal muscle regenerates following injury, with muscle stem cells (MuSCs) the source of new myofibers. MuSCs are quiescent during homeostasis. Quiescence is an actively maintain...
Proteomic markers of risk for cognitive impairment in people with type 2 diabetes
PROJECT SUMMARY/ABSTRACT Type 2 diabetes increases a person’s risk for cognitive impairment syndromes including, cognitive decline, mild cognitive impairment, and Alzheimer’s Disea...
Improving Efficiency, Quality, and Equity: Randomized Controlled Evaluations of Remote vs. In-Person Clinical Trial Methods
PROJECT SUMMARY/ABSTRACT Remote trials (aka “virtual trials” or “decentralized trials”), in which patients receive treatment and provide study data without the need to travel to a...
Triangulating outcome assessments for blepharospasm
The dystonias overall are a rare neurologic disorder. Blepharospasm (BSP), is one of the most common forms of dystonia. BSP is characterized by involuntary abnormal facial expressi...
An AI-Directed CDS Tool to Reduce Iron Deficiency Anemia in Pregnancy: A Randomized Controlled Trial (AID-IDA Trial)
Project Summary Postpartum hemorrhage (PPH) is the most common complication during childbirth, occurring after 10% of all deliveries, and is a significant contributor to maternal m...
Directly targeting renal fibrosis in the aged with CKD using in vivo CAR-T cell therapy
Abstract: The hallmarks of chronic kidney disease (CKD) include fibrosis, increased inflammatory responses, and dysregulated mineral metabolism, which are all especially problemati...
A Comprehensive De Novo Variant Callset for the Gabriella Miller Kids First Pediatric Research Program Birth Defect Data
Project Summary/Abstract Birth defects occur in 1 in 33 individuals and result in yearly healthcare costs in the United States of America of >$23 billion. Understanding genetic...
Investigating the interplay between polymorphic α-syn fibril conformation and cell-dependent pathology
Project Summary Conformational variations in α-syn fibrils are proposed to be implicated in the emergence of distinct diseases within synucleinopathies, including Lewy body dementi...
Gut Microbiome Profiles in Association with Breast Cancer Recurrence and Mortality
PROJECT SUMMARY While breast cancer prognosis has substantially improved over the last three decades, recurrence remains a significant risk, particularly for African American patie...
RXR/PPARg heterodimer agonists for treating virus-induced acute lung injury
Project SummaryMacrophages (MΦ) respond to pathogens, tissue damage, and host-derived mediators by differentiating into distinct functional phenotypes that mediate host innate immu...
Astrocyte energy metabolism in opiate use disorders
Although the importance of astrocyte energy metabolism in supporting synaptic neurotransmission and synaptic plasticity has been demonstrated, there is no data for the contribution...