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99,167 grants found
Showing 4,041 – 4,060 of 99,167 grants
A Contrast-free Ultrasound-based Quantitative Angio Flow Imaging Technique to Assess Peripheral Arterial Disease of Lower Limb
Abstract/Summary PAD is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Up to now, assessment of PAD is mainly perform...
Harnessing Tumor and Circulating-Free DNA Methylation for Prognosis and Treatment Stratification in Adenoid Cystic Carcinoma
Abstract Adenoid Cystic Carcinoma (ACC) is a common salivary gland cancer for which there is no standard systemic therapy. ACC has a heterogeneous behavior; while most patients hav...
Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in Macrophages
ABSTRACT Tuberculosis continues to kill about 1 million people including children each year with 8 million new cases. Regrettably, coinfection with HIV-1 has aggravated the problem...
Pilot testing of metacognitive strategy training to address cancer-related cognitive impairment in breast cancer
Project Summary/Abstract The long-term goal of this research is to reduce the functional impact of cognitive impairment and improve quality-of-life in women treated for breast canc...
Structural basis of ER-mitochondria membrane contacts and neuronal health
Project Summary/Abstract The long-term objective of this research program is to understand the molecular mechanisms of Ca2+ signaling in neurons intimately linked to neural health...
Defining rates of cognitive aging in adults with and without dementia using the CODA cohort
PROJECT ABSTRACT Objective: The purpose of this application is to identify a rate of normative cognitive aging (i.e., cognitive aging in individuals without a neurocognitive disord...
Novel chemokine in the regulation of breast cancer metastasis
Project Summary Our long-term goal is to understand the immunobiology of cancer and identify the molecular drivers that promote the metastatic progression of cancer. We discovered...
Personalized Quality of Life Measurement
PROJECT SUMMARY/ABSTRACT. A lack of outcome-focused quality measures is holding back mental health (MH) progress. This gap means that regulatory bodies and third-party payers do no...
IND-enabling studies of non-immunogenic gene therapy for ultra-rare DMD patients excluded from dystrophin trials
Duchenne muscular dystrophy (DMD) is a rare childhood onset neuromuscular disease caused by genetic deficiency of the protein dystrophin.DMD is an incurable disease with a devastat...
The dual roles of GABA in excitatory synaptic plasticity
Project Summary In the brain, neurons are connected by intermingled excitatory (E) and inhibitory (I) synapses. The correct E/I balance is essential for proper brain function. Rece...
Neuroethics and human-centered design in neurotechnology
PROJECT SUMMARY/ABSTRACT Empirical neuroethics studies of patient/user perspectives have demonstrated profound effects that novel neurotechnological therapies, such as implanted de...
Feasibility/Acceptability of a Brief Motivational Intervention Integrating Online Personalized Feedback & Tailored Text Messages for Frequent/High-Intensity Cannabis Use in Post-Legalization Landscape
ABSTRACT Cannabis is a widely used psychoactive substance among young adults (YAs), with ~44% using in the past year. Daily use by YAs not attending college (14.5%) is 3x the preva...
In vivo Screening Methods Targeting Levels of Tau Protein within Mouse Brains
PROJECT SUMMARY/ABSTRACT Neurodegenerative diseases are devastating, fatal diseases that affect millions of people worldwide and have no definitive treatment. A well-known neurodeg...
Hyperpolarized MRI for Metabolic Imaging of Epileptic Tissue
Abstract Thirty percent of epilepsy patients have seizures despite best medical therapy. Continued seizures and polypharmacy are associated with poor quality of life. While epileps...
The Latino Youth and Family Empowerment Study – III (LYFE-III): Bringing to Scale a Culturally-Adapted and Evidence-Based Intervention for Latino Families
The Latino Youth and Family Empowerment Study – III (LYFE-III): Bringing to Scale a Culturally- Adapted and Evidence-Based Intervention for Latino Families Project Summary/Abstract...
ML-ROVER: Machine Learning to Reduce Laboratory Test Overutilization
More than 20% of laboratory tests in the intensive care unit are medically unnecessary. Laboratory overutilization contributes to reduced care quality and adverse complications inc...
Clinical Trial Readiness for Posterior Cortical Atrophy Syndrome
Abstract The overall goal of this project is to address the critical unmet need for longitudinal data from clinical outcome assessments (COAs) and plasma biomarkers for the rare sy...
Super-resolution chemical imaging via a diffusion-based deep generative model
Project Summary/Abstract The overarching objective of this project is to develop an advanced computational super-resolution model to enhance the throughput and resolution of chemic...
The promise of machine learning for novel approaches to archived developmental data
ABSTRACT. The availability of large data sets from research studies via data depositories is believed to be critical to tackle key questions about “complex diseases” like psychiatr...
Studying axo-glial interface in aging
“Studyingaxo-glial interface in aging” Peripheral neuropathies can result from inherited mutations, traumatic events, toxin exposures or be idiopathic, and are commonly affecting m...